resveratrol | 133294-37-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: resveratrol
• 英文别名: 3,4',5-trihydroxystilbene；tocilizumab；3,5,4’-trihydroxystilbene；3,5,4'-trihydroxystilbene；1,3-Benzenediol, 5-[(1Z)-2-(4-hydroxyphenyl)ethenyl]-；5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
• CAS: 133294-37-8
• 化学式: C₁₄H₁₂O₃
• mdl: MFCD00133799
• 分子量: 228.247
• InChiKey: LUKBXSAWLPMMSZ-UHFFFAOYSA-N

物化性质

• 熔点：
  261 °C(Solv: water (7732-18-5))
• 沸点：
  449.1±14.0 °C(Predicted)
• 密度：
  1.359±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  resveratrol 在 二苯二硫醚 作用下， 以 四氢呋喃 为溶剂， 生成 白藜芦醇
  参考文献：
  名称：

  去铁醛（甲磺酸去铁胺）对过氧化物酶和漆酶的抑制作用

  摘要：

  摘要 研究了去铁胺（甲磺酸去铁胺），一种对铁的稳定常数为 10 31 的过渡金属螯合剂，对血红素蛋白过氧化物酶的催化活性以及铜蛋白、漆酶和儿茶酚氧化酶的催化活性的影响。结果表明去铁醛是过氧化物酶和漆酶活性的抑制剂，但不是儿茶酚氧化酶活性的抑制剂，其抑制特性强烈依赖于用于测量酶活性的酚类底物。因此，desferal 的抑制作用不依赖于假体组的性质。然而，它作为苯酚氧化酶（如过氧化物酶和漆酶）抑制剂的用途是有希望的，因为去铁胺似乎可以使这些酶的作用形成的苯氧基自由基失活。

  DOI：

  10.1016/0031-9422(95)00984-1
• 作为产物：
  描述：

  白藜芦醇 生成 resveratrol
  参考文献：
  名称：

  Recent advances of resveratrol in nanostructured based delivery systems and in the management of HIV/AIDS

  摘要：

  Resveratrol, a natural polyphenolic compound present in trees, in peanuts, in grapevines and exhibited multiple pharmacological activities. Extensive research in last two decades suggested that resveratrol possesses anti-inflammatory, anti-cancer, anti-viral, anti-amyloid, anti-arthritic and antioxidant properties. Some clinical reports have proposed that resveratrol might be a potential candidate for the prevention and/or treatment of HIV/AIDS and synergistically enhances the anti-HIV-1 activity. Resveratrol is not toxic to cells, and by itself reduces viral replication by 20% to 30%. With almost 12% of the world population suffering from HIV/AIDS including its resurgence in the developed world, better management of this global threat is highly desired. Further, various studies demonstrated several issues associated with resveratrol which account for its poor systemic bioavailability (almost zero) due to rapid and extensive first pass metabolism and existence of enterohepatic recirculation. In order to improve bioavailability and cellular uptake of resveratrol, various strategies have been adopted to date which includes resveratrol prodrug and the development of nanostructured delivery systems. Besides, nanostructured delivery systems are also known to inhibit the P-glycoprotein (P-gp) efflux, reduced metabolism by gut cytochrome P-450 enzymes, and circumnavigate the hepatic first-pass effect, facilitating absorption of drugs via intestinal lymphatic pathways. This review paper provides an updated bird's-eye view account on the publications and patents study on the recent novel approaches to deliver resveratrol in order to enhance oral bioavailability, overcome first pass metabolism and trounce enterohepatic recirculation to make resveratrol a therapeutically potent drug. Providing a relatively pithy overview, this paper thus presents recent advances of resveratrol for the treatment and prevention of HIV/AIDS. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jconrel.2014.09.002
• 作为试剂：
  描述：

  碳酸氢钠 、 Gentamicin, sulfate (salt) 在 resveratrol 、 乙醇 作用下， 反应 1.0h， 生成 resveratrol
  参考文献：
  名称：

  Method of inhibiting formation of infectious herpes virus particles

  摘要：

  本发明提供了一种抑制宿主细胞内感染性疱疹病毒颗粒（尤其是感染性单纯疱疹病毒（HSV）颗粒）形成的方法。该方法涉及向疱疹病毒感染的宿主细胞中投入有效量的羟基化芝樟烯，尤其是白藜芦醇。本发明还提供了一种治疗疱疹病毒感染，尤其是HSV感染的方法。该方法包括向疱疹病毒感染部位投入含有治疗有效量的羟基化芝樟烯的局部组合物。本发明还涉及用于治疗疱疹病毒感染的局部组合物，所述感染包括HSV感染、巨细胞病毒感染和水痘带状疱疹病毒感染。本发明还提供了一种减少HSV对哺乳动物细胞细胞病理学影响的方法。该方法涉及向宿主细胞中投入白藜芦醇，无论是体外还是体内，以足够抑制HSV-1或HSV-2在宿主细胞内复制的量。

