2-azido-1-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-ethanone | 1094609-91-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-azido-1-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-ethanone
• 英文别名: 1-(1-azatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraen-3-yl)-2-azidoethanone
• CAS: 1094609-91-2
• 化学式: C₁₃H₁₂N₄O
• 分子量: 240.264
• InChiKey: QBQDVKBNARHEBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  36.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-azido-1-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-ethanone 、 二碳酸二叔丁酯 在 palladium 10% on activated carbon 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 以46%的产率得到[2-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  WO2009/2806

  摘要：

  公开号：
• 作为产物：
  描述：

  2-chloro-1-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-ethanone 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以90%的产率得到2-azido-1-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-ethanone
  参考文献：
  名称：

  WO2009/2806

  摘要：

  公开号：

文献信息

• Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
  申请人：ArQule, Inc.

  公开号：US08304425B2

  公开（公告）日：2012-11-06

  The present invention relates to pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosucciniroide compounds of formulae (I)-(IV), and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosuccinimide compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound of pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosuccinimide compound of the present invention.

  本发明涉及式(I)-(IV)的吡咯烷-2-酮、吡咯烷-2,5-二酮、吡咯烷和硫代琥珀酰亚胺化合物以及这些化合物的制备方法。本发明还涉及包含吡咯烷-2-酮、吡咯烷-2,5-二酮、吡咯烷和硫代琥珀酰亚胺化合物的药物组合物。本发明提供了通过向需要治疗细胞增殖性疾病（如癌症）的受试者投与本发明的吡咯烷-2-酮、吡咯烷-2,5-二酮、吡咯烷和硫代琥珀酰亚胺化合物的治疗有效量的方法。
• Pyrrolidinone, Pyrrolidine-2, 5-Dione, Pyrrolidine and Thiosuccinimide Derivatives, Compositions and Methods for Treatment of Cancer
  申请人：Wang Jianqiang

  公开号：US20100178291A1

  公开（公告）日：2010-07-15

  The present invention relates to pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosucciniroide compounds of formulae (I)-(IV), and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosuccinimide compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound of pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosuccinimide compound of the present invention.

  本发明涉及式(I)-(IV)的吡咯烷-2-酮、吡咯烷-2,5-二酮、吡咯烷和硫代琥珀酰亚胺化合物，以及这些化合物的制备方法。本发明还涉及包括吡咯烷-2-酮、吡咯烷-2,5-二酮、吡咯烷和硫代琥珀酰亚胺化合物的药物组合物。本发明提供了一种通过向需要治疗细胞增殖性疾病（如癌症）的受试者施用本发明的吡咯烷-2-酮、吡咯烷-2,5-二酮、吡咯烷和硫代琥珀酰亚胺化合物的治疗有效量来治疗该疾病的方法。
• PYRROLIDINONE, PYRROLIDINE-2, 5-DIONE, PYRROLIDINE AND THIOSUCCINIMIDE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER
  申请人：ArQule, Inc.

  公开号：EP2170870A1

  公开（公告）日：2010-04-07
• US8304425B2
  申请人：——

  公开号：US8304425B2

  公开（公告）日：2012-11-06
• [EN] PYRROLIDINONE, PYRROLIDINE-2, 5-DIONE, PYRROLIDINE AND THIOSUCCINIMIDE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER<br/>[FR] DÉRIVÉS DE PYRROLIDINONE, PYRROLIDINE-2,5-DIONE, PYRROLIDINE ET THIOSUCCINIMIDE, COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT D'UN CANCER
  申请人：ARQULE INC

  公开号：WO2009002806A1

  公开（公告）日：2008-12-31

  [EN] The present invention relates to pyrrolidin-2-one, pyrrolidin-2, 5-dione, pyrrolidine and thiosucciniroide compounds of formulae (I) - (IV), and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidin-2-one, pyrrolidin-2, 5-dione, pyrrolidine and thiosuccinimide compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound of pyrrolidin-2-one, pyrrolidin-2, 5-dione, pyrrolidine and thiosuccinimide compound of the present invention.
  [FR] La présente invention concerne des composés de pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine et thiosuccinimide représentés par les formules I) - (IV), et des procédés de préparation de ces composés. La présente invention concerne également des compositions pharmaceutiques contenant les composés de pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine et thiosuccinimide. La présente invention concerne des procédés de traitement d'un trouble de prolifération cellulaire, tel qu'un cancer, par l'administration à un patient la nécessitant d'une quantité thérapeutiquement efficace d'un composé de pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine et thiosuccinimide de la présente invention.