2-(2-Aminopyrimidin-4-yl)-4-bromophenol | 925003-46-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(2-Aminopyrimidin-4-yl)-4-bromophenol
• 英文别名: 2-(2-aminopyrimidin-4-yl)-4-bromophenol
• CAS: 925003-46-9
• 化学式: C₁₀H₈BrN₃O
• 分子量: 266.097
• InChiKey: ZIXNNXPMCCNPCF-UHFFFAOYSA-N

物化性质

• 沸点：
  465.6±53.0 °C(Predicted)
• 密度：
  1.683±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-allyl-2-methoxyphenylboronic acid 、 2-(2-Aminopyrimidin-4-yl)-4-bromophenol 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 乙二醇二甲醚 、 水 为溶剂， 反应 16.67h， 以72%的产率得到5'-allyl-3-(2-aminopyrimidin-4-yl)-2'-methoxy-[1,1'-biphenyl]-4-ol
  参考文献：
  名称：

  Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity

  摘要：

  A versatile synthetic route is reported towards the preparation of new analogues for potent neurotrophic agent biaryl-type lignan honokiol. A focused 24-membered library of derivatives containing five different groups at 5'-position of honokiol has been prepared in fair to good overall yields. Compared to the natural product, or to analogues with a short alkyl chain in this position, these new derivatives have lost most of the neurotrophic activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.12.015
• 作为产物：
  描述：

  1-(5-Bromo-2-methoxyphenyl)prop-2-yn-1-ol 在 Jones reagent 、 三氟二甲基硫醚络合物 、 sodium carbonate 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 、 丙酮 、 乙腈 为溶剂， 反应 8.5h， 生成 2-(2-Aminopyrimidin-4-yl)-4-bromophenol
  参考文献：
  名称：

  Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity

  摘要：

  A versatile synthetic route is reported towards the preparation of new analogues for potent neurotrophic agent biaryl-type lignan honokiol. A focused 24-membered library of derivatives containing five different groups at 5'-position of honokiol has been prepared in fair to good overall yields. Compared to the natural product, or to analogues with a short alkyl chain in this position, these new derivatives have lost most of the neurotrophic activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.12.015

文献信息

• Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity
  作者：Vemula Praveen Kumar、R. Gajendra Reddy、Duc Duy Vo、Sumana Chakravarty、Srivari Chandrasekhar、René Grée

  DOI：10.1016/j.bmcl.2011.12.015

  日期：2012.2

  A versatile synthetic route is reported towards the preparation of new analogues for potent neurotrophic agent biaryl-type lignan honokiol. A focused 24-membered library of derivatives containing five different groups at 5'-position of honokiol has been prepared in fair to good overall yields. Compared to the natural product, or to analogues with a short alkyl chain in this position, these new derivatives have lost most of the neurotrophic activity. (C) 2011 Elsevier Ltd. All rights reserved.