1-(4-bromophenyl)-2-(2,4-dichlorophenyl)-5-ethyl-N'-pivaloyl-1H-imidazole-4-carbohydrazide | 1120371-49-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(4-bromophenyl)-2-(2,4-dichlorophenyl)-5-ethyl-N'-pivaloyl-1H-imidazole-4-carbohydrazide
• CAS: 1120371-49-4
• 化学式: C₂₃H₂₃BrCl₂N₄O₂
• 分子量: 538.271
• InChiKey: SSUYRDIDVRCYDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.98
• 重原子数：
  32.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  76.02
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1-(4-bromophenyl)-2-(2,4-dichlorophenyl)-5-ethyl-N'-pivaloyl-1H-imidazole-4-carbohydrazide 在 伯吉斯试剂 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以49%的产率得到2-(1-(4-bromophenyl)-2-(2,4-dichlorophenyl)-5-ethyl-1H-imidazol-4-yl)-5-t-butyl-1,3,4-oxadiazole
  参考文献：
  名称：

  Diarylimidazolyl oxadiazole and thiadiazole derivatives as cannabinoid CB1 receptor antagonists

  摘要：

  Since the CB1 receptor antagonist SR141716 (rimonabant) was reported to modulate food intake, CB1 antagonism has been considered as a new therapeutic target in the treatment of obesity. Several series of derivatives based on diarylimidazolyl oxadiazole and thiadiazole scaffolds were synthesized and tested for CB1 receptor binding affinity. SAR studies directed toward the optimization of imidazole scaffolds resulted in the discovery of 10s which showed highest potency for CB1 receptor binding affinity (IC50 = 1.91 nM) prepared to date. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.130
• 作为产物：
  描述：

  2,2-二甲基丙酰肼 、 1-(4-溴苯基)-2-(2,4-二氯苯基)-5-乙基-1H-咪唑-4-羧酸 在 N-甲基吗啉 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以69%的产率得到1-(4-bromophenyl)-2-(2,4-dichlorophenyl)-5-ethyl-N'-pivaloyl-1H-imidazole-4-carbohydrazide
  参考文献：
  名称：

  Diarylimidazolyl oxadiazole and thiadiazole derivatives as cannabinoid CB1 receptor antagonists

  摘要：

  Since the CB1 receptor antagonist SR141716 (rimonabant) was reported to modulate food intake, CB1 antagonism has been considered as a new therapeutic target in the treatment of obesity. Several series of derivatives based on diarylimidazolyl oxadiazole and thiadiazole scaffolds were synthesized and tested for CB1 receptor binding affinity. SAR studies directed toward the optimization of imidazole scaffolds resulted in the discovery of 10s which showed highest potency for CB1 receptor binding affinity (IC50 = 1.91 nM) prepared to date. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.130