1-(2-amino-6-hydroxyphenyl)-2,2,2-trifluoroethanone | 1235775-19-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-amino-6-hydroxyphenyl)-2,2,2-trifluoroethanone
• 英文别名: 2'-Amino-6'-hydroxy-2,2,2-trifluoroacetophenone
• CAS: 1235775-19-5
• 化学式: C₈H₆F₃NO₂
• 分子量: 205.136
• InChiKey: VTTIGLVJEAOQKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-(2-amino-6-methoxyphenyl)-2,2,2-trifluoroethanone 在 氢溴酸 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 2.0h， 以80%的产率得到1-(2-amino-6-hydroxyphenyl)-2,2,2-trifluoroethanone
  参考文献：
  名称：

  An alternative route for synthesis of o-trifluoroacetylanilines as useful fluorine-containing intermediates

  摘要：

  A series of o-trifluoroacetyl aniline derivatives were synthesized in three steps. In this method, we first utilized trifluoroacetic anhydride to introduce trifluoroacetyl group to the ortho position of aniline with higher yield than that of some previously reported methods. In addition, the procedure is shown to be highly regiospecific. This type of compounds can be used as the key intermediates in the preparation of a variety of inhibitors of HIV reverse transcriptase which is an important pharmacological target of many anti-AIDS agents. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2010.04.002

文献信息

• An alternative route for synthesis of o-trifluoroacetylanilines as useful fluorine-containing intermediates
  作者：Lingjian Zhu、Zhenyuan Miao、Chunquan Sheng、Jianzhong Yao、Chunlin Zhuang、Wannian Zhang

  DOI：10.1016/j.jfluchem.2010.04.002

  日期：2010.7

  A series of o-trifluoroacetyl aniline derivatives were synthesized in three steps. In this method, we first utilized trifluoroacetic anhydride to introduce trifluoroacetyl group to the ortho position of aniline with higher yield than that of some previously reported methods. In addition, the procedure is shown to be highly regiospecific. This type of compounds can be used as the key intermediates in the preparation of a variety of inhibitors of HIV reverse transcriptase which is an important pharmacological target of many anti-AIDS agents. (C) 2010 Elsevier B.V. All rights reserved.