10-甲基吖啶-10-鎓-1-胺氯化物 | 75605-59-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 10-甲基吖啶-10-鎓-1-胺氯化物
• 中文别名: 1H-咪唑-1-甲酰胺,2-乙基-4-甲基-N-苯基-
• 英文名称: 1-amino-10-methylacridinium chloride
• 英文别名: 10-Methylacridin-1(10H)-imine--hydrogen chloride (1/1)；10-methylacridin-1-imine;hydrochloride
• CAS: 75605-59-3
• 化学式: C₁₄H₁₃N₂*Cl
• 分子量: 244.724
• InChiKey: ILNXSUDQAPWFJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  29.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  10-甲基吖啶-10-鎓-1-胺氯化物 在 sodium azide 、 sodium nitrite 作用下， 生成 1-叠氮基-10-甲基吖啶-10-鎓氯化物
  参考文献：
  名称：

  Identification of an acridine photoaffinity probe for trypanocidal action

  摘要：

  Twenty-four acridine derivatives were screened for trypanocidal activity in Trypanosoma brucei in order to determine which structural features of the acridine molecule confer maximal antiparasitic activity. The synthesis of several new azidoacridine derivatives are also reported as well as an assessment of their value as possible photoaffinity probes for the study of acridine trypanocidal action. The most effective and selective acridine trypanocides, with and without irradiation, were the 3-amino-10-methylacridinium salt derivatives. With brief irradiation, one azidoacridine, 3-amino-6-azido-10-methylacridinium chloride, showed considerable trypanocidal activity at very limiting drug concentrations (10(-7)M) and warrants consideration as a possible photoaffinity probe.

  DOI：

  10.1021/jm00373a010

文献信息

• Desinfektionsmittel und ihre Verwendung zur Haut- und Schleimhautdesinfektion
  申请人：Henkel Kommanditgesellschaft auf Aktien

  公开号：EP0252278A2

  公开（公告）日：1988-01-13

  Die Erfindung betrifft flüssige, wasserhaltige Desin­fektionsmittel auf Basis Alkohol und Wasserstoffper­oxid, die einen oder mehrere Alkohole mit 2 bis 8 C-­Atomen, Wasserstoffperoxid oder eine in wäßriger Phase Peroxid bildende Verbindung, eine oder mehrere Carbon­säuren, eine oder mehrere mikrobizid wirksame stick­stoffhaltige organische Verbindungen, eine oder mehre­re mikrobizid wirksame phenolische Verbindungen, gege­benenfalls noch weitere, in Desinfektionsmitteln vor­handene Wirkstoffe und/oder Hilfsstoffe und Wasser enthalten, sowie die Verwendung derartiger Desinfek­tionsmittel zur Haut- und Schleimhautdesinfektion.

  本发明涉及基于醇和过氧化氢的液态含水消毒剂，其中含有一种或多种具有 2 至 8 个碳原子的醇、过氧化氢或在水相中形成过氧化物的化合物、一种或多种羧酸、一种或多种微苦味活性含氮有机化合物、一种或多种微苦味活性酚类化合物、消毒剂中可选择的其他活性成分和/或辅助物质以及水、一种或多种微苦味活性含氮有机化合物、一种或多种微苦味活性酚类化合物、消毒剂和水中的其他活性成分和/或辅助物质，以及使用这些消毒剂对皮肤和粘膜进行消毒。
• Identification of an acridine photoaffinity probe for trypanocidal action
  作者：William J. Firth、Andrew Messa、Robert Reid、Rung Chou Wang、Charles L. Watkins、Lerena W. Yielding

  DOI：10.1021/jm00373a010

  日期：1984.7

  Twenty-four acridine derivatives were screened for trypanocidal activity in Trypanosoma brucei in order to determine which structural features of the acridine molecule confer maximal antiparasitic activity. The synthesis of several new azidoacridine derivatives are also reported as well as an assessment of their value as possible photoaffinity probes for the study of acridine trypanocidal action. The most effective and selective acridine trypanocides, with and without irradiation, were the 3-amino-10-methylacridinium salt derivatives. With brief irradiation, one azidoacridine, 3-amino-6-azido-10-methylacridinium chloride, showed considerable trypanocidal activity at very limiting drug concentrations (10(-7)M) and warrants consideration as a possible photoaffinity probe.