trimethyl(2-((((3R,4R,5S,6S,7R)-4,5,6-tris(benzyloxy)-7-(((3R,4R,5S,6S,7R)-4,5,6-tris(benzyloxy)-7-(((3R,4R,5S,6S,7S)-4,5,6-tris(benzyloxy)-7-methoxyoxepan-3-yl)oxy)oxepan-3-yl)oxy)oxepan-3-yl)oxy)methoxy)ethyl)silane | 1117805-63-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trimethyl(2-((((3R,4R,5S,6S,7R)-4,5,6-tris(benzyloxy)-7-(((3R,4R,5S,6S,7R)-4,5,6-tris(benzyloxy)-7-(((3R,4R,5S,6S,7S)-4,5,6-tris(benzyloxy)-7-methoxyoxepan-3-yl)oxy)oxepan-3-yl)oxy)oxepan-3-yl)oxy)methoxy)ethyl)silane
• CAS: 1117805-63-6
• 化学式: C₈₈H₁₀₂O₁₇Si
• 分子量: 1459.85
• InChiKey: VWXYYZDGKCRMIJ-JJHWJILXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.44
• 重原子数：
  106.0
• 可旋转键数：
  38.0
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  156.91
• 氢给体数：
  0.0
• 氢受体数：
  17.0

反应信息

• 作为反应物：
  描述：

  trimethyl(2-((((3R,4R,5S,6S,7R)-4,5,6-tris(benzyloxy)-7-(((3R,4R,5S,6S,7R)-4,5,6-tris(benzyloxy)-7-(((3R,4R,5S,6S,7S)-4,5,6-tris(benzyloxy)-7-methoxyoxepan-3-yl)oxy)oxepan-3-yl)oxy)oxepan-3-yl)oxy)methoxy)ethyl)silane 在 四丁基氟化铵 作用下， 以 四氢呋喃 、 N,N-二甲基丙烯基脲 为溶剂， 反应 3.0h， 以74%的产率得到
  参考文献：
  名称：

  1,5-α-d-Mannoseptanosides, Ring-Size Isomers That Are Impervious to α-Mannosidase-Catalyzed Hydrolysis

  摘要：

  1,5-D-Mannoseptanosyl di- and trisaccharide ring-size isomers of the corresponding mannopyranosyl oligosaccharides have been prepared. Remarkably, these compounds show no inhibition of the alpha-mannosidase-catalyzed hydrolysis of p-nitrophenyl-alpha-D-mannopyranoside.

  DOI：

  10.1021/ol8028065
• 作为产物：
  描述：

  trimethyl(2-((((3R,4R,5S,6S,7R)-4,5,6-tris(benzyloxy)-7-(phenylthio)oxepan-3-yl)oxy)methoxy)ethyl)silane 、 (3R,4R,5S,6S,7R)-4,5,6-tris(benzyloxy)-7-(((3R,4R,5S,6S,7S)-4,5,6-tris(benzyloxy)-7-methoxyoxepan-3-yl)oxy)oxepan-3-ol 在 N-碘代丁二酰亚胺 、 silver trifluoromethanesulfonate 作用下， 以 二氯甲烷 为溶剂， 以75%的产率得到trimethyl(2-((((3R,4R,5S,6S,7R)-4,5,6-tris(benzyloxy)-7-(((3R,4R,5S,6S,7R)-4,5,6-tris(benzyloxy)-7-(((3R,4R,5S,6S,7S)-4,5,6-tris(benzyloxy)-7-methoxyoxepan-3-yl)oxy)oxepan-3-yl)oxy)oxepan-3-yl)oxy)methoxy)ethyl)silane
  参考文献：
  名称：

  1,5-α-d-Mannoseptanosides, Ring-Size Isomers That Are Impervious to α-Mannosidase-Catalyzed Hydrolysis

  摘要：

  1,5-D-Mannoseptanosyl di- and trisaccharide ring-size isomers of the corresponding mannopyranosyl oligosaccharides have been prepared. Remarkably, these compounds show no inhibition of the alpha-mannosidase-catalyzed hydrolysis of p-nitrophenyl-alpha-D-mannopyranoside.

  DOI：

  10.1021/ol8028065

文献信息

• [EN] COMPOUNDS, INTERMEDIATES, AND METHODS OF PREPARING THE SAME<br/>[FR] COMPOSÉS, INTERMÉDIAIRES ET LEURS PROCÉDÉS DE PRÉPARATION
  申请人：UNIV EMORY

  公开号：WO2010078396A3

  公开（公告）日：2010-10-28