2-氨基-N-异丙叉乙酰胺盐酸盐 | 92885-79-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-氨基-N-异丙叉乙酰胺盐酸盐
• 英文名称: 2-amino-N-mesitylacetamide
• 英文别名: 2-amino-N-(2,4,6-trimethylphenyl)acetamide
• CAS: 92885-79-5
• 化学式: C₁₁H₁₆N₂O
• mdl: MFCD06337045
• 分子量: 192.261
• InChiKey: XAULTICIAIZPKJ-UHFFFAOYSA-N

物化性质

• 沸点：
  329.9±30.0 °C(Predicted)
• 密度：
  1.098±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  2-氨基-N-异丙叉乙酰胺盐酸盐 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 72.0h， 以1.52 g的产率得到N-(2,4,6-trimethylphenyl)-1,2-diaminoethane
  参考文献：
  名称：

  Non covalent immobilization of pyrene-tagged ruthenium complexes onto graphene surfaces for recycling in olefin metathesis reactions

  摘要：

  Synthesis of Hoveyda-type ruthenium complexes, modified by pyrene tags on the NHC ligand and/or the benzylidene moiety, is described. Thanks to non-covalent it-err interactions these new complexes were immobilized on carbon supports [reduced graphene oxide (rGO) or graphene] and their activity and recoverability for metatheses reactions have been studied. A SIPr-based complex possessing the pyrene function on the benzylidene ligand (C2) delivered the best results for the ring closing metathesis of diethyldiallyl malonate as benchmark reaction. The presence of additional pyrene-functionalized styrenyl-ether as ligand to the rGO-supported catalyst (C2/L@rGO) noticeably improved the recycling procedure allowing supplementary efficient catalytic runs. This may be due either to a facilitated boomerang effect or to a gradual release of the active species in solution. Finally, catalyst C2/L@rGO was proven to be successfully used to promote metathesis reactions in a multisubstrate procedure, the same supported catalyst batch being successively engaged to transform three different substrates, in diene and ene-yne RCM reactions. (C) 2016 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2016.10.004
• 作为产物：
  描述：

  2,4,6-三甲基苯胺 在 N-甲基吗啉 、 盐酸 、 氯甲酸异丁酯 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 19.5h， 生成 2-氨基-N-异丙叉乙酰胺盐酸盐
  参考文献：
  名称：

  Non covalent immobilization of pyrene-tagged ruthenium complexes onto graphene surfaces for recycling in olefin metathesis reactions

  摘要：

  Synthesis of Hoveyda-type ruthenium complexes, modified by pyrene tags on the NHC ligand and/or the benzylidene moiety, is described. Thanks to non-covalent it-err interactions these new complexes were immobilized on carbon supports [reduced graphene oxide (rGO) or graphene] and their activity and recoverability for metatheses reactions have been studied. A SIPr-based complex possessing the pyrene function on the benzylidene ligand (C2) delivered the best results for the ring closing metathesis of diethyldiallyl malonate as benchmark reaction. The presence of additional pyrene-functionalized styrenyl-ether as ligand to the rGO-supported catalyst (C2/L@rGO) noticeably improved the recycling procedure allowing supplementary efficient catalytic runs. This may be due either to a facilitated boomerang effect or to a gradual release of the active species in solution. Finally, catalyst C2/L@rGO was proven to be successfully used to promote metathesis reactions in a multisubstrate procedure, the same supported catalyst batch being successively engaged to transform three different substrates, in diene and ene-yne RCM reactions. (C) 2016 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2016.10.004

文献信息

• Pro-Gly based dipeptide containing sulphonamide functionality, their antidiabetic, antioxidant, and anti-inflammatory activities. Synthesis, characterization and computational studies
  作者：Solomon Izuchi Attah、Uchechukwu Chris Okoro、Surya Pratap Singh、Cosmas Chinweike Eze、Collins Ugochukwu Ibeji、James Anayochukwu Ezugwu、Obinna Ugochukwu Okenyeka、Ogechi Ekoh、David Izuchukwu Ugwu、Florence Uchenna Eze

  DOI：10.1016/j.molstruc.2022.133280

  日期：2022.9

  properties such as antidiabetic, antioxidant, antimalarial, etc. The base promoted reactions of the L-proline with substituted benzenesulphonyl chloride gave benzenesulphonamides an excellent yield. The condensation reaction of benzenesulphonamides with the carboxamide derivatives using peptide coupling reagents gave targeted products (8a-j). The ten novel compounds were characterized using 1HNMR, 13CNMR

