6-methylluteolin | 79339-18-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 6-methylluteolin
• 英文别名: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methylchromen-4-one
• CAS: 79339-18-7
• 化学式: C₁₆H₁₂O₆
• 分子量: 300.268
• InChiKey: VSHICDFQSGJNPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-氯-3-甲基-1-丁炔 、 6-methylluteolin 在 potassium carbonate 、 potassium iodide 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以0.1 g的产率得到desmodol
  参考文献：
  名称：

  Islam, Azizul; Krishnamurti, M., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 7, p. 624 - 625

  摘要：

  DOI：
• 作为产物：
  描述：

  1-<2,4,6-Tris(3,4-dimethoxybenzyloxy)-3-methylphenyl>ethanone 在 吡啶 、 氢氧化钾 、 吡啶溴化氢盐 、 sodium carbonate 作用下， 反应 5.58h， 生成 6-methylluteolin
  参考文献：
  名称：

  Islam, Azizul; Krishnamurti, M., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 7, p. 624 - 625

  摘要：

  DOI：

文献信息

• Antihelminthic anthraquinones and method of use thereof
  申请人：Board of Trustees of MICHIGAN STATE UNIVERSITY

  公开号：US20030229032A1

  公开（公告）日：2003-12-11

  Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: 1 wherein R 1 , R 2 , R 3 , and R 4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.

  所述蒽醌类化合物具有抗蠕虫作用，尤其适用于体外或体内抑制血吸虫的组合物。优选的蒽醌类化合物具有以下式子： 1 其中 R 1 , R 2 , R 3 和 R 4 各自为氢、羟基、卤素、烷基、取代烷基、烯烃、取代烯烃、炔烃、芳基、取代芳基、环状、取代环状、酸性基团、碳水化合物或它们的组合，R 是含有 1 至 12 个碳原子的基团，如甲基、烷基、取代烷基、醛基、羟基、羟甲基、酸性基团、碳水化合物或它们的组合，卤素是 I、F、Br 或 Cl。
• Bannerjee; Seshadri, Journal Of Scientific and Industrial Research, 1954, vol. 13 B, p. 598,601
  作者：Bannerjee、Seshadri

  DOI：——

  日期：——
• Inhibitors and Enhancers of Uridine Diphosphate-Glucuronosyltransferase 2B (UGT2B)
  申请人：Oliver Yoa-Pu Hu

  公开号：US20090074708A1

  公开（公告）日：2009-03-19

  A UGT2B inhibitor capable of increasing the bio-availability of a drug, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: capillarisin, isorhamnetin, β-naphthoflavone, α-naphthoflavone, hesperetin, terpineol, (+)-limonene, β-myrcene, swertiamarin, eriodictyol, cineole, apigenin, baicalin, ursolic acid, isovitexin, lauryl alcohol, puerarin, trans-cinnamaldehyde, 3-phenylpropyl acetate, isoliquritigenin, paeoniflorin, gallic acid, genistein, glycyrrhizin, protocatechuic acid, ethyl myristate, umbelliferone, PEG (Polyethylene glycol) 400, PEG 2000, PEG 4000, Tween 20, Tween 60, Tween 80, BRIJ® 58, BRIJ® 76, Pluronic® F68, Pluronic® F127, and a combination thereof. A UGT2B enhancer capable of enhancing a clearance rate of morphine-like analgesic agents, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: nordihydroguaiaretic acid, wogonin, trans-cinnamic acid, baicalein, quercetin, daidzein, oleanolic acid, homoorientin, hesperetin, narigin, neohesperidin, (+)-epicatechin, hesperidin, liquiritin, eriodictyol, formononetin, quercitrin, genkwanin, kaempferol, isoquercitrin, (+)-catechin, naringenin, daidzin, (−)-epicatechin, luteolin-7-glucoside, ergosterol, rutin, luteolin, ethyl myristate, apigenin, 3-phenylpropyl acetate, umbelliferone, glycyrrhizin, protocatechuic acid, poncirin, isovitexin, 6-gingerol, cineole, genistein, trans-cinnamaldehyde, and a combination thereof.
• US20140271944A1
  申请人：——

  公开号：US20140271944A1

  公开（公告）日：2014-09-18
• Compositions for Alleviating Inflammation and Oxidative Stress in a Mammal
  申请人：Lifeline Nutraceuticals

  公开号：US20150283193A9

  公开（公告）日：2015-10-08

  An antioxidant-promoting composition that increases antioxidant defense potential in a subject is disclosed. The composition contains Bacopa monniera extract comprising a Bacopa monniera active ingredient; a Silybum marianum (milk thistle) extract comprising a Silybum marianum active ingredient; a Withania somnifera (ashwagandha) extract comprising a Withania somnifera active ingredient; a Camellia sinensis (green tea) extract comprising a Camellia sinensis active ingredient; a Curcuma longa (turmeric) extract comprising at least one Curcuma longa active ingredient, and optionally a Centella asiatica (Gotu kola) extract; a Ginko biloba extract; an Aloe vera extract; and N-acetyl cysteine. The process for quantifying Nrf2 transcription factor activating potential of the botanical extracts comprising the botanical active ingredients is described.