Gentamicin, sulfate (salt)

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Gentamicin, sulfate (salt)
• 英文别名: (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-[(1R)-1-aminoethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-(aminomethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-[(1R)-1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
• 化学式: C60H125N15O25S
• 分子量: 1488.8
• InChiKey: RDEIXVOBVLKYNT-HDZPSJEVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -11.55
• 重原子数：
  101
• 可旋转键数：
  19
• 环数：
  9.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  710
• 氢给体数：
  26
• 氢受体数：
  40

反应信息

• 作为反应物：
  描述：

  碳酸氢钠 、 Gentamicin, sulfate (salt) 在 resveratrol 、 乙醇 、 alcohol 作用下， 反应 1.0h， 生成 resveratrol
  参考文献：
  名称：

  METHOD OF INHIBITING FORMATION OF NEISSERIA GONORRHEA AND NEISSERIA MENINGIDITIS

  摘要：

  本发明提供了一种抑制宿主细胞中假性狂犬病病毒颗粒形成的方法。该方法涉及向感染疱疹病毒的宿主细胞中投与有效量的多羟基苯乙烯，特别是白藜芦醇。本发明还提供了一种在体外和体内减少或抑制淋病奈瑟氏菌和脑膜炎奈瑟氏菌生长的方法。该方法包括向已经或可能与细菌接触的生长表面投与含有治疗有效量的三羟基苯乙烯的组合物。

  公开号：

  US20060035984A1

文献信息

• METHOD OF INHIBITING FORMATION OF NEISSERIA GONORRHEA AND NEISSERIA MENINGIDITIS
  申请人：Docherty John

  公开号：US20060035984A1

  公开（公告）日：2006-02-16

  The present invention provides a method of inhibiting the formation of pseudorabies particles in a host cell. The method involves administering an effective amount of a poly-hydroxylated stilbene, particularly resveratrol, to a herpes virus infected host cell. The present invention also provides a method of reducing or inhibiting the growth of Neisseria gonorrhea and Neisseria meningiditis in vitro and in vivo. The method comprises administering a composition comprising a therapeutically effective amount of a tri-hydroxylated stilbene to a growth surface which has come into contact or could come into contact with the bacterium.

  本发明提供了一种抑制宿主细胞中假性狂犬病病毒颗粒形成的方法。该方法涉及向感染疱疹病毒的宿主细胞中投与有效量的多羟基苯乙烯，特别是白藜芦醇。本发明还提供了一种在体外和体内减少或抑制淋病奈瑟氏菌和脑膜炎奈瑟氏菌生长的方法。该方法包括向已经或可能与细菌接触的生长表面投与含有治疗有效量的三羟基苯乙烯的组合物。
• Trans and cis traumatic acid salts having cicatrizant activity
  申请人：Lifegroup S.p.A.

  公开号：US05567716A1

  公开（公告）日：1996-10-22

  Traumatic acid salts, wherein B is a cation selected from: a) a quaternary ammonium, b) a cation of a linear or branched C.sub.1 -C.sub.20 mono-, di- or trialkanolamine, c) a cation of a biologically active primary, secondary or tertiary amine, d) silver or zinc cation, and relative pharmaceutical compositions administrable by topical or parenteral route For the therapeutic treatment of cutaneous pathologies in which it is important to associate an a bacteriostatic, antibiotic, antifungal or an antiviral activity, to the cicatrizant effect, typical of traumatic acid.

  创伤酸盐，其中B是从以下选择的阳离子：a）季铵盐，b）线性或支链C.sub.1-C.sub.20单，二或三烷基醇胺的阳离子，c）生物活性的一级、二级或三级胺的阳离子，d）银或锌阳离子，并且具有局部或静脉途径可给药的相关药物组合物，用于治疗皮肤病变，其中重要的是将抗菌，抗生素，抗真菌或抗病毒活性与创伤酸的愈合效果相结合。
• Method of inhibiting formation of infectious microorganisms
  申请人：Northeastern Ohio Universities College of Medicine

  公开号：US06355692B2

  公开（公告）日：2002-03-12

  The present invention provides a method of inhibiting the formation of pseudorabies particles in a host cell. The method involves administering an effective amount of a poly-hydroxylated stilbene, particularly resveratrol, to a herpes virus infected host cell. The present invention also provides a method of reducing or inhibiting the growth of Neisseria gonorrhea and Neisseria meningiditis in vitro and in vivo. The method comprises administering a composition comprising a therapeutically effective amount of a tri-hydroxylated stilbene to a growth surface which has come into contact or could come into contact with the bacterium.

