8-Amino-2'-deoxyinosine | 364337-82-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 8-Amino-2'-deoxyinosine
• 英文别名: 8-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
• CAS: 364337-82-6
• 化学式: C₁₀H₁₃N₅O₄
• 分子量: 267.24
• InChiKey: YRWQBLJQYFNKRW-KVQBGUIXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  135
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  8-amino-2'-deoxyadenosine 、 腺苷 、 以 Sodium phosphate, tribasic- 为溶剂， 反应 72.0h， 生成 8-Amino-2'-deoxyinosine
  参考文献：
  名称：

  Compositions and methods of synthesis and use of novel nucleic acid structures

  摘要：

  本发明涉及一种通过用甲胺或二甲胺的水溶液处理8-偶氮基-2'-脱氧腺苷来制备8-氨基-2'-脱氧腺苷的方法。

  公开号：

  US20030135040A1

文献信息

• Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds
  申请人：——

  公开号：US20040034246A1

  公开（公告）日：2004-02-19

  Radiolabeled fluorinated compounds useful for imaging in the diagnosis of Parkinson's Disease are disclosed. Methods and kits for their synthesis are also disclosed.

  本发明公开了用于帕金森病诊断成像的放射性标记氟化合物。同时，还公开了其合成的方法和试剂盒。
• Parallel stranded duplexes of deoxyribonucleic acid and methods of use
  申请人：——

  公开号：US20040029160A1

  公开（公告）日：2004-02-12

  A triplex comprising a hairpin having at least one polypyrimidine sequence linked to a complementary polypurine wherein the polypurine sequence is at least one 8-aminopurine such as 8-aminoadenine, 8-aminoguanine and 8-aminohypoxanthine, and at least one polypyrimidine target sequence that is complementary and antiparallel to the polypurine sequence. The polypurine sequence binds the polypyrimidine target sequence by forming a triplex helix. Methods for preparing the hairpins and for stabilizing the triplex are provided. Methods for targeting single-stranded oligonucleotides and DNA is described using the hairpins and triplexes of this invention.

  一种由发夹组成的三螺旋体，发夹具有至少一个与互补多嘌呤连接的多嘧啶序列，其中多嘌呤序列是至少一个 8-氨基嘌呤，如 8-氨基腺嘌呤、8-氨基鸟嘌呤和 8-氨基次黄嘌呤，以及至少一个与多嘌呤序列互补和反平行的多嘧啶目标序列。多嘌呤序列通过形成三重螺旋与多嘧啶靶序列结合。提供了制备发夹和稳定三重螺旋的方法。使用本发明的发夹和三重螺旋，描述了靶向单链寡核苷酸和 DNA 的方法。
• Triplex-forming oligonucleotides containing modified purines and their applications
  申请人：Eritja Ramon

  公开号：US20050014164A1

  公开（公告）日：2005-01-20

  This invention presents oligonucleotide derivatives comprising a complementary purine part carrying one or more 8-aminopurines such as 8-aminoadenine, 8-aminoguanine and 8-aminohypoxanthine connected with a linker to an oligonucleotide carrying either GT or GA sequences. These oligonucleotide derivatives bind polypyrimidine sequences complementary (in the antiparallel sense) to the purine part by formation of purine-purine-pyrimidine triple helices. The oligonucleotides carrying 8-aminoguanines described in this invention have better binding properties than unmodified oligonucleotides. This enhancement in stability, coupled with the lack of an acidic pH requirement, makes the oligonucleotides carrying 8-aminopurines effective in applications involving oligonucleotide targeting of single stranded RNA in vitro and in vivo, as well as applications requiring triple helix formation.

  本发明提出了寡核苷酸衍生物，其包含的互补嘌呤部分带有一个或多个 8-氨基嘌呤，如 8-氨基腺嘌呤、8-氨基鸟嘌呤和 8-氨基次黄嘌呤，并与带有 GT 或 GA 序列的寡核苷酸连接。这些寡核苷酸衍生物通过形成嘌呤-嘌呤-嘧啶三螺旋，与嘌呤部分互补（反平行）的多嘧啶序列结合。与未修饰的寡核苷酸相比，本发明所述的含有 8-氨基鸟嘌呤的寡核苷酸具有更好的结合性能。这种稳定性的提高，再加上不需要酸性 pH 值，使得携带 8-氨基嘌呤的寡核苷酸在涉及体外和体内单链 RNA 的寡核苷酸靶向应用以及需要形成三螺旋的应用中非常有效。
• COMPOSITIONS AND METHODS OF SYNTHESIS AND USE OF NOVEL NUCLEIC ACID STRUCTURES
  申请人：Cygene, Inc.

  公开号：EP1228243A1

  公开（公告）日：2002-08-07
• EP1228243A4
  申请人：——

  公开号：EP1228243A4

  公开（公告）日：2005-07-20