3-(1-苯乙氨基)丙酸 | 95350-05-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-(1-苯乙氨基)丙酸
• 英文名称: N-phenylethyl-β-alanine
• 英文别名: 3-(1-phenylethylazaniumyl)propanoate
• CAS: 95350-05-3
• 化学式: C₁₁H₁₅NO₂
• mdl: MFCD00509401
• 分子量: 193.246
• InChiKey: QYOGWZCNJDREPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990

反应信息

• 作为反应物：
  描述：

  3-(1-苯乙氨基)丙酸 在 四丁基硫酸氢铵 potassium hydrogencarbonate 、 甲基磺酰氯 作用下， 以 氯仿 、 水 为溶剂， 反应 24.0h， 以30%的产率得到1-(α-phenylethyl)-2-azetidinone
  参考文献：
  名称：

  Synthesis of 1-(?-phenylethyl)azetidin-2-ones

  摘要：

  DOI：

  10.1007/bf00505958
• 作为产物：
  描述：

  丙烯酸 、 α-苯乙胺 以 吡啶 为溶剂， 以52%的产率得到3-(1-苯乙氨基)丙酸
  参考文献：
  名称：

  Synthesis of 1-(?-phenylethyl)azetidin-2-ones

  摘要：

  DOI：

  10.1007/bf00505958

文献信息

• WRINKLE-IMPROVING AGENT
  申请人：Shiseido Company, Limited

  公开号：EP1941861A1

  公开（公告）日：2008-07-09

  The invention provides a novel wrinkle-improving agent that has an effect of improving wrinkles, that does not entail problems of safety or pain even when applied to the skin, and that contains a very safe substance as an active component. A discovery was made that N-benzoyl-β-alanine, other specific β-alanine derivatives, and salts thereof have a wrinkle-improving effect, whereby a wrinkle-improving agent containing as an active component one, two, or more types of compounds selected from the group composed of these specific β-alanine derivatives and the salts thereof was developed.

  该发明提供了一种新型的改善皱纹的剂，具有改善皱纹的效果，即使应用于皮肤也不会带来安全或疼痛问题，并且包含一种非常安全的物质作为活性成分。发现N-苯甲酰-β-丙氨酸、其他特定的β-丙氨酸衍生物及其盐具有改善皱纹的效果，因此开发了一种改善皱纹的剂，其活性成分包含从这些特定的β-丙氨酸衍生物及其盐组成的群体中选择的一种、两种或更多种化合物。
• Parakeratosis inhibitor, pore -shrinking agent and external compositon for skin
  申请人：Kaminuma Mikiko

  公开号：US20120232111A1

  公开（公告）日：2012-09-13

  The invention provides a parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent that has a function such as parakeratosis inhibition, pore shrinkage, or rough skin—inhibition/abatement, poses no safety problems such as sensory irritation, and is very safe, and further provides an external composition for skin to which a compound having the above-mentioned function has been added. The parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent comprises one or more compounds selected from the group consisting of β-alanine derivatives and salts thereof. The external composition for skin comprises the one or more compounds selected from the group consisting of β-alanine derivatives and salts thereof as the above-mentioned parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent.

  本发明提供了一种角化过度抑制剂、毛孔收缩剂或粗糙肌肤预防/改善剂，具有诸如角化过度抑制、毛孔收缩或粗糙肌肤抑制/减轻等功能，不会引起感觉刺激等安全问题，非常安全，还提供了一种外用皮肤组成物，其中添加了具有上述功能的化合物。该角化过度抑制剂、毛孔收缩剂或粗糙肌肤预防/改善剂包括从β-丙氨酸衍生物和其盐的群组中选择的一种或多种化合物。该外用皮肤组成物包括上述β-丙氨酸衍生物和其盐中的一种或多种作为上述角化过度抑制剂、毛孔收缩剂或粗糙肌肤预防/改善剂。
• CALCIUM RECEPTOR-ACTIVE MOLECULES
  申请人：NPS Pharmaceuticals, Inc.

  公开号：US20130190407A1

  公开（公告）日：2013-07-25

  The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca 2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.

  本发明涉及无机离子受体在细胞和身体过程中的不同作用。 本发明的特点包括：（1）分子可以调节一个或多个无机离子受体的活性，最好是分子可以模拟或阻断细胞上的无机离子受体对细胞外离子的影响，更好的是细胞外离子是Ca2 +，其影响是在具有钙受体的细胞上; （2）无机离子受体蛋白及其片段，最好是钙受体蛋白及其片段; （3）编码无机离子受体蛋白及其片段的核酸，最好是编码钙受体蛋白及其片段的核酸; （4）针对无机离子受体蛋白的抗体及其片段，最好是钙受体蛋白; 以及（5）使用这些分子，蛋白质，核酸和抗体。
• PARAKERATOSIS INHIBITOR, PORE-SHRINKING AGENT AND EXTERNAL COMPOSITION FOR SKIN
  申请人：Shiseido Company, Limited

  公开号：EP1880711A1

  公开（公告）日：2008-01-23

  The invention provides a parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent that has a function such as parakeratosis inhibition, pore shrinkage, or rough skin -inhibition/abatement, poses no safety problems such as sensory irritation, and is very safe, and further provides an external composition for skin to which a compound having the above-mentioned function has been added. The parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent comprises one or more compounds selected from the group consisting of β-alanine derivatives and salts thereof. The external composition for skin comprises the one or more compounds selected from the group consisting of β-alanine derivatives and salts thereof as the above-mentioned parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent.

  本发明提供了一种角化抑制剂、毛孔收缩剂或皮肤粗糙预防/改善剂，它具有抑制角化、收缩毛孔或皮肤粗糙抑制/改善等功能，不会造成感官刺激等安全问题，而且非常安全，并进一步提供了一种添加了具有上述功能的化合物的皮肤外用组合物。角化抑制剂、毛孔收缩剂或皮肤粗糙预防/改善剂包括一种或多种选自 β-丙氨酸衍生物及其盐类的化合物。皮肤外用组合物包括选自由 β-丙氨酸衍生物及其盐组成的组的一种或多种化合物，作为上述角化病抑制剂、毛孔收缩剂或皮肤粗糙预防/改善剂。
• PROCESS FOR THE SYNTHESIS OF IBANDRONATE SODIUM
  申请人：Cipla Limited

  公开号：EP2038291B1

  公开（公告）日：2010-07-14