Magnesium ethoxide

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机氧化物
• 英文名称: Magnesium ethoxide
• 英文别名: magnesium;ethanolate
• 化学式: C4H10MgO2
• 分子量: 114.43
• InChiKey: XDKQUSKHRIUJEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.65
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Magnesium ethoxide 生成 氢氧化镁
  参考文献：
  名称：

  HOMENY, J.;LEWIS, D.;RICE, R. W.;GARINO, T., FRACT. MECH. CERAM.: 1ST PT PROC. 4TH INT. SYMP., BLACKSBURG, VA, JUNE 19+

  摘要：

  DOI：
• 作为产物：
  描述：

  乙醇 生成 Magnesium ethoxide
  参考文献：
  名称：

  CHAPUT, FREDERIC;BOILOT, JEAN-PIERRE;LEJEUNE, MARTINE;PAPIERNIK, RENEE;HU+, J. AMER. CERAM. SOC., 72,(1989) N, C. 1355-1357

  摘要：

  DOI：
• 作为试剂：
  描述：

  2-氨基-3-氧代-丁酸乙酯盐酸盐 、 ethyl butyrimidate 在 Magnesium ethoxide 、 三乙胺 、 水 、 乙酸乙酯 、 resultant residue 、 乙醚 作用下， 以 乙醇 为溶剂， 反应 48.0h， 以to afford the title compound (4.05 g)的产率得到5-甲基-2-丙基-3H-咪唑-4-羧酸乙酯
  参考文献：
  名称：

  Benzofuran derivatives

  摘要：

  该发明提供了通式（I）的化合物及其生理上可接受的盐、溶剂或非毒性代谢不稳定酯，其中R.sup.1代表卤素原子；Ar代表基团##STR2## R.sup.3代表C-连接的四唑基团；R.sup.4和R.sup.5可以相同也可以不同，分别独立地代表氢原子或卤素原子或C.sub.1-6烷基；Het代表N-连接的咪唑基团，可在2位取代。这些化合物可用于治疗或预防高血压和与认知障碍相关的疾病。

  公开号：

  US05374646A1

文献信息

• Thiol carboxylic acid derivatives and their use as colagenase inhibitors
  申请人：Beecham Group p.l.c.

  公开号：US04937243A1

  公开（公告）日：1990-06-26

  Novel compounds of the formula (I), processes for their preparation and their use as collagenase inhibitors are described: ##STR1## in which R.sub.1 is hydroxy; alkoxy; aryloxy; aralkyloxy; --NR.sub.6 R.sub.7 where R.sub.6 and R.sub.7 are hydrogen or alkyl, or R.sub.6 and R.sub.7 together with the N-atom to which they are bonded form a 5- to 7-membered ring with an optional heteroatom; --NHCH(R.sub.8)COR.sub.9 where R.sub.8 is hydrogen; alkyl optionally substituted by hydroxy, alkoxy, --NR.sub.6 R.sub.7, quanidine, CO.sub.2 H, CONH.sub.2, SH, or S-alkyl; or CH.sub.2 -AR where Ar is optionally substituted aryl; and R.sub.9 is hydroxy, alkoxy or --NR.sub.6 R.sub.7. R.sub.2 is hydrogen or acyl. R.sub.3 is C.sub.3-6 alkyl. R.sub.4 is hydrogen; alkyl; --CH.sub.2 R.sub.10 where R.sub.10 is optionally substituted phenyl or heteroaryl; or --CH(R.sub.12)O--R.sub.11 where R.sub.11 is hydrogen; alkyl; or --CH.sub.2 Ph where Ph is optionally substituted phenyl; and R.sub.12 is hydrogen or alkyl. R.sub.5 is hydrogen; alkyl; or --CH(R.sub.13)COR.sub.14 where R.sub.13 is hydrogen or alkyl; and R.sub.14 is hydroxy, alkoxy or --NR.sub.6 R.sub.7.

