4-methyl-4H-furo[3,2-b]indole-2-carboxylic acid | 80019-53-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-methyl-4H-furo[3,2-b]indole-2-carboxylic acid
• 英文别名: 4-methyl-furo[3,2-b]indole-2-carboxylic acid；4-methylfuro[3,2-b]indole-2-carboxylic acid
• CAS: 80019-53-0
• 化学式: C₁₂H₉NO₃
• 分子量: 215.208
• InChiKey: IRRHKPBXHLNKLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-methyl-4H-furo[3,2-b]indole-2-carboxylic acid 在 氯化亚砜 作用下， 以 苯 为溶剂， 反应 0.5h， 以89%的产率得到4-methyl-furo[3,2-b]indole-2-carbonyl chloride
  参考文献：
  名称：

  Furo(3,2-b)indole derivatives. I. Synthesis and analgesic and anti-inflammatory activities of 4,6-disubstituted-furo(3,2-b)indole-2-carboxamide derivatives.

  摘要：

  合成了N-(3-哌啶丙基)-4, 6-二取代呋喃[3, 2-b]吲哚-2-羧酰胺衍生物，并利用小鼠醋酸扭体法和大鼠卡拉胶水肿法对其镇痛和抗炎活性进行了研究。部分化合物在动物模型中显示出显著的镇痛和抗炎活性。

  DOI：

  10.1248/cpb.32.4271
• 作为产物：
  描述：

  Methyl-4H-furo<3,2-b>-indol-2-carboxylat 在 sodium hydride 、 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.41h， 生成 4-methyl-4H-furo[3,2-b]indole-2-carboxylic acid
  参考文献：
  名称：

  Synthesis and anticancer activity of 2,4-disubstituted furo[3,2-b]indole derivatives

  摘要：

  We synthesized and evaluated a series of 2,4-disubstituted furo[3,2-b]indole derivatives for anticancer activity and established the structure activity relationships (SARs) of these compounds. Among all tested compounds, we found (5-((2-(hydroxymethyl)-4H-furo[3,2-b]indol-4-yl)methyl)furan-2-yl) methanol (10a) to be the most promising agent. In screening against NCI-60 human tumor cell lines, 10a exhibited highly selective anticancer activity and significant inhibitory activity against A498 renal cancer cells. Our COMPARE analysis results suggest that the 10a fingerprint is similar to that of NSC-754549, which is an isostere of YC-1. We further confirmed the significant antitumor activity of compound 10a with tests in the A498 xenograft nude mice model. Therefore, compound 10a should be further developed as a new drug candidate for treating renal cancer. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.06.012

文献信息

• Furoindoles
  申请人：Taisho Pharmaceutical Co., Ltd.

  公开号：US04288596A1

  公开（公告）日：1981-09-08

  The novel furoindole compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or lower alkyl having 1-3 carbon atoms, and R.sup.2 is hydrogen, halogen, trifluoromethyl, methoxy or methyl, are useful as analgesic and anti-inflammatory agents.

  这段话的中文翻译如下： 公式为##STR1##的新型呋喃吲哚化合物，其中R.sup.1代表氢或1-3个碳原子的低级烷基，R.sup.2代表氢、卤素、三氟甲基、甲氧基或甲基，可用作镇痛和抗炎药物。
• NAKASHIMA, YOSHIMOTO;KAWASHIMA, YUTAKA;AMANUMA, FUSAO;SOTA, KAORU;TANAKA,+, CHEM. AND PHARM. BULL., 1984, 32, N 11, 4271-4280
  作者：NAKASHIMA, YOSHIMOTO、KAWASHIMA, YUTAKA、AMANUMA, FUSAO、SOTA, KAORU、TANAKA,+

  DOI：——

  日期：——
• US4288596A
  申请人：——

  公开号：US4288596A

  公开（公告）日：1981-09-08
• Furo(3,2-b)indole derivatives. I. Synthesis and analgesic and anti-inflammatory activities of 4,6-disubstituted-furo(3,2-b)indole-2-carboxamide derivatives.
  作者：YOSHIMOTO NAKASHIMA、YUTAKA KAWASHIMA、FUSAO AMANUMA、KAORU SOTA、AKIRA TANAKA、TSUTOMU KAMEYAMA

  DOI：10.1248/cpb.32.4271

  日期：——

  N-(3-Piperidinopropyl)-4, 6-disubstituted-furo [3, 2-b] indole-2-carboxamide derivatives were prepared and examined for analgesic and anti-inflammatory activities using the acetic acid writhing method in mice and the carrageenin edema method in rats. Some of the compounds were found to have potent and anti-inflammatory activities in the animal model.

  合成了N-(3-哌啶丙基)-4, 6-二取代呋喃[3, 2-b]吲哚-2-羧酰胺衍生物，并利用小鼠醋酸扭体法和大鼠卡拉胶水肿法对其镇痛和抗炎活性进行了研究。部分化合物在动物模型中显示出显著的镇痛和抗炎活性。
• Synthesis and anticancer activity of 2,4-disubstituted furo[3,2-b]indole derivatives
  作者：Shi-Hong Zhuang、Yi-Chien Lin、Li-Chen Chou、Mei-Hua Hsu、Hui-Yi Lin、Chi-Hung Huang、Jin-Cherng Lien、Sheng-Chu Kuo、Li-Jiau Huang

  DOI：10.1016/j.ejmech.2013.06.012

  日期：2013.8

  We synthesized and evaluated a series of 2,4-disubstituted furo[3,2-b]indole derivatives for anticancer activity and established the structure activity relationships (SARs) of these compounds. Among all tested compounds, we found (5-((2-(hydroxymethyl)-4H-furo[3,2-b]indol-4-yl)methyl)furan-2-yl) methanol (10a) to be the most promising agent. In screening against NCI-60 human tumor cell lines, 10a exhibited highly selective anticancer activity and significant inhibitory activity against A498 renal cancer cells. Our COMPARE analysis results suggest that the 10a fingerprint is similar to that of NSC-754549, which is an isostere of YC-1. We further confirmed the significant antitumor activity of compound 10a with tests in the A498 xenograft nude mice model. Therefore, compound 10a should be further developed as a new drug candidate for treating renal cancer. (C) 2013 Elsevier Masson SAS. All rights reserved.