ethyl 3-(4-tert-butylphenyl)-1-{[5-hydroxy-4'-(methoxycarbonyl)biphenyl-3-yl]methyl}-1H-indole-2-carboxylate | 1010413-04-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: ethyl 3-(4-tert-butylphenyl)-1-{[5-hydroxy-4'-(methoxycarbonyl)biphenyl-3-yl]methyl}-1H-indole-2-carboxylate
• 英文别名: ethyl 3-(4-tert-butylphenyl)-1-[[3-hydroxy-5-(4-methoxycarbonylphenyl)phenyl]methyl]indole-2-carboxylate
• CAS: 1010413-04-3
• 化学式: C₃₆H₃₅NO₅
• 分子量: 561.678
• InChiKey: KLBYNUDIUSENKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  42
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  77.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 3-(4-tert-butylphenyl)-1-{[5-hydroxy-4'-(methoxycarbonyl)biphenyl-3-yl]methyl}-1H-indole-2-carboxylate 、 碘甲烷 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  WO2008/28118

  摘要：

  公开号：
• 作为产物：
  描述：

  在 palladium 10% on activated carbon 氢气 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 0.33h， 以79%的产率得到ethyl 3-(4-tert-butylphenyl)-1-{[5-hydroxy-4'-(methoxycarbonyl)biphenyl-3-yl]methyl}-1H-indole-2-carboxylate
  参考文献：
  名称：

  WO2008/28118

  摘要：

  公开号：

文献信息

• 1H-Indole-2-Carboxylic Acid Derivatives Useful As PPAR Modulators
  申请人：Oplinger Jeffrey Alan

  公开号：US20100240642A1

  公开（公告）日：2010-09-23

  The present invention relates to certain indole derivatives that are modulators of PPARγ, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine.

  本发明涉及某些吲哚衍生物，它们是PPARγ的调节剂，涉及它们的制备过程，包含它们的制药组合物以及它们在医学上的用途。
• 1H-INDOLE-2-CARBOXYLIC ACID DERIVATIVES USEFUL AS PPAR MODULATORS
  申请人：SmithKline Beecham Corporation

  公开号：EP2081894A1

  公开（公告）日：2009-07-29
• CROSSLINKED COMPOSITION COMPRISING A CORE/SHELL COPOLYMER, METHOD OF OBTAINING SAME AND USES THEREOF
  申请人：Gervat Laurent

  公开号：US20090306246A1

  公开（公告）日：2009-12-10

  The invention relates to is a crosslinked composition containing in parts by weight: 20 to 100 parts of at least one elastomer (I), 2 to 50 parts of at least one core/shell copolymer (II), and 0 to 100 parts of at least one thermoplastic polymer (III). The invention also relates to a method of producing one such crosslinked composition, which is characterized in that it consists in: mixing an elastomer and a core/shell copolymer optionally in the presence of: a grafted polyolefin, a plasticizer, fillers and/or additives, and a suitably-selected crosslinking system, and subsequently crosslinking said mixture at a suitable temperature. In a preferred embodiment of the invention, the mixture is crosslinked at a temperature of between 150 and 320° C. The invention method be carried out in an internal mixer, or, alternately, in a twin-screw extruder or a Buss®-type co-kneader. Depending on the case, the resulting mass is calendared or extruded, cooled and subsequently granulated. The granules thus obtained are then ready to be transformed, by means of heating, into sheets, plates, extrusions, tubes or other desired products. The invention further relates to the use of one such composition in the production of ducts, pipes, tubing, couplers or similar for conveying fluids, such as the fluid transfer conduits, pipes and other elements which are used in the automobile industry in braking, cooling, steering and air-conditioning systems. The inventive crosslinked composition can also be used in the production of belts, tires, electrical cable sheaths, and shoe soles.”
• US6028142A
  申请人：——

  公开号：US6028142A

  公开（公告）日：2000-02-22
• [EN] 1H-INDOLE-2-CARBOXYLIC ACID DERIVATIVES USEFUL AS PPAR MODULATORS<br/>[FR] COMPOSÉS CHIMIQUES
  申请人：SMITHKLINE BEECHAM CORPORAITON

  公开号：WO2008028118A1

  公开（公告）日：2008-03-06

  [EN] The present invention relates to certain indole derivatives that are modulators of PPAR, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine.
  [FR] La présente invention concerne certains dérivés d'indole qui sont des modulateurs de PPAR, leurs procédés de préparation, des compositions pharmaceutiques les contenant et leur utilisation en médecine.