1-Benzyl-3-indol-1-yl-4-(2-methoxypyridin-3-yl)pyrrole-2,5-dione | 918898-24-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-Benzyl-3-indol-1-yl-4-(2-methoxypyridin-3-yl)pyrrole-2,5-dione
• 英文别名: 1-benzyl-3-indol-1-yl-4-(2-methoxypyridin-3-yl)pyrrole-2,5-dione
• CAS: 918898-24-5
• 化学式: C₂₅H₁₉N₃O₃
• 分子量: 409.444
• InChiKey: FHOIJXHTXFHKJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  64.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-Benzyl-3-indol-1-yl-4-(2-methoxypyridin-3-yl)pyrrole-2,5-dione 在 吡啶 、 四(三苯基膦)钯 、 叔丁基二甲基氯硅烷 、 三乙胺 、 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 28.0h， 生成 N-benzyl pyrido[3,2-e]-2,10b-diaza-cyclopenta[c]fluorene-1,3-dione
  参考文献：
  名称：

  Synthesis and cyclometalation of a pyrido[3,2-e]-2,10b-diaza-cyclopenta[c]fluorene-1,3-dione scaffold

  摘要：

  The synthesis of a pyrido[3,2-e]-2, 10b-diaza-cyclopenta[c]fluorene-1, 3-dione scaffold is disclosed, which was synthesized using a Suzuki cross-coupling reaction and an intramolecular Heck cyclization as the key steps. This heterocyclic system can serve as a bidentate ligand as demonstrated by the formation and structural analysis of a derived ruthenium complex. The new scaffold constitutes an interesting candidate for the development of organometallic protein kinase inhibitors. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.10.054
• 作为产物：
  描述：

  2-甲氧基吡啶基-3-硼酸 、 1-benzyl-3-bromo-4-(1H-indol-1-yl)-1H-pyrrole-2,5-dione 在 sodium carbonate 、 三苯基膦 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 7.0h， 以70%的产率得到1-Benzyl-3-indol-1-yl-4-(2-methoxypyridin-3-yl)pyrrole-2,5-dione
  参考文献：
  名称：

  Synthesis and cyclometalation of a pyrido[3,2-e]-2,10b-diaza-cyclopenta[c]fluorene-1,3-dione scaffold

  摘要：

  The synthesis of a pyrido[3,2-e]-2, 10b-diaza-cyclopenta[c]fluorene-1, 3-dione scaffold is disclosed, which was synthesized using a Suzuki cross-coupling reaction and an intramolecular Heck cyclization as the key steps. This heterocyclic system can serve as a bidentate ligand as demonstrated by the formation and structural analysis of a derived ruthenium complex. The new scaffold constitutes an interesting candidate for the development of organometallic protein kinase inhibitors. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.10.054

文献信息

• Synthesis and cyclometalation of a pyrido[3,2-e]-2,10b-diaza-cyclopenta[c]fluorene-1,3-dione scaffold
  作者：Seann P. Mulcahy、Patrick J. Carroll、Eric Meggers

  DOI：10.1016/j.tetlet.2006.10.054

  日期：2006.12

  The synthesis of a pyrido[3,2-e]-2, 10b-diaza-cyclopenta[c]fluorene-1, 3-dione scaffold is disclosed, which was synthesized using a Suzuki cross-coupling reaction and an intramolecular Heck cyclization as the key steps. This heterocyclic system can serve as a bidentate ligand as demonstrated by the formation and structural analysis of a derived ruthenium complex. The new scaffold constitutes an interesting candidate for the development of organometallic protein kinase inhibitors. (c) 2006 Elsevier Ltd. All rights reserved.