  如今，对降糖药、抗氧化剂和抗炎药的耐药性越来越高，这是一个复杂而严重的健康问题，因为市场上的许多药物都不再有效。选择合成新型二肽-磺酰胺杂化物是基于它们广泛的生物学特性，如抗糖尿病、抗氧化、抗疟等。碱促进了L-脯氨酸与取代的苯磺酰氯的反应，使苯磺酰胺具有优异的产率。苯磺酰胺与羧酰胺衍生物使用肽偶联试剂的缩合反应得到目标产物(8a-j)。使用1 HNMR、13CNMR、FTIR 和 MS 光谱技术。DFT 和计算机内抗糖尿病、抗氧化和抗炎研究表明，与标准药物相比，这些化合物与靶蛋白残基具有良好的相互作用，并且具有更高的对接分数。还研究了体内抗糖尿病、抗炎和体外抗氧化活性。进行了葡萄糖、胆固醇和三酰基甘油水平的估计，并观察到化合物8a表现出显着的抗糖尿病活性。化合物8b、8c和8d也具有中等的抗糖尿病活性。在体内抗炎研究中，化合物8a在给药 0.5 h 和 1 h 时分别抑制角叉菜胶引起的大鼠爪水肿
• SLOUKA, JAN;HEJSEK, MILOSLAV, ACTA UNIV. PALACK. OLOMUC. FAC. RERUM NATUR. CHEM., 91,(1988) N 27, C. 21+
  作者：SLOUKA, JAN、HEJSEK, MILOSLAV

  DOI：——

  日期：——
• Chemical Inhibitors of Inhibitors of Differentiation
  申请人：CHAUDHARY Jaideep

  公开号：US20090226422A1

  公开（公告）日：2009-09-10

  The present invention provides identification of inhibitors of inhibitors of differentiation (Id) for use in the treatment and prevention of diseases in mammals. The inhibitors of Id are effective alone in the treatment of a variety of cellular proliferative disorders including, but not limited to, diseases such as cancer, arthritis, age-related macular degeneration, psoriasis, neoplasms, angiomas, endometriosis, obesity, age-related macular degeneration, retinopathies, restenosis, scaring, fibrogenesis, fibrosis, cardiac remodeling, pulmonary fibrosis, scleroderma, failure associated with myocardial infarction, keloids, fibroid tumors and stenting. Additionally, these compounds are effective in blocking angiogenesis in tumor development, inducing apoptosis in malignant cells, inhibiting proliferation of cancer cells, increasing the effectiveness of chemotherapeutic agents, regulating transcriptional activity, reducing inflammation, increasing cellular differentiation, modulating ETS domain transcription factors, modulating PAX transcription factors, modulating TCF-ETS domain transcription factors, down regulating RAF-1/MAPK, upregulating JNK signaling pathways, and modulating cellular transformation.
• Non covalent immobilization of pyrene-tagged ruthenium complexes onto graphene surfaces for recycling in olefin metathesis reactions
  作者：Houssein Nasrallah、Stéphane Germain、Pierre Queval、Caroline Bouvier、Marc Mauduit、Christophe Crévisy、Emmanuelle Schulz

  DOI：10.1016/j.molcata.2016.10.004

  日期：2016.12

  Synthesis of Hoveyda-type ruthenium complexes, modified by pyrene tags on the NHC ligand and/or the benzylidene moiety, is described. Thanks to non-covalent it-err interactions these new complexes were immobilized on carbon supports [reduced graphene oxide (rGO) or graphene] and their activity and recoverability for metatheses reactions have been studied. A SIPr-based complex possessing the pyrene function on the benzylidene ligand (C2) delivered the best results for the ring closing metathesis of diethyldiallyl malonate as benchmark reaction. The presence of additional pyrene-functionalized styrenyl-ether as ligand to the rGO-supported catalyst (C2/L@rGO) noticeably improved the recycling procedure allowing supplementary efficient catalytic runs. This may be due either to a facilitated boomerang effect or to a gradual release of the active species in solution. Finally, catalyst C2/L@rGO was proven to be successfully used to promote metathesis reactions in a multisubstrate procedure, the same supported catalyst batch being successively engaged to transform three different substrates, in diene and ene-yne RCM reactions. (C) 2016 Elsevier B.V. All rights reserved.