D-glucose monohydrate | 136831-99-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-glucose monohydrate
• 英文别名: beta-D-Glucopyranose, monohydrate；(2R,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol;hydrate
• CAS: 136831-99-7
• 化学式: C₆H₁₂O₆*H₂O
• 分子量: 198.173
• InChiKey: OSNSWKAZFASRNG-WYRLRVFGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.05
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  111
• 氢给体数：
  6
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  sodium hydroxide 、 Aluminum(III) chloride hexahydrate 、 D-glucose monohydrate 在 sodium chloride 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Glucose and glucuronic acid interactions with hydrolysed aluminium(III)

  摘要：

  Interaction of D-glucose and b-glucuronic acid and of hydrolysed aluminium (III) has been studied in 0.6 M NaCl solution, Isolated solids were analysed and studied by means of IR and C-13 NMR spectroscopy. Soluble samples close to the precipitation boundary were examined with UV spectroscopy. Glucuronic acid showed higher affinity toward binding to the aluminium hydroxide matrix than glucose, It is concluded that glucose is bound via hydroxyl groups on C(4) and C(6) atoms in alpha- and beta-pyranose forms. Glucuronic acid is bound in alpha- and beta-pyranose forms via the carboxyl group and the hydroxyl group on the C(4) atom.

  DOI：

  10.1016/0277-5387(94)00341-b

文献信息

• Compositions and methods related to structures that cross the blood brain barrier
  申请人：The Regents of the University of California

  公开号：US10906981B2

  公开（公告）日：2021-02-02

  Provided herein are compositions, kits, methods and systems related to administering a structure that crosses the blood brain barrier (BBB) along with a monosaccharide, either simultaneously or consecutively. The structure may be, for example an antibody or fusion antibody that binds to an insulin receptor.

  本文提供的组合物、试剂盒、方法和系统与同时或连续给药可穿过血脑屏障（BBB）的结构和单糖有关。例如，该结构可以是与胰岛素受体结合的抗体或融合抗体。
• COMPOSITIONS AND METHODS FOR TREATMENT OF MITOCHONDRIAL RESPIRATORY CHAIN DYSFUNCTION AND OTHER MITOCHONDRIAL DISORDERS
  申请人：The Children's Hospital Of Philadelphia

  公开号：EP3813837A1

  公开（公告）日：2021-05-05
• COMPOSITIONS AND METHODS RELATED TO STRUCTURES THAT CROSS THE BLOOD BRAIN BARRIER
  申请人：The Regents of the University of California

  公开号：US20160152719A1

  公开（公告）日：2016-06-02

  Provided herein are compositions, kits, methods and systems related to administering a structure that crosses the blood brain barrier (BBB) along with a monosaccharide, either simultaneously or consecutively. The structure may be, for example an antibody or fusion antibody that binds to an insulin receptor.
• [EN] A CRYSTALLINE HETEROAROMATIC FLUOROGLYCOSIDE HYDRATE, PROCESSES FOR MAKING, METHODS OF USE AND PHARMACEUTICAL COMPOSITIONS THEREOF<br/>[FR] HYDRATE DE FLUOROGLYCOSIDE HÉTÉROAROMATIQUE CRISTALLIN, SES PROCÉDÉS DE FABRICATION, SES PROCÉDÉS D'UTILISATION ET COMPOSITIONS PHARMACEUTIQUES LE CONTENANT
  申请人：SANOFI AVENTIS

  公开号：WO2010068601A1

  公开（公告）日：2010-06-17

  A novel crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof. The invention relates to a crystalline hydrate of the formula (I) in which n has a value of from 0.9 to 1.1. The compound is suitable, for example, as an antidiabetic.
• [EN] COMPOSITIONS AND METHODS RELATED TO STRUCTURES THAT CROSS THE BLOOD BRAIN BARRIER<br/>[FR] COMPOSITIONS ET PROCÉDÉS ASSOCIÉS À DES STRUCTURES QUI TRAVERSENT LA BARRIÈRE HÉMATO-ENCÉPHALIQUE
  申请人：ARMAGEN TECHNOLOGIES INC

  公开号：WO2015009961A1

  公开（公告）日：2015-01-22

  Provided herein are compositions, kits, methods and systems related to administering a structure that crosses the blood brain barrier (BBB) along with a monosaccharide, either simultaneously or consecutively. The structure may be, for example an antibody or fusion antibody that binds to an insulin receptor.