  本发明涉及一种化合物的新结构式（I），以及制备它们的过程和它们作为胶原酶抑制剂的用途： 其中，R1是羟基；烷氧基；芳氧基；芳基烷氧基；--NR6R7，其中R6和R7是氢或烷基，或者R6和R7与它们连接的N原子形成一个5-至7-成员环，其中可选的杂原子；--NHCH（R8）COR9，其中R8是氢；烷基可选地被羟基，烷氧基，--NR6R7，鸟氨酸，CO2H，CONH2，SH或S-烷基取代；或CH2-AR，其中Ar是可选的取代芳基；R9是羟基，烷氧基或--NR6R7。R2是氢或酰基。R3是C3-6烷基。R4是氢；烷基；-- R10，其中R10是可选的取代苯基或杂原子基；或--CH（R12）O--R11，其中R11是氢；烷基；或-- Ph，其中Ph是可选的取代苯基；R12是氢或烷基。R5是氢；烷基；或--CH（R13）COR14，其中R13是氢或烷基；R14是羟基，烷氧基或--NR6R7。
• Mass treatment of cellulosic materials
  申请人：FMC Corporation

  公开号：US05208072A1

  公开（公告）日：1993-05-04

  This invention provides a process for deacidifying paper by contacting the paper with hydrocarbon or halocarbon solutions of certain magnesium and/or zinc alkoxyalkoxides which may have been treated with carbon dioxide to yield low viscosity solutions.

  本发明提供了一种通过将纸张与某些镁和/或锌烷氧基烷氧基化合物的烃或卤代烃溶液接触来脱酸纸张的方法，这些化合物可能已经经过二氧化碳处理以产生低粘度溶液。
• Intermediates for certain 4-oxoquinoline-3-carboxylic acid derivatives
  申请人：Sanko Company, Limited

  公开号：US05436367A1

  公开（公告）日：1995-07-25

  Compounds of formula (I): ##STR1## (in which: R.sup.1 represents fluorinated methoxy; R.sup.2 represents a nitrogen-containing heterocyclic group and R.sup.3 represents hydrogen or amino) and pharmaceutically acceptable salts, esters and amides thereof are valuable antibacterial agents, which may be prepared by reacting a compound similar to that of formula (I) but in which R.sup.2 is replaced by a halogen atom with a compound providing the required group R.sup.2.

  式(I)的化合物：##STR1##（其中：R.sup.1代表氟代甲氧基；R.sup.2代表含氮杂环基团；R.sup.3代表氢或氨基），以及其药学上可接受的盐、酯和酰胺是有价值的抗菌剂，可以通过将类似于式(I)中R.sup.2被卤素原子取代的化合物与提供所需的基团R.sup.2的化合物反应制备而成。
• Processes for the production of thienopyrimidine derivatives
  申请人：——

  公开号：US20030055269A1

  公开（公告）日：2003-03-20

  The present invention provides a process for producing an intermediate for thienopyrimidine derivatives having the GnRH antagonistic activity at an industrial large scale. The process for production of the present invention relates to a process for producing a compound represented by the formula (III): 1 wherein respective symbols have the same meanings as those described below, or a salt thereof, which comprises subjecting a compound represented by the formula (I): 2 wherein R 1 denotes hydrogen, nitro, halogen, phthalimido, mono- or di-(alkylcarbonyl)amino or alkoxy, or a salt thereof, to an acid halogenating reaction, which is successively reacted with malonic acid ester and magnesium alkoxide, treated with an acid, and reacted with sulfur and a compound represented by the formula: NCCH 2 COOR 2 [wherein R 2 denotes alkyl or aryl], or a salt thereof, in the presence of primary amine. According to the process of production of the present invention, thienopyrimidine derivatives having the GnRH antagonistic activity can be produced effectively and at an industrial large scale by a high yield and simple method.

