3,4,5-tris-benzyloxy-6-(benzyloxymethyl)-tetrahydro-pyran-2-one | 366010-28-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,4,5-tris-benzyloxy-6-(benzyloxymethyl)-tetrahydro-pyran-2-one
• 英文别名: 3,4,5-Trisbenzyloxy-6-benzyloxymethyltetrahydropyran-2-one；3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-one
• CAS: 366010-28-8
• 化学式: C₃₄H₃₄O₆
• 分子量: 538.64
• InChiKey: BUBVLQDEIIUIQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  40
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3,4,5-tris-benzyloxy-6-(benzyloxymethyl)-tetrahydro-pyran-2-one 在 正丁基锂 、 水 、 氯化铵 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.42h， 以43%的产率得到3,4,5-tris-benzyloxy-6-benzyloxymethyl-2-[5-(4-ethylphenoxy)-2-trityloxymethylphenyl]tetrahydropyran-2-ol
  参考文献：
  名称：

  SPIROKETAL DERIVATIVE AND USE THEREOF AS DIABETIC MEDICINE

  摘要：

  公开号：

  EP1852439B1

文献信息

• [EN] 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES<br/>[FR] 4-BIARYLYL-1-PHÉNYLAZÉTIDIN-2-ONES
  申请人：MICROBIA INC

  公开号：WO2005047248A1

  公开（公告）日：2005-05-26

  4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of a general formula (I) in which formula (II) represents an aryl or heteroaryl residue, Ar represents an aryl residue; U is a two to six atom chain; and the R’s represent substituents.

  4-双苯基-1-苯基氮杂环丁烷-2-酮，用于治疗高胆固醇血症的化合物被披露。这些化合物具有通用公式(I)，其中公式(II)代表一个芳基或杂芳基残基，Ar代表一个芳基残基；U是2到6个原子的链；而R's代表取代基。
• [EN] BENZOCYCLOBUTANE DERIVATIVES USEFUL AS DUAL SGLT1/SGLT2 MODULATORS<br/>[FR] DÉRIVÉS DE BENZOCYCLOBUTANE UTILES EN TANT QUE MODULATEURS DOUBLES DE SGLT1/SGLT2
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2018089449A1

  公开（公告）日：2018-05-17

  The present invention is directed to benzocyclobutane derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by SGLT activity, more particularly dual SGLT1/2 activity. More particularly, the compounds of the present invention are useful in the treatment of for example, Type II diabetes mellitus, Syndrome X, and complications and symptoms associated with said disorders.

  本发明涉及苯并环丁烷衍生物，含有它们的药物组合物以及它们在治疗由SGLT活性调节的疾病和症状中的应用，更具体地说是双重SGLT1/2活性。更具体地说，本发明的化合物在治疗例如II型糖尿病、X综合征以及与这些疾病相关的并发症和症状中是有用的。
• Novel Glucitol Derivative, Prodrug Thereof And Salt Thereof, And Therapeutic Agent Containing The Same For Diabetes
  申请人：Matsuoka Hiroharu

  公开号：US20080319047A1

  公开（公告）日：2008-12-25

  The invention provides a glucitol derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): wherein m is an integer selected among 1-3; R 1 to R 4 each independently is optionally substituted alkyl, etc.; Ar1 is optionally substituted naphthyl; and A is optionally substituted heteroaryl, a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, and the like each containing the compound.

  本发明提供了一种葡萄糖醇衍生物，具有降低血糖水平的功能，并具有药物所需的优良性质，例如持久的药物活性；以及用于预防或治疗由高血糖引起的疾病，例如糖尿病、糖尿病并发症和肥胖症的药物组合物。该衍生物是由式(I)表示的化合物：其中m是在1-3之间选择的整数；R1至R4各自独立地是可选的取代烷基等；Ar1是可选的取代萘基；A是可选的取代杂环芳基、该化合物的前药或其药学上可接受的盐。还提供了含有该化合物的药物、药物组合物等。
• SPIROKETAL DERIVATIVES AND USE THEREOF AS DIABETIC MEDICINE
  申请人：Kobayashi Takamitsu

  公开号：US20090030006A1

  公开（公告）日：2009-01-29

  The present invention provides a compound of Formula (I): wherein R 1 , R 2 , R 3 and R 4 are each independently selected from a hydrogen atom, an optionally substituted C 1 -C 6 alkyl group, an optionally substituted C 7 -C 14 aralkyl group and —C(═O)Rx; Rx represents an optionally substituted C 1 -C 6 alkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C 1 -C 6 alkoxy group or —NReRf; Ar 1 represents an optionally substituted aromatic carbocyclic ring or an optionally mono-substituted aromatic heterocyclic ring; Q represents —(CH 2 ) m -(L) p - or -(L) p -(CH 2 ) m —; m represents an integer selected from 0 to 2, n represents an integer selected from 1 and 2, and p represents an integer selected from 0 and 1; L represents —O—, —S— or —NR 5 —; and A represents an optionally substituted aryl group or an optionally substituted heteroaryl group, a prodrug thereof and a pharmaceutically acceptable salt thereof, as well as a pharmaceutical preparation or pharmaceutical composition comprising such a compound.

  本发明提供了一种化合物，其化学式为(I)，其中R1、R2、R3和R4各自独立地选自氢原子、可选取代的C1-C6烷基、可选取代的C7-C14芳基烷基和—C(═O)Rx；Rx代表可选取代的C1-C6烷基、可选取代的芳基、可选取代的杂环芳基、可选取代的C1-C6烷氧基或—NReRf；Ar1代表可选取代的芳香环烷基或可选单取代的芳香杂环烷基；Q代表—(CH2)m-(L)p-或-(L)p-(CH2)m—；m代表选自0至2的整数，n代表选自1和2的整数，p代表选自0和1的整数；L代表—O—、—S—或—NR5—；A代表可选取代的芳基或可选取代的杂环芳基，以及该化合物的前药和药学上可接受的盐，以及包含该化合物的制药制备或制药组合物。
• Synthesis of Glycerolipid Carbamates and Dicarbamates and Their Use as an Antitumor Compounds
  申请人：Bittman Robert

  公开号：US20090042811A1

  公开（公告）日：2009-02-12

  The syntheses and in vitro antitumor properties of carbamate-containing, dicarbamate-containing, and ureido-containing phospholipid compounds that have an ether linkage at the C-1 position of a glycerol backbone, a carbamate, dicarbamate, or ureido moiety at the C-2 position of the glycerol backbone, and a phosphocholine, phosphonocholine, or glycoside moiety at the C-3 position of the glycerol backbone are described. The synthesis and antiproliferative activity of ether lipids with a naphthol moiety at the C-1 position are also described. These compounds were shown to be potent inhibitors of cancer cell growth. These compounds are useful for killing cancer cells and treating cancer.

  本文描述了在甘油骨架的C-1位置具有醚键的氨基甲酸酯，双氨基甲酸酯和尿素含有物，C-2位置具有氨基甲酸酯，双氨基甲酸酯或尿素基团，并在C-3位置具有磷酸胆碱，磷酸胆碱或糖苷基团的磷脂化合物的合成和体外抗肿瘤性质。 本文还描述了在C-1位置具有萘酚基团的醚脂类化合物的合成和抗增殖活性。这些化合物被证明具有强大的抑制癌细胞生长的能力。这些化合物可用于杀死癌细胞和治疗癌症。