7-Amino-2-methylheptan-2-ol | 44958-49-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7-Amino-2-methylheptan-2-ol
• CAS: 44958-49-8
• 化学式: C₈H₁₉NO
• mdl: MFCD19215830
• 分子量: 145.245
• InChiKey: GYEXXERLGUUFNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-chloro-6-(5-methyl-1H-pyrazol-3-ylamino)-4-methylnicotinonitrile 、 7-Amino-2-methylheptan-2-ol 在 碳酸氢钠 作用下， 以 二甲基亚砜 为溶剂， 生成 2-(6-hydroxy-6-methylheptylamino)-4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
  参考文献：
  名称：

  3-Cyano-6-(5-methyl-3-pyrazoloamino)pyridines: Selective Aurora A kinase inhibitors

  摘要：

  A new class of Aurora A kinase inhibitor was created by transforming 4-(5-methyl-3-pyrazoloamino)pyrimidine moiety of VX-680 to 3-cyano-6-(5-methyl-3pyrazoloamino)pyridine. Compound 6 exhibited a potent Aurora A kinase inhibitory activity, excellent selectivity to Aurora B kinase and other 60 kinases, good cell permeability and good PK profile. Therefore compound 6 was effective in antitumor mice model at a dose of 30 mg/kg po qd without decrease of body weight. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2010.04.119

文献信息

• METHOD FOR PRODUCING AN AMINE
  申请人：Kubanek Petr

  公开号：US20090286977A1

  公开（公告）日：2009-11-19

  Processes comprising: (i) providing a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones and mixtures thereof; and (ii) reacting the reactant with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a catalyst comprising a zirconium dioxide- and nickel-containing catalytically active composition, to form an amine; wherein the catalytically active composition, prior to reduction with hydrogen, comprises oxygen compounds of zirconium, copper, nickel and cobalt, and one or more oxygen compounds of one or more metals selected from the group consisting of Pb, Bi, Sn, Sb and In.

  包括以下步骤：(i) 提供从一次醇、二次醇、醛、酮及其混合物中选择的反应物；和(ii) 在存在包含氧化锆和镍的催化剂的催化活性组分的条件下，将反应物与氢气和从氨、一次胺、二次胺及其混合物中选择的氮化合物反应，生成胺；其中催化活性组分在与氢气还原之前，包括锆、铜、镍和钴的氧化物，以及从铅、铋、锡、锑和铟中选择的一个或多个金属的一个或多个氧化物。
• Hydrophile, hochquellfähige Hydrogele
  申请人：HOECHST AKTIENGESELLSCHAFT

  公开号：EP0671418A2

  公开（公告）日：1995-09-13

  Die vorliegende Erfindung betrifft ein hydrophiles, hochquellfähiges Hydrogel auf Basis (co)polymerisierter hydrophiler Monomerer oder auf Basis von Pfropf(co)polymerer, dadurch gekennzeichnet, daß es mit einem Polyamidoamin in wäßrigem Medium nachvernetzt ist. oam

  本发明涉及一种基于亲水单体（共）聚合或基于接枝（共）聚合物的亲水性高溶胀性水凝胶，其特点是在水介质中与聚酰胺胺进行后交联。 oam
• Method of improving the electrical conductivity of a shaped resin article and an electrostatic coating process
  申请人：DAI-ICHI KOGYO SEIYAKU CO., LTD.

  公开号：EP0732706A2

  公开（公告）日：1996-09-18

  A nitrogen-containing compound of the following general formula (1) is kneaded into a resin molding material, the kneaded mixture is molded and the surface of the resulting article is subjected to corona discharge treatment. Further, a coating material having electrostatic charges is sprayed and deposited on the article after the corona discharge treatment. This can provide a shaped resin article with remarkably improved electrical conductivity from a less electrically conductive resin, without substantially deteriorating the physical properties and the color of the article. Further, electrostatic coating excellent in coating efficiency, surface appearance, productivity or the like is possible. where R1 represents an alkyl group or alkenyl group of 5 to 21 carbon atoms, R2 represents -H or -CH3, R3 and R4 may be the same or different and each represents an alkyl group of 1 to 4 carbon atoms, A represents -(CH2)n- or and n is 1 to 5.

  将以下通式（1）的含氮化合物捏合到树脂成型材料中，然后将捏合混合物成型，并对成型物品的表面进行电晕放电处理。此外，在电晕放电处理后，在制品上喷涂和沉积具有静电荷的涂层材料。这样就可以用导电性较差的树脂制成导电性能显著提高的成型树脂制品，而不会严重影响制品的物理性能和颜色。此外，静电涂层在涂层效率、表面外观、生产率等方面也有可能得到改善。 其中 R1 代表 5 至 21 个碳原子的烷基或烯基，R2 代表-H 或-CH3，R3 和 R4 可以相同或不同，且各自代表 1 至 4 个碳原子的烷基，A 代表-(CH2)n- 或-(CH2)n-，n 为 1 至 5。 且 n 为 1 至 5。
• VERFAHREN ZUR HERSTELLUNG VON POLYURETHAN-SCHAUMSTOFFEN
  申请人：BASF AKTIENGESELLSCHAFT

  公开号：EP1516005A1

  公开（公告）日：2005-03-23
• Process for Producing SN-Comprising Catalysts
  申请人：BASF SE

  公开号：US20130131339A1

  公开（公告）日：2013-05-23

  The present invention relates to a process for producing a supported tin-comprising catalyst, wherein a solution (S) comprising tin nitrate and at least one complexing agent is applied to the support, where the solution (S) does not comprise any solid or has a solids content of not more than 0.5% by weight based on the total amount of dissolved components.