2-[2-Ethyl-2-(2-hydroxy-ethoxymethyl)-butoxy]-ethanol | 137378-22-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[2-Ethyl-2-(2-hydroxy-ethoxymethyl)-butoxy]-ethanol
• 英文别名: 2-[2-Ethyl-2-(2-hydroxyethoxymethyl)butoxy]ethanol
• CAS: 137378-22-4
• 化学式: C₁₁H₂₄O₄
• 分子量: 220.309
• InChiKey: XROPUKZKNYXJNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[2-Ethyl-2-(2-hydroxy-ethoxymethyl)-butoxy]-ethanol 在 吡啶 、 cesium fluoride 作用下， 以 乙腈 为溶剂， 反应 2.0h， 生成 10,10-Diethyl-6,7,10,11,13,14-hexahydro-9H-5,8,12,15-tetraoxa-benzocyclotridecene
  参考文献：
  名称：

  Czech, Bronislaw P.; Zazulak, Wolodymyr; Kumar, Anand, Journal of Heterocyclic Chemistry, 1991, vol. 28, # 5, p. 1387 - 1394

  摘要：

  DOI：
• 作为产物：
  描述：

  丙二醇乙醚 在 lithium aluminium tetrahydride 、 potassium tert-butylate 、 叔丁醇 作用下， 以 乙醚 为溶剂， 反应 2.0h， 生成 2-[2-Ethyl-2-(2-hydroxy-ethoxymethyl)-butoxy]-ethanol
  参考文献：
  名称：

  Czech, Bronislaw P.; Zazulak, Wolodymyr; Kumar, Anand, Journal of Heterocyclic Chemistry, 1991, vol. 28, # 5, p. 1387 - 1394

  摘要：

  DOI：

文献信息

• US9018323B2
  申请人：——

  公开号：US9018323B2

  公开（公告）日：2015-04-28
• Czech, Bronislaw P.; Zazulak, Wolodymyr; Kumar, Anand, Journal of Heterocyclic Chemistry, 1991, vol. 28, # 5, p. 1387 - 1394
  作者：Czech, Bronislaw P.、Zazulak, Wolodymyr、Kumar, Anand、Dalley, N. Kent、Weiming, Jiang、Bartsch, Richard A.

  DOI：——

  日期：——
• Design and synthesis of highly selective ionophores for lithium ion based on 14-crown-4 derivatives for an ion-selective electrode
  作者：Koji. Suzuki、Hiroyuki. Yamada、Kazunari. Sato、Kazuhiko. Watanabe、Hideaki. Hisamoto、Yoshito. Tobe、Kazuya. Kobiro

  DOI：10.1021/ac00071a012

  日期：1993.12.1

  Highly Li+-selective ionophores based on 14-crown-4 derivatives were designed and synthesized, and the relationship of their molecular structures and ion selectivities was investigated in order to obtain a highly Li+-selective electrode. The ion selectivities were examined with 11 kinds of 14-crown-4 derivatives, which were prepared according to the proposed two types of Li+ ionophore models. Excellent Li+-selective ionophores were obtained by introducing a bulky ''block'' subunit into the ethano-bridge section of the base crown ring, which effectively prevents the formation of a 2:1 or 3:1 sandwich-type complex consisting of the crown ether and cations larger than Li+. The best Li+/Na+ selectivity (more than 1000) was obtained for the electrode using the 14-crown-4 derivative with a bulky decalin subunit. These results offer the general ion selectivity features of 14-crown-4-based compounds.