1-{3-[4-morpholin-4-yl-6-(4-trifluoromethoxy-phenylamino)-pyrimidin-2-yl]-phenyl}-ethanone | 881194-16-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-{3-[4-morpholin-4-yl-6-(4-trifluoromethoxy-phenylamino)-pyrimidin-2-yl]-phenyl}-ethanone
• 英文别名: 1-[3-[4-morpholin-4-yl-6-[4-(trifluoromethoxy)anilino]pyrimidin-2-yl]phenyl]ethanone
• CAS: 881194-16-7
• 化学式: C₂₃H₂₁F₃N₄O₃
• 分子量: 458.44
• InChiKey: ZWSPZXZPVNIPTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  76.6
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  1-{3-[4-chloro-6-(4-trifluoromethoxy-phenylamino)-pyrimidin-2-yl]-phenyl}-ethanone 、 吗啉 在 氮气 、 crude compound 作用下， 以 正丁醇 为溶剂， 反应 24.0h， 以to afford the desired compound (0.11 g, 75%) as a white solid的产率得到1-{3-[4-morpholin-4-yl-6-(4-trifluoromethoxy-phenylamino)-pyrimidin-2-yl]-phenyl}-ethanone
  参考文献：
  名称：

  Novel pyrimidine compounds, process for their preparation and compositions containing them

  摘要：

  本发明提供了新的杂环化合物，特别是取代的嘧啶，制备和使用这些杂环化合物的方法和组合物，以及治疗各种疾病和疾病状态的方法，包括动脉粥样硬化、关节炎、再狭窄、糖尿病肾病或血脂异常，或由Perlecan低表达介导的疾病状态。

  公开号：

  US20060084645A1

文献信息

• Novel pyrimidine compounds, process for their preparation and compositions containing them
  申请人：Pal Manojit

  公开号：US20060084645A1

  公开（公告）日：2006-04-20

  The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

  本发明提供了新的杂环化合物，特别是取代的嘧啶，制备和使用这些杂环化合物的方法和组合物，以及治疗各种疾病和疾病状态的方法，包括动脉粥样硬化、关节炎、再狭窄、糖尿病肾病或血脂异常，或由Perlecan低表达介导的疾病状态。
• [EN] NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX COMPOSES DE PYRIMIDINE, LEUR PROCEDE DE PREPARATION, ET COMPOSITIONS LES CONTENANT
  申请人：REDDY US THERAPEUTICS INC

  公开号：WO2006034473A3

  公开（公告）日：2006-12-14
• NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM
  申请人：Reddy US Therapeutics, Inc.

  公开号：EP1796673A2

  公开（公告）日：2007-06-20
• US7820654B2
  申请人：——

  公开号：US7820654B2

  公开（公告）日：2010-10-26
• Pyrimidine compounds, process for their preparation and compositions containing them
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：US07820654B2

  公开（公告）日：2010-10-26

  The present invention is directed to a compounds, methods and compositions for making the compounds and methods of treating a variety of diseases and disease states including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan, comprising the administration of new heterocyclic compounds, particularly substituted pyrimidines. The present invention is directed to novel compounds represented by the general formula:

  本发明涉及一种化合物、制备该化合物的方法和组合物，以及治疗多种疾病和疾病状态的方法，包括动脉粥样硬化、关节炎、再狭窄、糖尿病肾病或血脂异常，或由Perlecan表达低下介导的疾病状态，包括给予新的杂环化合物，特别是取代嘧啶。本发明涉及由一般公式表示的新型化合物：