(S)-5-Phenyl-3-(pyrrolidin-2-yl)-1,2,4-oxadiazole | 681239-98-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (S)-5-Phenyl-3-(pyrrolidin-2-yl)-1,2,4-oxadiazole
• 英文别名: 5-phenyl-3-[(2S)-pyrrolidin-2-yl]-1,2,4-oxadiazole
• CAS: 681239-98-5
• 化学式: C₁₂H₁₃N₃O
• mdl: MFCD18265356
• 分子量: 215.255
• InChiKey: DAPALCXWAIUWGM-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  51
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (S)-5-Phenyl-3-(pyrrolidin-2-yl)-1,2,4-oxadiazole 、 (R)-N-叔丁氧羰基-3-氨基-4-(2-氟苯基)丁酸 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  The design of potent and selective inhibitors of DPP-4: Optimization of ADME properties by amide replacements

  摘要：

  For a series of beta-homophenylalanine based inhibitors of dipeptidyl peptidase IV ADME properties were improved by the incorporation of amide replacements. These efforts led to a novel series of potent and selective inhibitors of DPP-4 that exhibit an attractive pharmacokinetic profile and show excellent efficacy in an animal model of diabetes. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.078
• 作为产物：
  描述：

  tert-butyl (2S)-2-(5-phenyl-1,2,4-oxadiazol-3-yl)pyrrolidine-1-carboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 (S)-5-Phenyl-3-(pyrrolidin-2-yl)-1,2,4-oxadiazole
  参考文献：
  名称：

  The design of potent and selective inhibitors of DPP-4: Optimization of ADME properties by amide replacements

  摘要：

  For a series of beta-homophenylalanine based inhibitors of dipeptidyl peptidase IV ADME properties were improved by the incorporation of amide replacements. These efforts led to a novel series of potent and selective inhibitors of DPP-4 that exhibit an attractive pharmacokinetic profile and show excellent efficacy in an animal model of diabetes. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.078

文献信息

• The design of potent and selective inhibitors of DPP-4: Optimization of ADME properties by amide replacements
  作者：Sonja Nordhoff、Stephan Bulat、Silvia Cerezo-Gálvez、Oliver Hill、Barbara Hoffmann-Enger、Meritxell López-Canet、Claudia Rosenbaum、Christian Rummey、Meinolf Thiemann、Victor G. Matassa、Paul J. Edwards、Achim Feurer

  DOI：10.1016/j.bmcl.2009.09.078

  日期：2009.11

  For a series of beta-homophenylalanine based inhibitors of dipeptidyl peptidase IV ADME properties were improved by the incorporation of amide replacements. These efforts led to a novel series of potent and selective inhibitors of DPP-4 that exhibit an attractive pharmacokinetic profile and show excellent efficacy in an animal model of diabetes. (C) 2009 Elsevier Ltd. All rights reserved.