Radical Chain Reduction via Carbon Dioxide Radical Anion (CO<sub>2</sub><sup>•–</sup>)
作者:Cecilia M. Hendy、Gavin C. Smith、Zihao Xu、Tianquan Lian、Nathan T. Jui
DOI:10.1021/jacs.1c04427
日期:2021.6.23
developed an effective method for reductive radical formation that utilizes the radicalanion of carbondioxide (CO2•–) as a powerful single electron reductant. Through a polarity matched hydrogen atom transfer (HAT) between an electrophilic radical and a formate salt, CO2•– formation occurs as a key element in a new radical chain reaction. Here, radical chain initiation can be performed through photochemical
ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME
申请人:WARNER-LAMBERT COMPANY
公开号:EP0932598A1
公开(公告)日:1999-08-04
SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME
申请人:WARNER-LAMBERT COMPANY
公开号:EP1082127A1
公开(公告)日:2001-03-14
EP1082127A4
申请人:——
公开号:EP1082127A4
公开(公告)日:2002-10-09
[EN] ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1 beta CONVERTING ENZYME<br/>[FR] INHIBITEURS A BASE D'ESTER D'ASPARTATE DE L'ENZYME DE CONVERSION DE L'INTERLEUKINE-1 beta
申请人:——
公开号:WO1998016502A1
公开(公告)日:1998-04-23
[EN] The present invention relates to compounds that are inhibitors of interleukin-1 beta converting enzyme that have formula (I). This invention also relates to a method of treatment of stroke, inflammatory diseases, reperfusion injury, Alzheimer's disease, and shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1 beta converting enzyme. [FR] La présente invention se rapporte à des composés qui agissent en tant qu'inhibiteurs de l'enzyme de conversion de l'interleukine-1 beta et qui répondent à la formule (I). L'invention concerne également une méthode de traitement de l'ictus, des maladies inflammatoires, de la lésion de perfusion répétée, de la maladie d'Alzheimer et de la shigellose, ainsi qu'une composition pharmaceutiquement acceptable qui comprend un composant fonctionnant comme un inhibiteur de l'enzyme de conversion de l'interleukine-1 beta .