6,6-dimethoxy-2-methylene-hexanoic acid methyl ester | 940279-10-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6,6-dimethoxy-2-methylene-hexanoic acid methyl ester
• 英文别名: Methyl 6,6-dimethoxy-2-methylidenehexanoate；methyl 6,6-dimethoxy-2-methylidenehexanoate
• CAS: 940279-10-7
• 化学式: C₁₀H₁₈O₄
• 分子量: 202.251
• InChiKey: SQTGLGSYTWVQND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6,6-dimethoxy-2-methylene-hexanoic acid methyl ester 在 盐酸 、 溶剂黄146 作用下， 反应 2.0h， 以100%的产率得到5-Carbomethoxyhex-5-ene-1-al
  参考文献：
  名称：

  Highly Diastereoselective Synthesis of vicinal Quaternary and Tertiary Stereocenters Using the Iodo-aldol Cyclization

  摘要：

  The intramolecular iodo-aldol cyclization of alpha-substituted enoate aldehydes and ketones is described. Using prochiral starting materials, the reaction produces hetero- and carbocycles containing quaternary centers adjacent to secondary or tertiary centers. The reactions occur in good yields and are highly selective for the trans-products, having the hydroxyl and iodomethyl groups on opposite faces of the ring system.

  DOI：

  10.1021/ol070482k
• 作为产物：
  描述：

  6,6-dimethoxy-2-methylene-hexanal 在 sodium chlorite 、 sodium dihydrogenphosphate 、 2-甲基-2-丁烯 、 potassium carbonate 作用下， 以 水 、 丙酮 、 叔丁醇 为溶剂， 反应 2.5h， 生成 6,6-dimethoxy-2-methylene-hexanoic acid methyl ester
  参考文献：
  名称：

  Highly Diastereoselective Synthesis of vicinal Quaternary and Tertiary Stereocenters Using the Iodo-aldol Cyclization

  摘要：

  The intramolecular iodo-aldol cyclization of alpha-substituted enoate aldehydes and ketones is described. Using prochiral starting materials, the reaction produces hetero- and carbocycles containing quaternary centers adjacent to secondary or tertiary centers. The reactions occur in good yields and are highly selective for the trans-products, having the hydroxyl and iodomethyl groups on opposite faces of the ring system.

  DOI：

  10.1021/ol070482k

文献信息

• CURABLE COMPOSITIONS, SEALING MATERIAL, AND ADHESIVE
  申请人：SEKISUI CHEMICAL CO., LTD.

  公开号：EP1457527A1

  公开（公告）日：2004-09-15

  Curable compositions capable of giving a cured article excellent in weatherability and flam retardancy. (1) One of the curable compositions comprises an organic polymer having at least one crosslinkable hydrolysable silyl group and phyllosilicate. It has enhanced weatherability due to incorporation of the phyllosilicate, and has further enhanced weatherability because the bleeding of an ultraviolet absober and a light stabilizer is inhibited. (2) The other composition comprises 100parts by weight of a urethane resin, epoxy resin, and/or modified polysulfide resin and 0.1 to 100 parts of weight of a phyllosilicate. It has enhanced weatherability due to incorporation of phyllosilicate, and has further enhanced weatherability because the bleeding of an ultraviolet absorber and a light stabilizer is inhibited.

  能使固化物具有优异耐候性和阻燃性的可固化组合物。(1) 其中一种可固化组合物由至少具有一个可交联水解硅基的有机聚合物和植硅酸盐组成。由于掺入了植硅体，它的耐候性得到了提高，而且由于抑制了紫外线吸收剂和光稳定剂的渗出，它的耐候性得到了进一步提高。(2) 另一种组合物由 100 重量份的聚氨酯树脂、环氧树脂和/或改性聚硫树脂和 0.1 至 100 重量份的植硅体组成。由于加入了植物硅酸盐，其耐候性得到了提高，而且由于紫外线吸收剂和光稳定剂的渗出受到抑制，其耐候性得到了进一步提高。
• Curable compositions, sealing material, and adhesive
  申请人：Bandou Akihiko

  公开号：US20050261412A1

  公开（公告）日：2005-11-24

  Curable compositions capable of giving a cured article excellent in weatherability and flam retardancy. (1) One of the curable compositions comprises an organic polymer having at least one crosslinkable hydrolysable silyl group and phyllosilicate. It has enhanced weatherability due to incorporation of the phyllosilicate, and has further enhanced weatherability because the bleeding of an ultraviolet absober and a light stabilizer is inhibited. (2) The other composition comprises 100 parts by weight of a urethane resin, epoxy resin, and/or modified polysulfide resin and 0.1 to 100 parts of weight of a phyllosilicate. It has enhanced weatherability due to incorporation of phyllosilicate, and has further enhanced weatherability because the bleeding of an ultraviolet absorber and a light stabilizer is inhibited.

  能使固化物具有优异耐候性和阻燃性的可固化组合物。(1) 其中一种可固化组合物由至少具有一个可交联水解硅基的有机聚合物和植硅酸盐组成。由于掺入了植硅体，它的耐候性得到了提高，而且由于抑制了紫外线吸收剂和光稳定剂的渗出，它的耐候性得到了进一步提高。(2) 另一种组合物由 100 重量份的聚氨酯树脂、环氧树脂和/或改性聚硫树脂和 0.1 至 100 重量份的植硅体组成。由于加入了植物硅酸盐，其耐候性得到了提高，而且由于抑制了紫外线吸收剂和光稳定剂的渗出，其耐候性得到了进一步提高。
• CURABLE COMPOSITION, SEALING MATERIAL, AND ADHESIVE
  申请人：SEKISUI CHEMICAL CO., LTD.

  公开号：EP1457527B1

  公开（公告）日：2013-03-27
• US7135518B2
  申请人：——

  公开号：US7135518B2

  公开（公告）日：2006-11-14
• Highly Diastereoselective Synthesis of <i>vicinal</i> Quaternary and Tertiary Stereocenters Using the Iodo-aldol Cyclization
  作者：Frederic Douelle、Amy S. Capes、Michael F. Greaney

  DOI：10.1021/ol070482k

  日期：2007.5.1

  The intramolecular iodo-aldol cyclization of alpha-substituted enoate aldehydes and ketones is described. Using prochiral starting materials, the reaction produces hetero- and carbocycles containing quaternary centers adjacent to secondary or tertiary centers. The reactions occur in good yields and are highly selective for the trans-products, having the hydroxyl and iodomethyl groups on opposite faces of the ring system.