1-[2,4,6-trihydroxy-3-chlorobenzene]butan-1-one | 1245818-23-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[2,4,6-trihydroxy-3-chlorobenzene]butan-1-one
• 英文别名: 1-(3-chloro-2,4,6-trihydroxyphenyl)butan-1-one
• CAS: 1245818-23-8
• 化学式: C₁₀H₁₁ClO₄
• 分子量: 230.648
• InChiKey: JRZAJIHXPJWKDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.44
• 重原子数：
  15.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  77.76
• 氢给体数：
  3.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1-[2,4,6-trihydroxy-3-chlorobenzene]butan-1-one 在 potassium carbonate 、 二乙胺 作用下， 以 乙醇 为溶剂， 生成 6-chloro-3-ethyl-5,7-dimethoxymethoxychroman-4-one
  参考文献：
  名称：

  Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis

  摘要：

  This article reports the rational medicinal chemistry of a natural product, agrimophol (1), as a new disruptor of intrabacterial pH (pH(IB)) homeostasis in Mycobacterium tuberculosis (Mtb). Through the systematic investigation of the structure-activity relationship of 1, scaffold-hopping of the diphenylmethane scaffold, pharmacophore displacement strategies, and studies of the structure-metabolism relationship, a new derivative 5a was achieved. Compound 5a showed 100-fold increased potency in the ability to reduce pH(IB) to pH 6.0 and similarly improved mycobactericidal activity compared with 1 against both Mycobacterium bovis-BCG and Mtb. Compound 5a possessed improved metabolic stability in human liver microsomes and hepatocytes, lower cytotoxicity, higher selectivity index, and similar pK(a) value to natural 1. This study introduces a novel scaffold to an old drug, resulting in improved mycobactericidal activity through decreasing pH(IB), and may contribute to the critical search for new agents to overcome drug resistance and persistence in the treatment of tuberculosis.

  DOI：

  10.1021/acsinfecdis.8b00325
• 作为产物：
  描述：

  1-(2,4,6-trihydroxyphenyl)butan-1-one 在 磺酰氯 作用下， 以 乙醇 、 氯仿 为溶剂， 反应 0.5h， 以95%的产率得到1-[2,4,6-trihydroxy-3-chlorobenzene]butan-1-one
  参考文献：
  名称：

  Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds

  摘要：

  We have studied the diversity of secondary metabolites of cellular slime molds to utilize them as new biological resources for natural product chemistry. From the methanol extract of fruiting bodies of Polysphondylium tenuissimum, we obtained five prenylated and geranylated aromatic compounds, Pt-1-5 (1-5). An additional aromatic compound, Ppc-1 (6), was isolated from Polysphondylium pseudo-candidum. The structures of these compounds were determined by spectral analysis, and synthetic routes to 4, 5, and 6 were developed. Compound 5 showed the glucose consumption-promotive activity on 3T3-L1 cells. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.06.029