7-Pentoxy-1H-quinolin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-Pentoxy-1H-quinolin-2-one
• 化学式: C14H17NO2
• InChiKey: KHOPPTSXKSJURQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  42.09
• 氢给体数：
  1.0
• 氢受体数：
  2.0

文献信息

• METHODS FOR PREPARING BREXPIPRAZOLE, KEY INTERMEDIATES THEREOF AND SALTS THEREOF
  申请人：SUZHOU VIGONVITA LIFE SCIENCES CO., LTD.

  公开号：US20160272624A1

  公开（公告）日：2016-09-22

  The present invention relates to the methods for preparing brexpiprazole, the analogs, key intermediates, and salts thereof, specifically, the present invention relates to a new method for preparing brexpiprazole, the analogs, key intermediates, and salts thereof, and the key intermediates, and salts thereof provided during the preparation. The preparation method has a mild reaction condition, stable intermediate, easy operation, and uses cheap and easy-to-get reagents, thus it saves the synthesis cost, shortens the production cycle, improves the yield and product quality, and is suitable for mass production.

  本发明涉及制备布瑞匹噻唑的方法，其类似物，关键中间体和盐，具体地，本发明涉及一种制备布瑞匹噻唑，其类似物，关键中间体和盐的新方法，并在制备过程中提供的关键中间体和盐。该制备方法具有温和的反应条件，稳定的中间体，易操作，并使用便宜且易获得的试剂，因此节省了合成成本，缩短了生产周期，提高了产量和产品质量，并适用于大规模生产。
• METHOD FOR PRODUCING BENZO[B]THIOPHENE COMPOUND
  申请人：Shinhama Koichi

  公开号：US20140187782A1

  公开（公告）日：2014-07-03

  The present invention provides a method for producing a compound of Formula (4): wherein R 1 is a hydrogen atom etc. by reacting a compound of Formula (2): wherein X 1 is a leaving group, with a compound of Formula (3): wherein R 1 is as defined above, in the presence of (a) a palladium compound and a tertiary phosphine or (b) a palladium carbene complex, in an inert solvent or without a solvent. The present invention can produce the compound of Formula (4), with high purity and high yield, and by a simple operation.

  本发明提供了一种制备公式（4）化合物的方法：其中R1为氢原子等，通过在惰性溶剂中或不使用溶剂的情况下，在存在（a）钯化合物和三级膦或（b）钯卡宾配合物的情况下，通过将公式（2）化合物：其中X1是离去基团，与公式（3）化合物：其中R1如上定义，反应。本发明可以通过简单的操作，高纯度和高收率地制备公式（4）化合物。
• METHODS FOR PREPARING BREXPIPRAZOLE, KEY INTERMEDIATES THEREOF AND SALTS THEREOF
  申请人：Suzhou Vigonvita Life Sciences Co. Ltd.

  公开号：EP3059237A1

  公开（公告）日：2016-08-24

  The present invention relates to the methods for preparing brexpiprazole, the analogs, key intermediates, and salts thereof, specifically, the present invention relates to a new method for preparing brexpiprazole, the analogs, key intermediates, and salts thereof, and the key intermediates, and salts thereof provided during the preparation. The preparation method has a mild reaction condition, stable intermediate, easy operation, and uses cheap and easy-to-get reagents, thus it saves the synthesis cost, shortens the production cycle, improves the yield and product quality, and is suitable for mass production.

  本发明涉及布来哌唑、其类似物、关键中间体及其盐的制备方法，具体而言，本发明涉及一种新的布来哌唑、其类似物、关键中间体及其盐的制备方法，以及制备过程中提供的关键中间体及其盐。 该制备方法反应条件温和，中间体稳定，操作简便，试剂廉价易得，节省合成成本，缩短生产周期，提高收率和产品质量，适合大规模生产。
• PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BENZO[B]THIOPHENE COMPOUNDS
  申请人：Crystal Pharma S.A.U

  公开号：EP3150591A1

  公开（公告）日：2017-04-05

  A process for preparing compounds of formula (I), or a salt or solvate thereof, including Brexpiprazole, which process comprises cyclization of a compound of formula (II) or (III), or a salt or solvate thereof. The invention also refers to intermediates of said process.

  一种制备式(I)化合物或其盐或溶液，包括布雷希哌唑的工艺，该工艺包括式(II)或(III)化合物或其盐或溶液的环化。本发明还涉及上述工艺的中间体。
• US9206169B2
  申请人：——

  公开号：US9206169B2

  公开（公告）日：2015-12-08