eprinomectin | 133305-88-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: eprinomectin
• 英文别名: eprinomectin B1a；Eprinomectin component B1a；N-[(2S,3R,4S,6S)-6-[(2S,3S,4S,6R)-6-[(1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-2-[(2S)-butan-2-yl]-21',24'-dihydroxy-3,11',13',22'-tetramethyl-2'-oxospiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-12'-yl]oxy-4-methoxy-2-methyloxan-3-yl]oxy-4-methoxy-2-methyloxan-3-yl]acetamide
• CAS: 133305-88-1
• 化学式: C₅₀H₇₅NO₁₄
• 分子量: 914.144
• InChiKey: ZKWQQXZUCOBISE-CRTGXIDZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  65
• 可旋转键数：
  9
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  179
• 氢给体数：
  3
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  eprinomectin 在 吡啶 、 咪唑 、 叔丁基过氧化氢 、 selenium(IV) oxide 、 氢氟酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Synthesis and Biological Activity of 4a,4"-Disubstituted Avermectins

  摘要：

  Allylic oxidation of avermectin B-1 and C-4''-substituted avermectin B-1 analogues at C-4a followed by derivatization of the C-4a oxygen provides compounds that have an improved safety profile, as judged by mouse LD(50) data, and are substantially more potent than avermectin B-1 against flies.

  DOI：

  10.1021/jf00044a041

文献信息

• Synergistic Combination of Glutamate-and Gaba-Gated Chloride Agonist Pesticide and at Least One Vitamin E, Niacin, or Derivatives Thereof
  申请人：Pedersen Morten

  公开号：US20090111759A1

  公开（公告）日：2009-04-30

  Presented are pesticidal compositions comprising at least one pesticide selected among Glutamate- or GABA-gated chloride channel agonist pesticides and at least one synergist which is selected among Vitamin E, Niacin and derivatives thereof. The combinations of these compounds show a synergistic effect allowing a composition to be prepared comprising a lesser amount of pesticide, while still controlling the harmful pests.

  提供的是杀虫组合物，包括至少一种从谷氨酸或GABA门控氯离子通道激动剂杀虫剂中选择的杀虫剂，以及至少一种从维生素E、烟酸及其衍生物中选择的协同剂。这些化合物的组合表现出协同效应，允许制备含较少杀虫剂的组合物，同时仍然控制有害的害虫。
• Anthelmintic compositions containing combinations of avermectins or milbemycins with bis-aryl compounds
  申请人：PFIZER INC.

  公开号：EP1066854A2

  公开（公告）日：2001-01-10

  Combinations of avermectins and milbemycins and their derivatives with bis-aryl compounds and their use in combating parasite, especially helminth, infections.

  阿维菌素和米贝菌素及其衍生物与双芳基化合物的组合及其在防治寄生虫（尤其是蠕虫）感染中的应用。
• Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin
  申请人：Cheminova A/S

  公开号：EP1849363A1

  公开（公告）日：2007-10-31

  Presented are pesticidal compositions comprising at least one compound A selected among Glutamate- or GABA-gated chloride channel agonist pesticides and at least one compound B which is selected among Vitamin E and Niacin. The combinations of these compounds show a synergistic effect in the control of harmful pests.

  所介绍的杀虫组合物包含至少一种选自谷氨酸或 GABA 门控氯离子通道激动剂杀虫剂的化合物 A 和至少一种选自维生素 E 和烟酸的化合物 B。这些化合物的组合在控制有害害虫方面显示出协同效应。
• Pesticidal compositions
  申请人：Cheminova A/S

  公开号：EP2033518A1

  公开（公告）日：2009-03-11

  Presented are pesticidal compositions comprising at least one pesticide selected among Glutamate- or GABA-gated chloride channel agonist pesticides and at least one synergist which is selected among long chain alcohols. The combinations of these compounds show a synergistic effect allowing a composition to be prepared comprising a lesser amount of pesticide, while still controlling the harmful pests.

  所介绍的杀虫组合物包含至少一种从谷氨酸或 GABA 门控氯离子通道激动剂杀虫剂中选出的杀虫剂和至少一种从长链醇中选出的增效剂。这些化合物的组合显示出协同增效作用，从而可以制备出含有较少杀虫剂的组合物，同时仍能控制有害害虫。
• Eprinomectin parenteral compositions
  申请人：Ceva Sante Animale

  公开号：EP3023092A1

  公开（公告）日：2016-05-25

  The invention relates to a parenteral composition, wherein the formulation comprises eprinomectin and a vehicle comprising dimethylsulfoxide. It also relates to said composition for use in the treatment of infections caused by ectoparasites and endoparasites.

  本发明涉及一种肠外组合物，其中制剂包括依普瑞菌素和由二甲基亚砜组成的载体。本发明还涉及用于治疗由体外寄生虫和体内寄生虫引起的感染的上述组合物。