4-(3,4-dihydroquinolin-1(2H)-ylsulfonyl)-N-(6-methylbenzo[d]thiazol-2-yl)benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(3,4-dihydroquinolin-1(2H)-ylsulfonyl)-N-(6-methylbenzo[d]thiazol-2-yl)benzamide
• 英文别名: N-(6-methyl-1,3-benzothiazol-2-yl)-4-(1,2,3,4-tetrahydroquinoline-1-sulfonyl)benzamide；4-(3,4-dihydro-2H-quinolin-1-ylsulfonyl)-N-(6-methyl-1,3-benzothiazol-2-yl)benzamide
• 化学式: C₂₄H₂₁N₃O₃S₂
• mdl: MFCD02697315
• 分子量: 463.581
• InChiKey: IAOLSOGPLAFUJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  116
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-((3,4-dihydroquinolin-1(2H)-yl)sulfonyl)benzoic acid 、 2-氨基-6-甲基苯并噻唑 在 乙酸乙酯 、 hexanes 作用下， 以to give 4-(3,4-dihydroquinolin-1(2H)-ylsulfonyl)-N-(6-methylbenzo[d]thiazol-2-yl)benzamide as a white solid的产率得到4-(3,4-dihydroquinolin-1(2H)-ylsulfonyl)-N-(6-methylbenzo[d]thiazol-2-yl)benzamide
  参考文献：
  名称：

  METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL

  摘要：

  本文提供了新型化合物和制药组合物，可用于减少Wnt介导的影响和治疗癌症等方法。

  公开号：

  US20120046250A1

文献信息

• Methods and compositions useful in treating cancer and reducing Wnt mediated effects in a cell
  申请人：Orton Darren

  公开号：US08901306B2

  公开（公告）日：2014-12-02

  Provided herein are novel compounds, pharmaceutical compositions for use, inter alia, in methods of reducing Wnt-mediated effects and treating cancer.

  本文提供了新型化合物、药物组合物，可用于减少Wnt介导的效应和治疗癌症等方法。
• Methods and compositions useful in treating cancer and reducing WNT mediated effects in a cell
  申请人：STEMSYNERGY THERAPEUTICS, INC.

  公开号：US09416101B2

  公开（公告）日：2016-08-16

  Provided herein are novel compounds, pharmaceutical compositions for use, inter alia, in methods of reducing Wnt-mediated effects and treating cancer.

  本文提供了新颖化合物和制药组合物，可用于减少Wnt介导的效应和治疗癌症等方法。
• PROCESS OF PREPARATION OF A N-ARYL BENZYL SULFONAMIDE SUBSTITUTED WITH AN AMIDO GROUP
  申请人：StemSynergy Therapeutics, Inc.

  公开号：EP3626240A1

  公开（公告）日：2020-03-25

  Provided herein are novel compounds, pharmaceutical compositions for use, inter alia, in methods of reducing Wnt-mediated effects and treating cancer.

  本文提供的新型化合物、药物组合物，除其他外，可用于降低 Wnt 介导的效应和治疗癌症的方法。
• METHODS AND COMPOSITIONS FOR USE IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL
  申请人：StemSynergy Therapeutics, Inc.

  公开号：EP2403499B1

  公开（公告）日：2019-09-18
• USE OF COLLAGEN BINDING DOMAINS TO DELIVER PRODUCTS TO SKIN
  申请人：Fabius Biotechnology

  公开号：US20210338558A1

  公开（公告）日：2021-11-04

  The present invention addresses the need for an improved delivery system that is able to specifically target the skin for improved bioavailability and minimization of side effects resulting from administration of the active ingredient or ingredients. One aspect of the present invention is a targeting composition comprising: (1) a skin care agent or an agent that is a cosmeceutical agent; (2) an intermediate release linker bound to the skin care agent or cosmeceutical agent; (3) a targeting moiety bound to the intermediate release linker, the targeting moiety for binding the targeting composition to native collagen fibers; and (4) optionally, a carrier component to enhance delivery to the skin. The present invention also describes methods of use of these targeting compositions.