2-(3-chlorophenyl)-1H-indole-3-carbaldehyde

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(3-chlorophenyl)-1H-indole-3-carbaldehyde
• 化学式: C₁₅H₁₀ClNO
• 分子量: 255.703
• InChiKey: NXBHSITUAMCMLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(3-chlorophenyl)-1H-indole-3-carbaldehyde 、 联苯甲酰 在 ammonium acetate 、 溶剂黄146 作用下， 以50%的产率得到2-(3-chlorophenyl)-3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole
  参考文献：
  名称：

  Triarylimidazoles-synthesis of 3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives as potent α-glucosidase inhibitors

  摘要：

  A series of new trisubstituted imidazoles-3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives (2a-2u) were synthesized and evaluated for their alpha-glucosidase inhibition. The new compounds showed significant alpha-glucosidase inhibitory activity as compared to the standard inhibitor acrabose. Structures of synthesized compounds were determined using FT-IR, Mass spectrometry, H-1 NMR, C-13 NMR, and elemental analyses.

  DOI：

  10.1007/s00044-014-1239-y
• 作为产物：
  描述：

  N-benzyl-2-((3-chlorophenyl)ethynyl)aniline 、 N,N-二甲基甲酰胺 在 copper(II) trifluoroacetate hydrate 、 氧气 作用下， 反应 24.0h， 以44%的产率得到
  参考文献：
  名称：

  铜 (ii) 催化的邻炔基苯胺与 DMF 的环状甲酰化：3-甲酰基吲哚的一步策略†

  摘要：

  在本文中，铜( II ) 催化的邻炔基苯胺与二甲基甲酰胺(DMF) 在氧气存在下的反应已被开发用于合成多取代的3-甲酰基吲哚支架。这种一锅法反应通过级联 5- endo -dig 环化然后甲酰化来构建 1,2-二取代的 3-甲酰基吲哚。这种合成方法的关键方面是广泛的底物范围（38 个例子），以及对各种官能团的耐受性。此外，还提出了一种详细的机制，其中 DMF 可以作为碳源，用于所得吲哚衍生物的原位C3 甲酰化。

  DOI：

  10.1039/c8ra09214a

文献信息

• Atroposelective Synthesis of Planar‐Chiral Indoles via Carbene Catalyzed Macrocyclization
  作者：Gongming Yang、Yi He、Tianyi Wang、Zhipeng Li、Jian Wang

  DOI：10.1002/anie.202316739

  日期：2024.1.15

  atroposelective synthesis of macrocyclic planar-chiral indoles via NHC-catalyzed intramolecular macrocyclization is reported. In addition, the indole-based macrocycles bearing both planar and axial chirality have also been constructed via kinetic resolution. Importantly, these obtained planar-chiral macrocycles provide additional possibilities to develop novel catalysts or ligands, as well as new reactions.

  报道了通过 NHC 催化的分子内大环化反应选择性合成大环平面手性吲哚。此外，还通过动力学拆分构建了具有平面和轴向手性的吲哚基大环化合物。重要的是，这些获得的平面手性大环化合物为开发新型催化剂或配体以及新反应提供了额外的可能性。
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577B1

  公开（公告）日：2018-12-12
• BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Gouliaev Alex Haahr

  公开号：US20130281324A1

  公开（公告）日：2013-10-24

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.