2-chloromethyl-5-phenoxy-pyridinehydrochloride | 1255787-62-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-chloromethyl-5-phenoxy-pyridinehydrochloride
• 英文别名: 2-(Chloromethyl)-5-phenoxypyridine;hydrochloride
• CAS: 1255787-62-2
• 化学式: C₁₂H₁₀ClNO*ClH
• 分子量: 256.131
• InChiKey: RLCBTICZASMCEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.03
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  22.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2,6-dimethoxy-phenyl)-5,5-dimethyl-oxazolidin-4-one 、 2-chloromethyl-5-phenoxy-pyridinehydrochloride 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 0.5h， 生成 2-(2,6-dimethoxy-phenyl)-5,5-dimethyl-3-(5-phenoxy-pyridin-2-ylmethyl)-oxazolidin-4-one
  参考文献：
  名称：

  NOVEL OXAZOLIDINONE DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS

  摘要：

  公开号：

  EP2430004B1

文献信息

• NOVEL OXAZOLIDINONE DERIVIATIVES
  申请人：Aissaoui Hamed

  公开号：US20120101111A1

  公开（公告）日：2012-04-26

  The present invention relates to oxazolidinone derivatives of formula (I) wherein Y, R 3 and R 4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.

  本发明涉及式(I)的噁唑烷酮衍生物，其中Y、R3和R4如描述中所述，以及它们的制备方法，它们的药用盐，以及它们作为药物的用途，包括含有一个或多个式(I)化合物的药物组合物，特别是它们作为促进睡眠的药物受体拮抗剂的用途。
• US8329706B2
  申请人：——

  公开号：US8329706B2

  公开（公告）日：2012-12-11
• [EN] NOVEL OXAZOLIDINONE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS OXAZOLIDINONE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2010131192A2

  公开（公告）日：2010-11-18

  The present invention relates to oxazolidinone derivatives of formula (I) wherein Y, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.
• NOVEL OXAZOLIDINONE DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP2430004B1

  公开（公告）日：2013-07-17