4-[Benzyl(methyl)amino]-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(furan-2-yl)-1-phenylbutan-2-ol | 861709-21-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-[Benzyl(methyl)amino]-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(furan-2-yl)-1-phenylbutan-2-ol
• CAS: 861709-21-9
• 化学式: C₃₂H₃₁BrN₂O₃
• 分子量: 571.514
• InChiKey: RKJGXJLDESPDFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  38
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  58.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-[Benzyl(methyl)amino]-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(furan-2-yl)-1-phenylbutan-2-ol 在 palladium 10% on activated carbon 甲酸铵 作用下， 以 甲醇 为溶剂， 反应 1.0h， 生成 2-(Furan-2-yl)-1-(2-methoxyquinolin-3-yl)-4-(methylamino)-1-phenylbutan-2-ol
  参考文献：
  名称：

  [EN] QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS
  [FR] DERIVES DE QUINOLEINE UTILISES COMME AGENTS ANTIBACTERIENS

  摘要：

  公开号：

  WO2007014934A3

文献信息

• Novel mycobacterial inhibitors
  申请人：Guillemont Emile, Georges Jerome

  公开号：US20070082895A1

  公开（公告）日：2007-04-12

  The present invention relates to novel substituted quinoline derivatives according to the general formula (Ia) or the general formula (Ib) salts, quaternary amines, stereochemically isomeric forms, tautomeric forms and N-oxide forms thereof, wherein R 1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R 2 is hydrogen, hydroxy, thio, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula R 3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; R 4 is hydrogen, alkyl or benzyl; R 5 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R 5 radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl; r is 1, 2, 3, 4 or 5; R 6 is hydrogen, alkyl, Ar or Het; R 7 is hydrogen or alkyl; R 8 is oxo; or R 7 and R 8 taken together form the radical CH═CH—N═; Z is CH 2 or C(═O). The claimed compounds are useful for the treatment of mycobacterial diseases, particularly those diseases caused by pathogenic mycobacteria such as M. tuberculosis, M. bovis, M. avium, M. smegmatis and M. marinum. Also claimed is a pharmaceutical composition containing a compound of the present invention, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of mycobacterial diseases and a process for preparing the claimed compounds.
• Quinoline Derivatives as Antibacterial Agents
  申请人：Andries Koenraad Jozef Lodewijk Marcel

  公开号：US20080227775A1

  公开（公告）日：2008-09-18

  Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of Formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a quaternary amine thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R 1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R 2 is hydrogen, hydroxy, thio, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula R 3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; R 4 is hydrogen, alkyl or benzyl; R 5 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R 5 radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl; r is 1, 2, 3, 4 or 5; R 6 is hydrogen, alkyl, Ar or Het; R 7 is hydrogen or alkyl; R 5 is oxo; or R 7 and R 5 together form the radical —CH═CH—N═; Z is CH 2 or C(═O).
• US7338949B2
  申请人：——

  公开号：US7338949B2

  公开（公告）日：2008-03-04
• US8691800B2
  申请人：——

  公开号：US8691800B2

  公开（公告）日：2014-04-08