3-(p-Chlor-benzoyl)-5-hydroxy-benzofuran | 17249-67-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(p-Chlor-benzoyl)-5-hydroxy-benzofuran
• 英文别名: (4-chloro-phenyl)-(5-hydroxy-benzofuran-3-yl)-methanone；(4-Chlorophenyl)(5-hydroxy-1-benzofuran-3-yl)methanone；(4-chlorophenyl)-(5-hydroxy-1-benzofuran-3-yl)methanone
• CAS: 17249-67-1
• 化学式: C₁₅H₉ClO₃
• mdl: MFCD00430818
• 分子量: 272.688
• InChiKey: IKYCNGBYJXSLOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(p-Chlor-benzoyl)-5-hydroxy-benzofuran 在 一水合肼 作用下， 以 甲醇 为溶剂， 反应 6.0h， 以70%的产率得到2-[5-(4-chlorophenyl)-1H-pyrazol-4-yl]benzene-1,4-diol
  参考文献：
  名称：

  Unexpected ring-opening of 3-aroylbenzo[b]furans at room temperature: a new route for the construction of phenol-substituted pyrazoles

  摘要：

  A new and convenient route for the synthesis of phenol-substituted pyrazoles 11-18 is starting from 3-aroylbenzo[b]furans 1-8 and hydrazine hydrate at room temperature. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.04.085

文献信息

• NOGO RECEPTOR BINDING SMALL MOLECULES TO PROMOTE AXONAL GROWTH
  申请人：Yale University

  公开号：EP2220499A2

  公开（公告）日：2010-08-25
• Nogo Receptor Binding Small Molecules to Promote Axonal Growth
  申请人：Strittmatter Stephen M.

  公开号：US20110065715A1

  公开（公告）日：2011-03-17

  The present invention provides a method for identifying compounds which modulate the interaction of Nogo and Nogo receptor (NgR). The present invention also provides compounds that modulate the interaction of Nogo and Nogo receptor (NgR), the use of such compounds and compositions in the treatment or amelioration of conditions diseases or disorders, such as spinal cord injury, traumatic brain injury, stroke, multiple sclerosis, ALS, Huntington's disease, Alzheimer's disease, Parkinson's disease, epilepsy, Schizophrenia or schizoaffective disorders.
• [EN] NOGO RECEPTOR BINDING SMALL MOLECULES TO PROMOTE AXONAL GROWTH<br/>[FR] PETITES MOLÉCULES SE LIANT AU RÉCEPTEUR NOGO POUR PROMOUVOIR LA CROISSANCE AXONALE
  申请人：STRITTMATTER STEPHEN M

  公开号：WO2009073141A2

  公开（公告）日：2009-06-11

  The present invention provides a method for identifying compounds which modulate the interaction of Nogo and Nogo receptor (NgR). The present invention also provides compounds that modulate the interaction of Nogo and Nogo receptor (NgR), the use of such compounds and compositions in the treatment or amelioration of conditions diseases or disorders, such as spinal cord injury, traumatic brain injury, stroke, multiple sclerosis, ALS, Huntington's disease, Alzheimer's disease, Parkinson's disease, epilepsy, Schizophrenia or schizoaffective disorders.
• Unexpected ring-opening of 3-aroylbenzo[b]furans at room temperature: a new route for the construction of phenol-substituted pyrazoles
  作者：Hatem A. Abdel-Aziz、Pervez Ahmad、Adnan Kadi、Khalid A. Al-Rashood、Hazem A. Ghabbour、Hoong-Kun Fun

  DOI：10.1016/j.tetlet.2013.04.085

  日期：2013.6

  A new and convenient route for the synthesis of phenol-substituted pyrazoles 11-18 is starting from 3-aroylbenzo[b]furans 1-8 and hydrazine hydrate at room temperature. (C) 2013 Elsevier Ltd. All rights reserved.