D-Glucurono-6,2-lactone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-Glucurono-6,2-lactone
• 英文别名: (2S,3S,4S,5S)-3,4,5-trihydroxy-6-oxooxane-2-carbaldehyde
• 化学式: C₆H₈O₆
• 分子量: 176.12
• InChiKey: JBQGSJDKHSBLDG-MBMOQRBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  D-Glucurono-6,2-lactone 、 水 生成 D-glucuronate 、 氢(+1)阳离子
  参考文献：
  名称：

  WINKELMAN J.; LEHNINGER A.L., J Biol Chem, 1958, 0021-9258, 794-9

  摘要：

  DOI：

文献信息

• Polysaccharide, and water absorbent, moisture absorbent or humectant and thickening agent chiefly made of the polysaccharide, and cultivation method of producing it by a microorganism
  申请人：HAKUTO CORPORATION

  公开号：EP0379999A1

  公开（公告）日：1990-08-01

  Water absorbent, moisture absorbent, or humectant and thickening agent chiefly made of the polysaccharide having high biodegradability and can be used without causing potential environmental hazards such as secondary pollution, said polysaccharide consisting essentially of rhamnose, fucose, glucose,mannose and glucuronic acid which are present in a molar ratio of (1 - 10):(2 - 10):(4 - 20):(1):(1 - 5), and being produced by cultivating a microorganism with a mono­saccharide or disaccharide being selectively used as a carbon source in a culture medium.

  吸水剂、吸湿剂或保湿剂和增稠剂，主要由具有高生物降解性的多糖制成，可在不造成二次污染等潜在环境危害的情况下使用，所述多糖主要由鼠李糖、岩藻糖、葡萄糖、甘露糖和葡萄糖醛酸组成，其摩尔比为(1 - 10):(2 - 10):(4 - 20):(1):(1 - 5)：(2 - 10):(4 - 20):(1):(1 - 5) 的摩尔比，并通过在培养基中选择性地使用单糖或双糖作为碳源培养微生物而产生。
• Extended wear ophthalmic lens
  申请人：Novartis AG

  公开号：EP1043605A1

  公开（公告）日：2000-10-11

  An ophthalmic lens is disclosed which is suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of an oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

  本发明公开了一种眼科镜片，这种镜片适合在眼睛上长时间佩戴至少一天，而不会出现临床上明显的角膜肿胀，也不会使佩戴者感到严重不适。该镜片具有氧气渗透性和离子或水渗透性的平衡，其中离子或水渗透性足以提供良好的眼球运动，从而在镜片和眼睛之间进行良好的泪液交换。一种优选的镜片是氧珀大单体和离子珀单体的共聚产物。本发明包括延戴型隐形眼镜，它包括一个镜芯，镜芯具有从内表面延伸到外表面的氧气传输和离子传输通道。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• Extended wear contact lens
  申请人：Novartis AG

  公开号：EP2270550A2

  公开（公告）日：2011-01-05

  An ophthalmic lens is disclosed which is suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of an oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

  本发明公开了一种眼科镜片，这种镜片适合在眼睛上长时间佩戴至少一天，而不会出现临床上明显的角膜肿胀，也不会使佩戴者感到严重不适。该镜片具有氧气渗透性和离子或水渗透性的平衡，其中离子或水渗透性足以提供良好的眼球运动，从而在镜片和眼睛之间进行良好的泪液交换。一种优选的镜片是氧珀大单体和离子珀单体的共聚产物。本发明包括延戴型隐形眼镜，它包括一个镜芯，镜芯具有从内表面延伸到外表面的氧气传输和离子传输通道。
• RECOMBINANT YEAST STRAINS
  申请人：Modern Meadow, Inc.

  公开号：EP3460046A1

  公开（公告）日：2019-03-27

  This invention relates to genetically engineered strains of yeast and methods for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of α ketoglutarate.

  本发明涉及基因工程酵母菌株和生产重组蛋白（如胶原蛋白）的方法。本发明的重组蛋白可用于生产生物人造革或具有类似皮革特性的材料，其中含有重组胶原蛋白或工程胶原蛋白。对酵母菌株进行改造，以生产抗坏血酸和/或增加 α 酮戊二酸的产量。