  公开号：

  US06197834B1

文献信息

• Synthesis of Deuterated (<i>E</i>)-Alkene through Xanthate-Mediated Hydrogen–Deuterium Exchange Reactions
  作者：Jiaming Li、Jian Li、Xiaoliang Ji、Runfa He、Yang Liu、Zebin Chen、Yubing Huang、Qiang Liu、Yibiao Li

  DOI：10.1021/acs.orglett.1c02600

  日期：2021.10.1

  Herein we have developed a reversible hydrogen–deuterium exchange reaction of nonactivated olefins. By using EtOCS2K as a mediator, the H/D exchange reaction was realized through repeated addition and elimination reactions, demonstrating reversible H/D exchange between ordinary olefins and deuterated olefins. Using the lowest cost D2O without precious metal catalysts and ligands, a broad spectrum of

  在此，我们开发了非活化烯烃的可逆氢-氘交换反应。以EtOCS 2 K为介体，通过反复加成和消去反应实现H/D交换反应，证明了普通烯烃和氘化烯烃之间的H/D交换是可逆的。在没有贵金属催化剂和配体的情况下使用最低成本的 D 2 O，实现了广泛的官能团兼容性。
• MOLECULARLY IMPRINTED POLYMERS
  申请人：Hearn Milton T. W.

  公开号：US20120052757A1

  公开（公告）日：2012-03-01

  The present invention provides methods of designing molecularly imprinted polymers (MIPs) which have applications in extracting bioactive compounds from a range of bioprocessing feedstocks and wastes. The present invention is further directed to MIPs designed by the methods of the present invention.

  本发明提供了设计分子印迹聚合物（MIPs）的方法，这些方法在从各种生物加工原料和废弃物中提取生物活性化合物方面具有应用。本发明进一步针对由本发明方法设计的MIPs。
• 一种保健品白藜芦醇的制备方法
  申请人：安徽世华化工有限公司

  公开号：CN107337584A

  公开（公告）日：2017-11-10

  本发明提供一种保健品白藜芦醇的制备方法，1.本发明中使用的脱保护方法是绿色环保无污染的，该工艺基本无三废，产物1,4‑戊二烯还可产生一定的经济价值。2.本发明所用催化剂，循环重复性能良好，可达50次以上。3.本发明所涉及的方法操作要求简单，反应条件温和，专一性强，产物后处理提纯简单，适用于工业化生成。4.本发明所涉及方法制备的白藜芦醇无杂质，纯度极高。
• [EN] SIRT1 ACTIVATING COMPOUNDS<br/>[FR] COMPOSÉS D'ACTIVATION DE SIRT1
  申请人：HARVARD COLLEGE

  公开号：WO2020081654A1

  公开（公告）日：2020-04-23

  Provided herein are methods and compositions for preventing or treating aging, or an aging-related disorder, a disorder associated with inflammation, or for modulating an immune response in a subject in need thereof. In some embodiments, the methods comprise administering to the subject an effective amount of a compound of Formulas I-XIII.

  本文提供了用于预防或治疗衰老、衰老相关疾病、与炎症相关的疾病或调节需要者免疫反应的方法和组合物。在某些实施例中，这些方法包括向受试者施用化合物I-XIII的有效量。
• Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors
  作者：Andrea Angeli、Damiano Tanini、Caterina Viglianisi、Lucia Panzella、Antonella Capperucci、Stefano Menichetti、Claudiu T. Supuran

  DOI：10.1016/j.bmc.2017.03.013

  日期：2017.4

  A series of selenides, diselenides and organoselenoheterocycles were evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors against the human (h) isoforms hCA I, II, IV, VII and IX, involved in a variety of diseases among which glaucoma, retinitis pigmentosa, epilepsy, arthritis and tumors etc. These investigated compounds showed inhibitory action against these isoforms and some of them were selective

  一系列硒化物，二硒化物和有机硒杂环化合物被评估为碳酸酐酶（CA，EC 4.2.1.1）抑制剂，可抵抗人类（h）亚型hCA I，II，IV，VII和IX，涉及多种疾病，其中青光眼，这些研究的化合物显示出对这些同工型的抑制作用，其中一些对膜结合同工型具有抑制胞质的选择性，因此使它们成为开发同工型选择性抑制剂的有趣线索。