methyl 3-amino-6-vinylpyrazine-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: methyl 3-amino-6-vinylpyrazine-2-carboxylate
• 英文别名: methyl 3-amino-6-ethenylpyrazine-2-carboxylate；Methyl 3-amino-6-ethenylpyrazine-2-carboxylate
• 化学式: C₈H₉N₃O₂
• 分子量: 179.178
• InChiKey: VKQFZMDFJZXQIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  78.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 3-amino-6-vinylpyrazine-2-carboxylate 在 2,6-二甲基吡啶 、 4-二甲氨基吡啶 、 sodium periodate 、 四氧化锇 、 一水合肼 、 三氟乙酸 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 、 二氯甲烷 、 水 、 二甲基亚砜 、 叔丁醇 为溶剂， 反应 24.33h， 生成 methyl 3-amino-6-(2,2,2-trifluoroethyl)pyrazine-2-carboxylate
  参考文献：
  名称：

  [EN] INHIBITORS OF MENIN-MLL INTERACTION
  [FR] INHIBITEURS DE L'INTERACTION MÉNINE-MLL

  摘要：

  The present invention is directed to the compounds of Formula (I) – inhibitors of the interaction of menin and MLL. The inhibitors described herein can be useful in the treatment of diseases or disorders associated with menin-MLL interaction, such as cancer. In particular, the invention is concerned with compounds and pharmaceutical compositions inhibiting/blocking menin-MLL interaction, methods of treating diseases or disorders associated with menin-MLL interaction, and methods of synthesizing these compounds.

  公开号：

  WO2023107687A1
• 作为产物：
  描述：

  3-氨基-6-溴吡嗪-2-甲酸甲酯 、 乙烯三氟硼酸钾 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 以75 %的产率得到methyl 3-amino-6-vinylpyrazine-2-carboxylate
  参考文献：
  名称：

  [EN] INHIBITORS OF MENIN-MLL INTERACTION
  [FR] INHIBITEURS DE L'INTERACTION MÉNINE-MLL

  摘要：

  The present invention is directed to the compounds of Formula (I) – inhibitors of the interaction of menin and MLL. The inhibitors described herein can be useful in the treatment of diseases or disorders associated with menin-MLL interaction, such as cancer. In particular, the invention is concerned with compounds and pharmaceutical compositions inhibiting/blocking menin-MLL interaction, methods of treating diseases or disorders associated with menin-MLL interaction, and methods of synthesizing these compounds.

  公开号：

  WO2023107687A1

文献信息

• COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
  申请人：Vertex Pharmaceuticals Inc.

  公开号：EP2569286B1

  公开（公告）日：2014-08-20
• WO2024059096A2
  申请人：——

  公开号：——

  公开（公告）日：——
• [EN] INHIBITORS OF MENIN-MLL INTERACTION<br/>[FR] INHIBITEURS DE L'INTERACTION MÉNINE-MLL
  申请人：[en]BALA THERAPEUTICS, INC.

  公开号：WO2023107687A1

  公开（公告）日：2023-06-15

  The present invention is directed to the compounds of Formula (I) – inhibitors of the interaction of menin and MLL. The inhibitors described herein can be useful in the treatment of diseases or disorders associated with menin-MLL interaction, such as cancer. In particular, the invention is concerned with compounds and pharmaceutical compositions inhibiting/blocking menin-MLL interaction, methods of treating diseases or disorders associated with menin-MLL interaction, and methods of synthesizing these compounds.