6-chloro-9-(methoxymethyl)-8-(3-methoxyphenyl)-2-(trimethylsilyl)-9H-purine | 1265221-91-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-chloro-9-(methoxymethyl)-8-(3-methoxyphenyl)-2-(trimethylsilyl)-9H-purine
• 英文别名: [6-Chloro-9-(methoxymethyl)-8-(3-methoxyphenyl)purin-2-yl]-trimethylsilane；[6-chloro-9-(methoxymethyl)-8-(3-methoxyphenyl)purin-2-yl]-trimethylsilane
• CAS: 1265221-91-7
• 化学式: C₁₇H₂₁ClN₄O₂Si
• 分子量: 376.918
• InChiKey: MEOCWMKTXLDCJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  62.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-chloro-9-(methoxymethyl)-8-(3-methoxyphenyl)-2-(trimethylsilyl)-9H-purine 在 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex 、 palladium on carbon 、 ammonium formate 、 zinc(II) chloride 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 1.5h， 生成 6-iodo-9-(methoxymethyl)-8-(3-methoxyphenyl)-2-(trimethylsilyl)-9H-purine
  参考文献：
  名称：

  Trifunctionalization of the Purine Scaffold Using Mg and Zn Organometallic Intermediates

  摘要：

  Starting from an appropriate 6-chloro-2-TMS-purine derivative, a regioselective functionalization of the purine scaffold was achieved successively at positions 8, 6, and 2 via zinc and magnesium intermediates which were generated either by a direct zincation with TMPZnCl.LiCl or by an l/Mg exchange with iPrMgCl.

  DOI：

  10.1021/ol103057k
• 作为产物：
  描述：

  6-氯-9-(甲氧基甲基)-9H-嘌呤 在 2,2,6,6-四甲基哌啶 、 正丁基锂 、 zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 18.58h， 生成 6-chloro-9-(methoxymethyl)-8-(3-methoxyphenyl)-2-(trimethylsilyl)-9H-purine
  参考文献：
  名称：

  Trifunctionalization of the Purine Scaffold Using Mg and Zn Organometallic Intermediates

  摘要：

  Starting from an appropriate 6-chloro-2-TMS-purine derivative, a regioselective functionalization of the purine scaffold was achieved successively at positions 8, 6, and 2 via zinc and magnesium intermediates which were generated either by a direct zincation with TMPZnCl.LiCl or by an l/Mg exchange with iPrMgCl.

  DOI：

  10.1021/ol103057k

文献信息

• Trifunctionalization of the Purine Scaffold Using Mg and Zn Organometallic Intermediates
  作者：Silvia Zimdars、Xavier Mollat du Jourdin、François Crestey、Thomas Carell、Paul Knochel

  DOI：10.1021/ol103057k

  日期：2011.2.18

  Starting from an appropriate 6-chloro-2-TMS-purine derivative, a regioselective functionalization of the purine scaffold was achieved successively at positions 8, 6, and 2 via zinc and magnesium intermediates which were generated either by a direct zincation with TMPZnCl.LiCl or by an l/Mg exchange with iPrMgCl.