[(1,3-diphenylpyrazol-4-yl)methylene](o-tolyl)amine | 144119-18-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [(1,3-diphenylpyrazol-4-yl)methylene](o-tolyl)amine
• 英文别名: 1-(1,3-diphenylpyrazol-4-yl)-N-(2-methylphenyl)methanimine
• CAS: 144119-18-6
• 化学式: C₂₃H₁₉N₃
• 分子量: 337.424
• InChiKey: GYWNQYLSZDKBME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  benzohydroximoyl chloride 、 [(1,3-diphenylpyrazol-4-yl)methylene](o-tolyl)amine 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 12.0h， 以10%的产率得到5-(1,3-Diphenyl-1H-pyrazol-4-yl)-3-phenyl-4-o-tolyl-4,5-dihydro-[1,2,4]oxadiazole
  参考文献：
  名称：

  Chary, T Jagan Mohana; Reddy, Ch V Narsimha; Murthy, A Krishna, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1992, vol. 31, # 8, p. 495 - 498

  摘要：

  DOI：
• 作为产物：
  描述：

  1-苯基-2-(1-苯基亚乙基)肼 在 溶剂黄146 、 三氯氧磷 作用下， 以 甲醇 为溶剂， 反应 12.0h， 生成 [(1,3-diphenylpyrazol-4-yl)methylene](o-tolyl)amine
  参考文献：
  名称：

  1,3-Diphenylpyrazoles: synthesis and antiparasitic activities of azomethine derivatives

  摘要：

  1,3-Diphenylpyrazole-4-carboxaldehyde and 1-(4-nitrophenyl)-3-phenylpyrazole-4-carboxaldehyde were obtained from the appropriated phenylhydrazones via the Vilsmeier-Haack reaction. These two aldehydes were functionalized by various substituted anilines or substituted benzylamines. Antiparasitic activities of the corresponding azomethines were assessed. In the most cases, nitrated compounds were found to be more efficient than non-nitrated ones against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(02)01388-0

文献信息

• 1,3-Diphenylpyrazoles: synthesis and antiparasitic activities of azomethine derivatives
  作者：Pascal Rathelot、Nadine Azas、Hussein El-Kashef、Florence Delmas、Carole Di Giorgio、Pierre Timon-David、José Maldonado、Patrice Vanelle

  DOI：10.1016/s0223-5234(02)01388-0

  日期：2002.8

  1,3-Diphenylpyrazole-4-carboxaldehyde and 1-(4-nitrophenyl)-3-phenylpyrazole-4-carboxaldehyde were obtained from the appropriated phenylhydrazones via the Vilsmeier-Haack reaction. These two aldehydes were functionalized by various substituted anilines or substituted benzylamines. Antiparasitic activities of the corresponding azomethines were assessed. In the most cases, nitrated compounds were found to be more efficient than non-nitrated ones against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.
• Chary, T Jagan Mohana; Reddy, Ch V Narsimha; Murthy, A Krishna, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1992, vol. 31, # 8, p. 495 - 498
  作者：Chary, T Jagan Mohana、Reddy, Ch V Narsimha、Murthy, A Krishna

  DOI：——

  日期：——