(3S,5R)-3,5-bis(methoxymethoxy)-2-methylcyclohex-1-enecarbaldehyde | 1259529-37-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3S,5R)-3,5-bis(methoxymethoxy)-2-methylcyclohex-1-enecarbaldehyde
• 英文别名: (3S,5R)-3,5-bis(methoxymethoxy)-2-methylcyclohexene-1-carbaldehyde
• CAS: 1259529-37-7
• 化学式: C₁₂H₂₀O₅
• 分子量: 244.288
• InChiKey: RGQPZJRXNHRBRR-NEPJUHHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  ((3S,5R)-3,5-bis(methoxymethoxy)-2-methylenecyclohexyl)methanol 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 (3S,5R)-3,5-bis(methoxymethoxy)-2-methylcyclohex-1-enecarbaldehyde
  参考文献：
  名称：

  Enantioselective Synthesis of A Key A-Ring Intermediate for the Preparation of 1α,25-Dihydroxyvitamin D₃

  摘要：

  A novel approach to the key A-ring alpha, beta-unsaturated aldehyde 1, an important intermediate for the preparation of 1 alpha,25-dihydroxyvitamin D-3, has been developed. The strategy started from the inexpensive starting material (R)-carvone with an ene reaction serving as the key step toward the potential synthesis of vitamin D-3 analogues bearing the modification at the C-2 position.

  DOI：

  10.1021/ol102586w

文献信息

• Enantioselective Synthesis of A Key A-Ring Intermediate for the Preparation of 1α,25-Dihydroxyvitamin D₃
  作者：Yan Chen、Tong Ju

  DOI：10.1021/ol102586w

  日期：2011.1.7

  A novel approach to the key A-ring alpha, beta-unsaturated aldehyde 1, an important intermediate for the preparation of 1 alpha,25-dihydroxyvitamin D-3, has been developed. The strategy started from the inexpensive starting material (R)-carvone with an ene reaction serving as the key step toward the potential synthesis of vitamin D-3 analogues bearing the modification at the C-2 position.