  本发明提供了一种在工业大规模下生产具有GnRH拮抗活性的噻唑嘧啶衍生物中间体的方法。本发明的生产方法涉及生产以下化合物的方法（III）：其中各符号具有以下所述的相同含义，或其盐，包括将化合物（I）：其中R1表示氢，硝基，卤素，邻苯二甲酰亚胺，单个或二个（烷基羰基）氨基或烷氧基，或其盐，经过酸卤化反应，随后与丙二酸酯和镁烷氧化物反应，用酸处理，然后与硫和化合物（II）：NCCH2COOR2（其中R2表示烷基或芳基），或其盐，在原始胺的存在下反应。根据本发明的生产方法，通过高产率和简单的方法，可以有效地在工业大规模下生产具有GnRH拮抗活性的噻唑嘧啶衍生物。
• Certain 1-phenyl-3-alkyl-1,3-propanediones
  申请人：Stauffer Chemical Company

  公开号：US04741769A1

  公开（公告）日：1988-05-03

  Compounds of the formula ##STR1## wherein R is halogen; C.sub.1 -C.sub.2 alkyl; C.sub.1 -C.sub.2 alkoxy; nitro; cyano; C.sub.1 -C.sub.2 haloalkyl; or R.sup.a SO.sub.n -- wherein n is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl; R.sup.1 is C.sub.1 -C.sub.4 alkyl; R.sup.2 is C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; R.sup.3 and R.sup.4 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub.1 -C.sub.4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C.sub.1 -C.sub.4 haloalkyl; (9) R.sup.b SO.sub.n -- wherein n is the intger 0, 1 or 2; and R.sup.b is (a) C.sub.1 -C.sub.4 alkyl; (b) C.sub.1 -C.sub.4 alkyl substituted with halogen or cyano; (c) phenyl; or (d) benzyl; (10) --NR.sup.c R.sup.d wherein R.sup.c and R.sup.d independently are hydrogen or C.sub.1 -C.sub.4 alkyl; (11) R.sup.e C(O)-- wherein R.sup.e is C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; or (12) --SO.sub.2 NR.sup.c R.sup.d wherein R.sup.c and R.sup.d are as defined; and (13) --N(R.sup.c)C(O)R.sup.d wherein R.sup.e and R.sup.d are as defined and their salts are useful as herbicides.

  化合物的公式为##STR1##其中R为卤素；C.sub.1-C.sub.2烷基；C.sub.1-C.sub.2烷氧基；硝基；氰基；C.sub.1-C.sub.2卤代烷基；或R.sup.a SO.sub.n--其中n为0或2且R.sup.a为C.sub.1-C.sub.2烷基；R.sup.1为C.sub.1-C.sub.4烷基；R.sup.2为C.sub.1-C.sub.4烷基或C.sub.1-C.sub.4烷氧基；R.sup.3和R.sup.4分别独立地为(1)氢；(2)卤素；(3)C.sub.1-C.sub.4烷基；(4)C.sub.1-C.sub.4烷氧基；(5)三氟甲氧基；(6)氰基；(7)硝基；(8)C.sub.1-C.sub.4卤代烷基；(9)R.sup.b SO.sub.n--其中n为整数0、1或2；R.sup.b为(a)C.sub.1-C.sub.4烷基；(b)用卤素或氰基取代的C.sub.1-C.sub.4烷基；(c)苯基；或(d)苄基；(10)--NR.sup.c R.sup.d其中R.sup.c和R.sup.d独立地为氢或C.sub.1-C.sub.4烷基；(11)R.sup.e C(O)--其中R.sup.e为C.sub.1-C.sub.4烷基或C.sub.1-C.sub.4烷氧基；或(12)--SO.sub.2 NR.sup.c R.sup.d其中R.sup.c和R.sup.d如定义；和(13)--N(R.sup.c)C(O)R.sup.d其中R.sup.e和R.sup.d如定义，它们的盐对除草剂有用。

表征谱图