5,7,2',5'-tetrahydroxyflavone | 847032-33-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 5,7,2',5'-tetrahydroxyflavone
• 英文别名: 2-(2,5-Dihydroxyphenyl)-6,7-dihydroxychromen-4-one
• CAS: 847032-33-1
• 化学式: C₁₅H₁₀O₆
• 分子量: 286.241
• InChiKey: JLGXLUZKYNLHEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 5,7,2',5'-tetrahydroxyflavone 以 吡啶 为溶剂， 以0.05 g的产率得到5,7,2',5'-tetraacetoxyflavone
  参考文献：
  名称：

  Bhardwaj, D. K.; Chand, Gyan; Jain, R. K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1982, vol. 21, p. 838 - 841

  摘要：

  DOI：
• 作为产物：
  描述：

  2,5-二甲氧基苯甲酰氯 在 氢氧化钾 、 三氯化铝 、 sodium acetate 作用下， 以 吡啶 、 溶剂黄146 、 苯 为溶剂， 反应 11.0h， 生成 5,7,2',5'-tetrahydroxyflavone
  参考文献：
  名称：

  Bhardwaj, D. K.; Chand, Gyan; Jain, R. K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1982, vol. 21, p. 838 - 841

  摘要：

  DOI：

文献信息

• Compositions of flavonoids and flavonoid-containing extracts and the treatment of diseases
  申请人：Gong Qiang Bang

  公开号：US20050049206A1

  公开（公告）日：2005-03-03

  In this invention, we describe a group of flavonoids and flavonoid-containing extracts that have pharmaceutical properties which are useful in the medicinal therapy of fibrotic diseases for the treatment or reparation and prevention of fibrotic lesional tissues. Representative flavonoids and flavonoid-containing extracts have the active compositions of the below formula. Those compositions can be extracted and purified from the botanicals, including Scutellaria baicalensis Georgi, Scutellaria scordifolia Fisch,Oroxylum indicum(L.) Vent, Plantago major L. The compositions of the invention are novel as an anti-fibrotic drugs, as agents for treating fibrosis.

  在这项发明中，我们描述了一组黄酮类化合物和含黄酮类化合物的提取物，具有药物特性，可用于治疗纤维化疾病的药物疗法，用于治疗、修复和预防纤维化病变组织。代表性的黄酮类化合物和含黄酮类化合物的提取物具有以下公式的活性成分。这些成分可以从植物中提取和纯化，包括黄芩、紫花地丁、橙黄木、车前草等。本发明的成分作为抗纤维化药物和治疗纤维化的药剂是新颖的。
• [EN] COMPOSITIONS OF FLAVONOIDS AND FLAVONOID-CONTAINING EXTRACTS AND THE TREATMENT OF DISEASES<br/>[FR] COMPOSITIONS DE FLAVONOIDES ET D'EXTRAITS QUI CONTIENNENT DES FLAVONOIDES, ET TRAITEMENT DE MALADIES
  申请人：SHANGHAI COMMAN PHARMACEUTICAL

  公开号：WO2005020881A2

  公开（公告）日：2005-03-10

  In this invention we describe a group of flavonoids and flavonoid-containing extracts that have pharmaceutical properties which are useful in the medicinal therapy of fibrotic diseases for the treatment or reparation and prevention of fibrotic lesional tissues. Representative flavonoids and flavonoid-containing extracts have the active compositions of the below formula (I). Those compositions can be extracted and purified from the botanicals, including Scutellaria baicalensis Georgi, Scutellaria scordifolia Fish, Oroxylum indicum (L.) Vent, Plantago major L. The compositions of the invention are novel as an anti-fibrotic drugs, as agents for treating fibrosis.
• Bhardwaj, D. K.; Chand, Gyan; Jain, R. K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1982, vol. 21, p. 838 - 841
  作者：Bhardwaj, D. K.、Chand, Gyan、Jain, R. K.、Munjal, Anita

  DOI：——

  日期：——