kanamycin | 717087-69-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: kanamycin
• 英文别名: (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol
• CAS: 717087-69-9
• 化学式: C₁₈H₃₆N₄O₁₁
• 分子量: 484.504
• InChiKey: SBUJHOSQTJFQJX-OEGCVRBXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.9
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  283
• 氢给体数：
  11
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  kanamycin 在 三乙胺 、 对甲苯磺酰氯 作用下， 以 吡啶 、 甲醇 为溶剂， 反应 10.0h， 生成
  参考文献：
  名称：

  HYDROPHOBICALLY ENHANCED AMINOGLYCOSIDES

  摘要：

  疏水增强型氨基糖苷类化合物已经制备并显示出有效的抗菌作用。这些化合物可以用于治疗或预防各种细菌感染。制备这些化合物的方法也便于合成。公式（I）。

  公开号：

  US20110178037A1

文献信息

• Synthesis of aminoglycoside–DNA conjugates
  作者：I. Charles、Liang Xue、Dev P. Arya

  DOI：10.1016/s0960-894x(02)00157-9

  日期：2002.5

  Development of aminoglycoside-nucleic acid conjugates is presented. Synthesis of a DNA dimer covalently linked to kanamycin and neomycin isothiocyanates has been carried out. The development of such conjugates will help couple the sequence specificity of nucleic acids to the electrostatic/shape complementarity of aminoglycoside antibiotics in binding nucleic acid targets.

  提出了氨基糖苷-核酸缀合物的开发。已经进行了与卡那霉素和新霉素异硫氰酸酯共价连接的DNA二聚体的合成。此类缀合物的开发将有助于将核酸的序列特异性与结合核酸靶标中氨基糖苷抗生素的静电/形状互补性相结合。
• T5 exonuclease-based method to identify DNA topoisomerase inhibitors
  申请人：Leng Fenfei

  公开号：US11268129B1

  公开（公告）日：2022-03-08

  The present invention provides assays and methods for studying DNA topology and topoisomerases. The assays and methods utilize a circular plasmid DNA comprising one or more hairpin structures and the ability of T5 exonuclease (T5E) to digest the circular plasmid DNA in a specific configuration. The assays and methods can be used as a high throughput screening for inhibitors of, for example, DNA gyrases and DNA topoisomerases I for anticancer drug and antibiotics discovery.

  本发明提供了研究DNA拓扑结构和拓扑异构酶的检测方法。这些检测方法利用包含一个或多个发夹结构的环状质粒 DNA 以及 T5 外切酶（T5E）以特定构型消化环状质粒 DNA 的能力。这些检测方法可用于高通量筛选 DNA 回旋酶和 DNA 拓扑异构酶 I 等的抑制剂，以发现抗癌药物和抗生素。
• 1H-NMR analysis of copper-aminoglycoside complexes in solution and its implication for regioselective modification of multifunctional aminoglycoside antibiotics
  作者：Ioannis Grapsas、Irina Massova、Shahriar Mobashery

  DOI：10.1016/s0040-4020(98)00407-4

  日期：1998.7

  A method for analysis of complexes of the cupric ion with aminoglycoside antibiotics based on the measurement of the paramagnetic contribution of the cupric ion to T-1 relaxation time on H-1-NMR spectra of the antibiotics is described. The information from the NMR experiments was supplemented by molecular modeling studies and proved valuable in predicting the reactivities of these complexes toward reagents for modification of amines, which were used in regioselective, and often regiospecific, derivatization of these important antibiotics. (C) 1998 Elsevier Science Ltd. All rights reserved.
• T5 EXONUCLEASE-BASED METHOD TO IDENTIFY DNA TOPOISOMERASE INHIBITORS
  申请人：LENG Fenfei

  公开号：US20220119858A1

  公开（公告）日：2022-04-21

  The present invention provides assays and methods for studying DNA topology and topoisomerases. The assays and methods utilize a circular plasmid DNA comprising one or more hairpin structures and the ability of T5 exonuclease (T5E) to digest the circular plasmid DNA in a specific configuration. The assays and methods can be used as a high throughput screening for inhibitors of, for example, DNA gyrases and DNA topoisomerases I for anticancer drug and antibiotics discovery.