2-Methyl-5-phenylamino-benzothiazole-4,7-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methyl-5-phenylamino-benzothiazole-4,7-dione
• 英文别名: 2-Methyl-5-(phenylamino)benzothiazole-4,7-dione；5-anilino-2-methyl-1,3-benzothiazole-4,7-dione
• 化学式: C₁₄H₁₀N₂O₂S
• 分子量: 270.312
• InChiKey: VZPGJVVDMFSGJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  87.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  苯胺 、 5-甲氧基-2-甲基-4,7-苯并噻唑二酮 以 乙醇 为溶剂， 反应 5.0h， 生成 2-Methyl-5-phenylamino-benzothiazole-4,7-dione
  参考文献：
  名称：

  Synthesis and antifungal activities of 5/6-arylamino-4,7-dioxobenzothiazoles

  摘要：

  5/6-Arylamino-4,7 -dioxobenzothiazoles were synthesized and tested for in vitro antifungal activities against pathogenic fungi. Most of the tested 4,7-dioxobenzothiazoles exhibited potent antifungal activities against Candida species and Aspergillus niger (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00301-2

文献信息

• Three hybrid assay system
  申请人：GPC Biotech AG

  公开号：EP1975620A2

  公开（公告）日：2008-10-01

  The invention provides compositions and methods for isolating ligand binding polypeptides for a user-specified ligand, and for isolating small molecule ligands for a user-specified target polypeptide using an improved class of hypbrid ligand compounds.

  本发明提供了用于分离用户指定配体的配体结合多肽的组合物和方法，以及使用改良的低杂合配体化合物分离用户指定目标多肽的小分子配体的组合物和方法。
• 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents
  作者：Chung-Kyu Ryu、Hye-Young Kang、Sang Kook Lee、Kyung Ae Nam、Chang Yong Hong、Won-Gil Ko、Byung-Hoon Lee

  DOI：10.1016/s0960-894x(00)00014-7

  日期：2000.3

  5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines, (C) 2000 Elsevier Science Ltd. All rights reserved.
• Synthesis and antifungal activities of 5/6-arylamino-4,7-dioxobenzothiazoles
  作者：Chung-Kyu Ryu、Hye-Young Kang、Yu-Jin Yi、Keun-Hwa Shin、Byung-Hoon Lee

  DOI：10.1016/s0960-894x(00)00301-2

  日期：2000.7

  5/6-Arylamino-4,7 -dioxobenzothiazoles were synthesized and tested for in vitro antifungal activities against pathogenic fungi. Most of the tested 4,7-dioxobenzothiazoles exhibited potent antifungal activities against Candida species and Aspergillus niger (C) 2000 Elsevier Science Ltd. All rights reserved.