(4-氯-喹啉-7-基)-二甲基-胺 | 178984-46-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: (4-氯-喹啉-7-基)-二甲基-胺
• 中文别名: 4-氯-7-二甲氨基-喹啉
• 英文名称: 4-chloro-N,N-dimethylquinolin-7-amine
• 英文别名: 4-Chloro-7-N,N-dimethylaminoquinoline；4-chloro-7-dimethylaminoquinoline
• CAS: 178984-46-8
• 化学式: C₁₁H₁₁ClN₂
• 分子量: 206.675
• InChiKey: RSILXKGPRQLNLJ-UHFFFAOYSA-N

物化性质

• 沸点：
  332.7±27.0 °C(Predicted)
• 密度：
  1.239±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4-氯-喹啉-7-基)-二甲基-胺 、 4-{4-[(4-aminoanilino)carbonyl]anilino}-1-methylpyridinium chloride 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 96.0h， 以27%的产率得到7-(dimethylamino)-4-[4-({4-[(1-methyl-4-pyridiniumyl)amino]benzoyl}amino)aniline]quinolinium dichloride
  参考文献：
  名称：

  WO2008/46085

  摘要：

  公开号：

文献信息

• [EN] ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS<br/>[FR] DÉRIVÉS D'AMINE ARYL-BIPYRIDINE UTILISÉS EN TANT QU'INHIBITEURS DE LA PHOSPHATIDYLINOSITOL PHOSPHATE KINASE
  申请人：PETRA PHARMA CORP

  公开号：WO2019126733A1

  公开（公告）日：2019-06-27

  The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula (I): wherein A, X, Y, Z, Q, R1, R2, R3, R4, R5, and n are described herein.

  这项发明涉及PI5P4K抑制剂，用于治疗癌症、神经退行性疾病、炎症性疾病和代谢性疾病，其化学式为（I）：其中A、X、Y、Z、Q、R1、R2、R3、R4、R5和n如本文所述。
• BHQ-CAGED NUCLEOTIDE PROBES PHOTOLYSABLE BY TWO-PHOTON EXCITATION
  申请人：Dore Timothy M.

  公开号：US20100048502A1

  公开（公告）日：2010-02-25

  The disclosure encompasses caged compounds such as caged nucleoside phosphoesters (caged nucleotides). In an embodiment, the caged nucleotides include compounds corresponding to those described by formula (I) that may be activated by two-photon excitation, and methods of synthesis of such compounds. 8-Bromo-7-hydroxyquinoline-caged ATP was synthesized and examined for its photochemistry as a biologically useful, temporally and spatially controlled ATP-releasing reagent. The combination of two-photon excitation hydrolysis and activation of caged ATP enables methods for finely focusing ATP activation at the sub-cellular level or to a greater depth of activation, thereby providing improved resolution of ATP-dependent processes at the cellular level.

  该披露涵盖了笼状化合物，例如笼状核苷酸磷酸酯（笼状核苷酸）。在一种实施方案中，笼状核苷酸包括与公式（I）描述的化合物相对应的化合物，可以通过双光子激发激活，并提供了这种化合物的合成方法。合成了8-溴-7-羟基喹啉笼状ATP，并对其光化学性质进行了检查，作为一种生物学上有用的、时间和空间可控的ATP释放试剂。双光子激发水解和笼状ATP的激活相结合，可以在亚细胞水平或更深的激活深度上精细地聚焦ATP的激活，从而提供了更好的细胞水平上ATP依赖过程的分辨率。
• QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION
  申请人：Phiasivongsa Pasit

  公开号：US20090285772A1

  公开（公告）日：2009-11-19

  Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders.

  提供了喹啉衍生物，特别是4-苯胺基喹啉衍生物。这样的喹啉衍生物可用于调节DNA甲基化，例如通过选择性抑制DNA甲基转移酶DNMT1，有效抑制C-5位置的胞嘧啶甲基化。提供了合成多种4-苯胺基喹啉衍生物和调节DNA甲基化的方法。还提供了制剂和给药这些化合物或组合物以治疗癌症和血液疾病的方法。
• Quinoline derivatives for modulating DNA methylation
  申请人：SuperGen, Inc.

  公开号：US07790746B2

  公开（公告）日：2010-09-07

  Quinoline derivatives, particularly 4-anilinoquinoline derivatives of formula (I), are provided: Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT 1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders.

  提供了喹啉衍生物，特别是公式（I）的4-苯胺基喹啉衍生物：这样的喹啉衍生物可用于调节DNA甲基化，例如通过选择性抑制DNA甲基转移酶DNMT1，有效抑制C-5位点的胞嘧啶甲基化。提供了合成多种4-苯胺基喹啉衍生物和调节DNA甲基化的方法。还提供了制剂和给药这些化合物或组合物以治疗癌症和血液系统疾病的方法。
• THIOQUINOLONE DERIVATIVE
  申请人：ZENYAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0786454A1

  公开（公告）日：1997-07-30

  Disclosed is a thioquinolone derivative which exhibits highly selective antibacterial activity against Helicobacter pylori and which is represented by the formula I wherein R1 and R2 respectively represent hydrogen atom or R1 and R2 are joined to form ―O―(CH2)2-; R3 represents halogen atom, C1-C12 alkyl group, C1-C12 alkoxy group, lower alkylsulfonyloxy group, carboxy lower alkoxy group, lower alkylthio group, benzyloxy group, benzylthio group, phenoxy group, styryl group, nitro group, phenyl group, naphthyl group, piperazinyl group, morpholino group or hydroxyl group or represents ―CH2R5, ―COR6 or ―NR7R8 wherein R5 represents benzyl group, phenyl group, hydroxyl group, lower alkoxy group, lower alkylcarbonyloxy group, phenoxy group, di-lower alkylamino group or benzimidazolylthio group, R6 represents lower alkyl group or amino group and R7 and R8 respectively represent lower alkyl group; and R4 represents hydrogen atom or lower alkyl group or is coupled with R3 to form cyclohexene ring, benzene ring or pyridine ring, R3 being not halogen atom at any of positions 5 to 8, methyl group at position 6 or methoxy group at position 6 of the quinoline ring when R1, R2 and R4 are respectively hydrogen atom, R3 and R4 being not at positions 6 and 7 or positions 6 and 8 of the quinoline ring when R1 and R2 are respectively hydrogen atom and R4 is lower alkyl group.

  本发明公开了一种硫代喹啉酮衍生物，它对幽门螺旋杆菌具有高选择性抗菌活性，由式 I 表示 其中 R1 和 R2 分别代表氢原子或 R1 和 R2 连接形成-O-(CH2)2-； R3代表卤素原子、C1-C12烷基、C1-C12烷氧基、低级烷基磺酰氧基、低级烷氧基羧基、低级烷硫基、苄氧基、苄硫基、苯氧基、苯乙烯基、硝基、苯基、萘基、哌嗪基、吗啉基或羟基或代表-CH2R5、-其中 R5 代表苄基、苯基、羟基、低级烷氧基、低级烷基羰氧基、苯氧基、二低级烷基氨基或苯并咪唑硫基，R6 代表低级烷基或氨基，R7 和 R8 分别代表低级烷基；和 R4 代表氢原子或低级烷基，或与 R3 结合形成环己烯环、苯环或吡啶环、 当 R1、R2 和 R4 分别为氢原子时，R3 不是喹啉环 5 至 8 位上的卤素原子、6 位上的甲基或 6 位上的甲氧基、 当 R1 和 R2 分别为氢原子和 R4 为低级烷基时，R3 和 R4 不在喹啉环的第 6 和 7 位或第 6 和 8 位。