7-chloro-9-phenyl-2-[(1R)-1-phenylethyl]-2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-one | 1203506-58-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-chloro-9-phenyl-2-[(1R)-1-phenylethyl]-2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-one
• 英文别名: 7-chloro-9-phenyl-2-[(1R)-1-phenylethyl]-3H-pyrrolo[3,4-b]quinolin-1-one
• CAS: 1203506-58-4
• 化学式: C₂₅H₁₉ClN₂O
• 分子量: 398.892
• InChiKey: LLIVROPOZGWZAK-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  以 乙腈 为溶剂， 反应 12.0h， 生成 7-chloro-9-phenyl-2-[(1R)-1-phenylethyl]-2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-one
  参考文献：
  名称：

  Diversity-Oriented Synthesis of Quinolines via Friedländer Annulation Reaction under Mild Catalytic Conditions

  摘要：

  An efficient and practical method has been manifested for the diversity-oriented synthesis of quinolines via Friedlander annulation reaction for the generation of a wide range of structurally interesting and pharmacologically significant compounds by using ceric ammonium nitrate as a catalyst (10 mol %) at ambient temperature in 45 min. A variety of functional groups are introduced at various positions of the quinoline moiety, and further the diversity of the core skeleton was expanded at R-1 and R-2 positions by the synthesis of various hybrids. Initial screening of the compounds for cytotoxicity against a series of cancer cell lines showed promising results,

  DOI：

  10.1021/cc900129t