N-(3-phenylpropyl)-N'-(2-methylquinolin-4-yl)imidodicarbonic diamide | 1254556-37-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(3-phenylpropyl)-N'-(2-methylquinolin-4-yl)imidodicarbonic diamide
• 英文别名: 1-(2-Methylquinolin-4-yl)-3-(3-phenylpropylcarbamoyl)urea
• CAS: 1254556-37-0
• 化学式: C₂₁H₂₂N₄O₂
• 分子量: 362.431
• InChiKey: QTRNAZKCNMYFFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  83.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氨基喹哪啶 、 phenyl[(3-phenylpropyl)aminocarbonyl]carbamate 在 potassium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以15%的产率得到N-(3-phenylpropyl)-N'-(2-methylquinolin-4-yl)imidodicarbonic diamide
  参考文献：
  名称：

  Synthesis and cytotoxicity of some biurets against human breast cancer T47D cell line

  摘要：

  Design, synthesis and cytotoxicity of several known and novel biurets against human breast cancer T47D cell line in comparison to doxorubicin are described. Biurets incorporating 2-methyl quinoline-4-yl and benzo[d]thiazol-2-ylthio moieties showed higher cytotoxicity and decreased cell viability in a concentration- and time-dependent manner. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.07.137

文献信息

• Synthesis and cytotoxicity of some biurets against human breast cancer T47D cell line
  作者：Shamileh Fouladdel、Ali Khalaj、Neda Adibpour、Ebrahim Azizi

  DOI：10.1016/j.bmcl.2010.07.137

  日期：2010.10

  Design, synthesis and cytotoxicity of several known and novel biurets against human breast cancer T47D cell line in comparison to doxorubicin are described. Biurets incorporating 2-methyl quinoline-4-yl and benzo[d]thiazol-2-ylthio moieties showed higher cytotoxicity and decreased cell viability in a concentration- and time-dependent manner. (C) 2010 Elsevier Ltd. All rights reserved.