  本发明提供了一种抑制宿主细胞中伪狂犬病病毒颗粒形成的方法。该方法涉及向感染疱疹病毒的宿主细胞中施加有效量的多羟基芪类，特别是白藜芦醇。本发明还提供了一种在体外和体内减少或抑制淋球菌和脑膜炎球菌生长的方法。该方法包括向与细菌接触或可能接触的生长表面施加含有治疗有效量的三羟基芪类的组合物。
• Method of inhibiting formation of infectious herpes virus particles
  申请人：Northeastern Ohio Universities College of Medicine

  公开号：US06197834B1

  公开（公告）日：2001-03-06

  The present invention provides a method of inhibiting the formation of infectious herpes virus particles, particularly infectious herpes simplex virus (HSV) particles, in a host cell. The method involves administering an effective amount of a hydroxylated stilbene, particularly resveratrol, to a herpes virus infected host cell. The present invention also provides a method of treating a herpes virus infection, particularly an HSV infection. The method comprises administering a topical composition comprising a therapeutically effective amount of a hydroxylated stilbene to a herpes virus-infected site. The present invention also relates to a topical composition for treating a herpes virus infection selected from the group consisting of an HSV infection, a cytomegalovirus infection, and a varicella zoster virus infection. The present invention also provides a method of reducing the cytopathic effect of HSV on mammalian cells. The method involves administering resveratrol to the host cell, either in vitro or in vivo, in an amount sufficient to inhibit replication of HSV-1 or HSV-2 within the host cell.

  本发明提供了一种抑制宿主细胞内感染性疱疹病毒颗粒（尤其是感染性单纯疱疹病毒（HSV）颗粒）形成的方法。该方法涉及向疱疹病毒感染的宿主细胞中投入有效量的羟基化芝樟烯，尤其是白藜芦醇。本发明还提供了一种治疗疱疹病毒感染，尤其是HSV感染的方法。该方法包括向疱疹病毒感染部位投入含有治疗有效量的羟基化芝樟烯的局部组合物。本发明还涉及用于治疗疱疹病毒感染的局部组合物，所述感染包括HSV感染、巨细胞病毒感染和水痘带状疱疹病毒感染。本发明还提供了一种减少HSV对哺乳动物细胞细胞病理学影响的方法。该方法涉及向宿主细胞中投入白藜芦醇，无论是体外还是体内，以足够抑制HSV-1或HSV-2在宿主细胞内复制的量。
• Method of inhibiting formation of Neisseria gonorrhea and Neisseria meningiditis
  申请人：Northeastern Ohio Universities College of Medicine

  公开号：US07037945B2

  公开（公告）日：2006-05-02

  The present invention provides a method of inhibiting the formation of pseudorabies particles in a host cell. The method involves administering an effective amount of a poly-hydroxylated stilbene, particularly resveratrol, to a herpes virus infected host cell. The present invention also provides a method of reducing or inhibiting the growth of Neisseria gonorrhea and Neisseria meningiditis in vitro and in vivo. The method comprises administering a composition comprising a therapeutically effective amount of a tri-hydroxylated stilbene to a growth surface which has come into contact or could come into contact with the bacterium.

  本发明提供了一种抑制宿主细胞中伪狂犬病病毒颗粒形成的方法。该方法涉及向疱疹病毒感染的宿主细胞施加有效量的多羟基苯乙烯，特别是白藜芦醇。本发明还提供了一种在体外和体内减少或抑制淋球菌和脑膜炎球菌生长的方法。该方法包括向与细菌接触或可能接触的生长表面施加含有治疗有效量的三羟基苯乙烯的组合物。