5,5'-methylenebis(1,3-dimethyluracil) | 10320-84-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5,5'-methylenebis(1,3-dimethyluracil)
• 英文别名: 5-[(1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione；5-[(1,3-dimethyl-2,4-dioxopyrimidin-5-yl)methyl]-1,3-dimethylpyrimidine-2,4-dione
• CAS: 10320-84-0
• 化学式: C₁₃H₁₆N₄O₄
• mdl: MFCD09376385
• 分子量: 292.294
• InChiKey: PWNPYFFECLSIFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.384
• 拓扑面积：
  81.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  腺嘌呤 生成 5,5'-methylenebis(1,3-dimethyluracil)
  参考文献：
  名称：

  ITAHARA, TOSHIO, CHEM. LETT.,(1990) N, C. 1105-1106

  摘要：

  DOI：

文献信息

• Reductive debromination and coupling reaction in the thermolysis of 5-bromouracils in N,N-dialkylamides. Cleavage of the C(5)–bromine bond by an initial electron-transfer process
  作者：Magiochi Sako、Mikio Suzuki、Miyuki Tanabe、Yoshifumi Maki

  DOI：10.1039/p19810003114

  日期：——

  Thermolysis of various 5-bromouracils (1) in N,N-dialkylamides results in the formation of methylenebisuracils (2) and reductive debrominated products (3)via cleavage of the C(5)–Br bond; the latter involves a one-electron transfer process. The product distribution between (2) and (3) depends upon the nature of substituents in the uracil ring.

  N，N-二烷基酰胺中的各种5-溴尿嘧啶（1）的热解通过C（5）-Br键的裂解形成亚甲基双尿嘧啶（2）和还原性溴化产物（3）；后者涉及单电子转移过程。（2）和（3）之间的产物分布取决于尿嘧啶环中取代基的性质。
• Coupling of 1,3-Dimethylthymine and Adenine with Sodium Peroxodisulfate
  作者：Toshio Itahara

  DOI：10.1246/cl.1990.1105

  日期：1990.7

  Heating of a solution of 1,3-dimethylthymine and adenine in water containing sodium peroxodisulfate at 80 °C resulted in the formation of their coupling products.

  将 1,3-二甲基胸腺嘧啶和腺嘌呤在含有过二硫酸钠的水中的溶液在 80 °C 下加热，会生成它们的偶联产物。
• A simple synthesis of di(uracilyl)aryl methanes and 1,ω-bis[di(uracilyl)methyl]benzenes
  作者：Subodh Kumar、Vaishalli Malik、Navneet Kaur、Kuljit Kaur

  DOI：10.1016/j.tetlet.2006.09.158

  日期：2006.11

  Di(uracilyl)aryl methanes and their homologues, 1, omega-bis[di(uracilyl) methyl]benzenes, have been synthesized in good yields through the HBr-acetic acid catalyzed condensation of 1-alkyl-/1,3-dialkyluracil derivatives with readily available aryl aldehydes and dialdehydes. (c) 2006 Elsevier Ltd. All rights reserved.
• ITAHARA, TOSHIO, CHEM. LETT.,(1990) N, C. 1105-1106
  作者：ITAHARA, TOSHIO

  DOI：——

  日期：——
• SAKO, MAGIOCHI;SUZUKI, MIKIO;TANABE, MIYUKI;MAKI, YOSHIFUMI, J. CHEM. SOC. PERKIN TRANS., 1981, N 12, 3114-3117
  作者：SAKO, MAGIOCHI、SUZUKI, MIKIO、TANABE, MIYUKI、MAKI, YOSHIFUMI

  DOI：——

  日期：——