7-chloro-4-hydroxy-6-methyl-quinoline-3-carboxylic acid ethyl ester | 127720-02-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-chloro-4-hydroxy-6-methyl-quinoline-3-carboxylic acid ethyl ester
• 英文别名: 7-Chlor-4-hydroxy-6-methyl-chinolin-3-carbonsaeure-aethylester；ethyl 7-chloro-6-methyl-4-oxo-1H-quinoline-3-carboxylate
• CAS: 127720-02-9
• 化学式: C₁₃H₁₂ClNO₃
• 分子量: 265.696
• InChiKey: BHMKLCVKDCEBRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-chloro-4-hydroxy-6-methyl-quinoline-3-carboxylic acid ethyl ester 在 sodium hydroxide 、 二苯醚 、 联苯 作用下， 生成 7-chloro-6-methyl-quinolin-4-ol
  参考文献：
  名称：

  喹啉; 一些4-氨基喹啉衍生物。

  摘要：

  DOI：

  10.1021/ja01192a030
• 作为产物：
  描述：

  2-((3-氯-4-甲基苯基氨基)亚甲基)丙二酸二乙酯 在 mineral oil 作用下， 生成 7-chloro-4-hydroxy-6-methyl-quinoline-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  喹啉; 一些4-氨基喹啉衍生物。

  摘要：

  DOI：

  10.1021/ja01192a030

文献信息

• CHATTOPADHYAY, JAYANTA;BASU, S. K., INDIAN J. CHEM. B , 29,(1990) N, C. 98-100
  作者：CHATTOPADHYAY, JAYANTA、BASU, S. K.

  DOI：——

  日期：——
• THE TREATMENT OF SEXUAL DYSFUNCTION AND CARDIOVASCULAR DISEASE WITH QUINOLINONE ENANTIOMERS
  申请人：R.T. Alamo Ventures I, LLC

  公开号：EP1355647A2

  公开（公告）日：2003-10-29
• [EN] THE TREATMENT OF SEXUAL DYSFUNCTION AND CARDIOVASCULAR DISEASE WITH QUINOLINONE ENANTIOMERS<br/>[FR] TRAITEMENT DE TROUBLES SEXUELS ET DE MALADIE CARDIO-VASCULAIRE AVEC DES ENANTIOMERES QUINOLINONE
  申请人：R T ALAMO VENTURES I LLC

  公开号：WO2002058703A2

  公开（公告）日：2002-08-01

  Methods for treating specific patient groups for sexual dysfunction are provided. The methods of the present invention comprise the utilization of enantiomers of flosequinan, and pharmaceutical compositions comprising flosequinan enantiomers, in patients who are free of cardiac disease, who have not been treated with a drug that causes hypotensive effects, and/or who have not been given organic nitrites or nitrates. Flosequinan enantiomers, and pharmaceutical compositions comprising flosequinan enantiomers are administered to patients intranasally, orally, topically, and/or through respiratory inhalation. Additionally, the present invention is directed to compositions and methods for treating cardiovascular disease. In a preferred embodiment, the present invention contemplates using the enantiomers of flosequinan (and formulations comprising flosequinan) in subjects not concurrently treated with nitrites or nitrates.
• Chattopadhyay; Basu, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1990, vol. 29, # 1, p. 98 - 100
  作者：Chattopadhyay、Basu

  DOI：——

  日期：——
• Quinolines VI. Some 4-Aminoquinoline Derivatives
  作者：Edgar A. Steck、Louis L. Hallock、C. M. Suter

  DOI：10.1021/ja01192a030

  日期：1948.12