3-[(4-Fluorophenyl)methyl]quinolin-8-ol | 457948-42-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-[(4-Fluorophenyl)methyl]quinolin-8-ol
• CAS: 457948-42-4
• 化学式: C₁₆H₁₂FNO
• 分子量: 253.276
• InChiKey: WITPYXGAWFTXOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-[(4-Fluorophenyl)methyl]quinolin-8-ol 在 N-溴代丁二酰亚胺(NBS) 、 二异丙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以42.5%的产率得到7-Bromo-3-[(4-fluorophenyl)methyl]quinolin-8-ol
  参考文献：
  名称：

  NITROGEN-CONTAINING HETEROARYL COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY

  摘要：

  公开号：

  EP1375486B1
• 作为产物：
  描述：

  3-[(4-Fluorophenyl)methyl]-8-methoxyquinoline 在 吡啶盐酸盐 作用下， 反应 14.5h， 以90.5%的产率得到3-[(4-Fluorophenyl)methyl]quinolin-8-ol
  参考文献：
  名称：

  NITROGEN-CONTAINING HETEROARYL COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY

  摘要：

  公开号：

  EP1375486B1

文献信息

• New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof
  申请人：POLICHEM S.A.

  公开号：EP2345643A1

  公开（公告）日：2011-07-20

  New tertiary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof are disclosed. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis. These compounds are also active against Candida species such as Candida Albicans and Candida Glabrata.

  新的三级8-羟基喹啉-7-甲酰胺衍生物的一般化学式（I）及其药用盐已被披露。 这些化合物可用作抗真菌剂。具体来说，这些化合物已对白色念珠菌、白色念珠菌、黑曲霉和短柄曲霉进行了测试。这些化合物也对白色念珠菌属的物种如白色念珠菌和光滑白色念珠菌具有活性。
• [EN] NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF<br/>[FR] NOUVEAUX DÉRIVÉS DE 8-HYDROXYQUINOLINE-7-CARBOXAMIDE TERTIAIRES ET LEURS UTILISATIONS
  申请人：POLICHEM SA

  公开号：WO2011080264A1

  公开（公告）日：2011-07-07

  New tertiary 8-hydroxyquinoiine-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof are disclosed. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis. These compounds are also active against Candida species such as Candida Albicans and Candida Glabrata.

  新的三级8-羟基喹啉-7-甲酰胺衍生物的一般式（I）及其药用盐已被披露。这些化合物可用作抗真菌剂。具体来说，这些化合物已对白色念珠菌、小耳癣菌、黑曲霉和短柄镰刀菌进行了测试。这些化合物也对白色念珠菌属如白色念珠菌和光滑白色念珠菌具有活性。
• [EN] NEW SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES.<br/>[FR] NOUVEAUX DÉRIVÉS DE 8-HYDROXYQUINOLINE-7-CARBOXAMIDE SECONDAIRES
  申请人：POLICHEM SA

  公开号：WO2011080266A1

  公开（公告）日：2011-07-07

  The present invention provides new secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopuiariopsis Brevicaulis. Many of these compounds are active against Candida species such as Candida Albicans and Candida Glabrata.

  本发明提供了一种新的通式（I）的次级8-羟基喹啉-7-羧酰胺衍生物及其药物可接受的盐。这些化合物可用作抗真菌剂。具体而言，这些化合物已经对红色毛癣菌、鼠癣菌、黑曲霉和短柄镰刀菌进行了测试。这些化合物中的许多对白色念珠菌如白色念珠菌和光滑念珠菌等具有活性。
• New secondary 8-hydroxyquinoline-7-carboxamide derivatives
  申请人：POLICHEM S.A.

  公开号：EP2345641A1

  公开（公告）日：2011-07-20

  The present invention provides new secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis. Many of these compounds are active against Candida species such as Candida Albicans and Candida Glabrata,

  本发明提供了一种新的通式（I）的次级8-羟基喹啉-7-甲酰胺衍生物及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体地，这些化合物已经对Tricophyton Rubrum，Tricophyton Mentagrophytes，Aspergillus Niger和Scopulariopsis Brevicaulis进行了测试。其中许多化合物对白色念珠菌属（如白色念珠菌和光滑白色念珠菌）具有活性。
• SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES
  申请人：Gagliardi Stefania

  公开号：US20120316167A1

  公开（公告）日：2012-12-13

  The present invention provides new secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis . Many of these compounds are active against Candida species such as Candida Albicans and Candida Glabrata .

  本发明提供了新的通式（I）的二次8-羟基喹啉-7-羧酰胺衍生物及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体地，这些化合物已经对Tricophyton Rubrum，Tricophyton Mentagrophytes，Aspergillus Niger和Scopulariopsis Brevicaulis进行了测试。其中许多化合物对Candida Albicans和Candida Glabrata等Candida物种具有活性。