3-(5-羟基-2-硝基苯基)丙-2-烯酸 | 142010-16-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 中文名称: 3-(5-羟基-2-硝基苯基)丙-2-烯酸
• 英文名称: 2-Nitro-5-hydroxycinnamic acid
• 英文别名: 2-nitro-5-hydroxy-trans-cinnamic acid；5-hydroxy-2-nitro-cinnamic acid；6-Nitro-3-hydroxy-trans-zimtsaeure；2-Nitro-5-hydroxy-trans-zimtsaeure；5-Hydroxy-2-nitro-zimtsaeure；6-Nitro-m-cumarsaeure；3-(5-Hydroxy-2-nitrophenyl)prop-2-enoic acid；(E)-3-(5-hydroxy-2-nitrophenyl)prop-2-enoic acid
• CAS: 142010-16-0
• 化学式: C₉H₇NO₅
• 分子量: 209.158
• InChiKey: SPWWWLCTUNXBRR-DAFODLJHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  乙醇 、 3-(5-羟基-2-硝基苯基)丙-2-烯酸 生成 6-硝基香豆素
  参考文献：
  名称：

  A simple technique of using novel thread-holding and knot-pushing forceps for extracorporeal knot-tying

  摘要：

  We designed some novel knot-pushing forceps for extracorporeal knot-tying and describe herein our simple technique of utilizing them. These forceps are modified only by a single l-mm hole between their jaws, which hold a thread and push the knot toward the ligating tissue. The application of this simple device was handled well by surgeons beginning to perform advanced endoscopic surgery. The simple modification explained in this report seems applicable to most of the forceps currently used.

  DOI：

  10.1007/s005950070132
• 作为产物：
  描述：

  6-硝基香豆素 在 sodium hydroxide 作用下， 生成 3-(5-羟基-2-硝基苯基)丙-2-烯酸
  参考文献：
  名称：

  Sen; Chakravarti, Journal of the Indian Chemical Society, 1930, vol. 7, p. 247,249

  摘要：

  DOI：

文献信息

• Nitration of Cinnamic Acids Using Cerium (IV) Ammonium Nitrate Immobilized on Silica
  作者：Anna Messere、Alessandra Gentili、Isidoro Garella、Fabio Temussi、Benedetto Di Blasio、Antonio Fiorentino

  DOI：10.1081/scc-200030569

  日期：2004.1.1

  Abstract Treatment of cinnamic acids with cerium (IV) ammonium nitrate supported on silica (CAN/SiO2) was used to synthesize nitro derivative and ipso substitution products. The position of the substituents defines the type and the yields of the products. This is the first example of an ipso substitution reaction by solid‐phase approach.

  摘要 用二氧化硅负载的硝酸铈 (IV) 铵 (CAN/SiO2) 处理肉桂酸以合成硝基衍生物和 ipso 取代产物。取代基的位置决定了产物的类型和产率。这是通过固相方法进行 ipso 取代反应的第一个例子。
• Phenol derivatives, processes for their preparation and pharmaceutical compositions containing them
  申请人：GLAXO GROUP LIMITED

  公开号：EP0028063A1

  公开（公告）日：1981-05-06

  Compounds are disclosed which are phenoxyalkoxyphenyl derivatives of general formula (I) wherein Y represents the group -A, -ZA or OZ1A where A represents a carboxylic acid group, a 5-1H-tetrazolyf ring or a N-5-1 H-tetrazolylcarboxamide group; Z represents a Ci-4 alkylene, C2-4 alkenylene or C2-4 alkynylene chain optionally substituted by one or more C1-3 alkyl groups and Z1 represents a C1-4 alkylene chain optionally substituted by one or more C1-3 alkyl groups; X represents a C1-10 carbon chain which may be saturated or unsaturated in the case of chains containing at least 4 carbon atoms, and may be substituted by a hydroxy group or by one or more C1-3 alkyl groups, which chain may be interrupted by a benzene ring which may be linked through its 1- and 2-, 1- and 3-, or 1- and 4-positions; R1 represents a hydrogen atom or a C1-6 alkyl group; R2 represents the group -COR6 where R6 represents a hydrogen atom, an aryl group or a C1-6 alkyl group which may be substituted by an aryl group; R3 represents a C1-6 alkyl group or a C3-6 alkenyl group; and R4 and R5 which may be the same or different, each represents a hydrogen atom, a halogen atom or a hydroxy, Ci-3 alkoxy, C1-6 alkyl, C3-C6 alkenyl, C1-3 alkanoyl, nitro or carboxylic acid group with the proviso that R4 and R5 cannot both be nitro, alkanoyl or carboxylic acid groups, and physologically acceptable salts thereof. The compounds are potent antagonists of the action of slow reacting substance of anaphylaxis and are thus indicated for use in the treatment of obstructive airways diseases such as asthma and hay fever and in skin afflictions.

  所公开的化合物是通式(I)的苯氧基烷氧基苯基衍生物 其中 Y 代表基团-A、-ZA 或 OZ1A，其中 A 代表羧酸基团、5-1H-四氮唑环或 N-5-1 H-四氮唑甲酰胺基团； Z 代表任选被一个或多个 C1-3 烷基取代的 Ci-4亚烷基、C2-4 亚烯基或 C2-4 亚炔基链，Z1 代表任选被一个或多个 C1-3 烷基取代的 C1-4 亚烷基链； X 代表 C1-10 碳链，可以是饱和的 或不饱和（如果链中至少含有 4 个碳原子），并可被羟基取代 或一个或多个 C1-3 烷基基团取代，该链可 可被一个苯环打断，该苯环可通过以下方式连接 1-位和 2-位、1-位和 3-位或 1-位和 4-位相连； R1 代表氢原子或 C1-6 烷基； R2 代表基团-COR6，其中 R6 代表氢原子、芳基或可被芳基取代的 C1-6 烷基； R3 代表 C1-6 烷基或 C3-6 烯基；以及 R4和R5可以相同或不同，各自代表氢原子、卤素原子或羟基、Ci-3烷氧基、C1-6烷基、C3-C6烯基、C1-3烷酰基、硝基或羧酸基团，但R4和R5不能都是硝基、烷酰基或羧酸基团，以及它们的物理上可接受的盐。 这些化合物是过敏性休克慢反应物质的强效拮抗剂，因此可用于治疗阻塞性呼吸道疾病，如哮喘和花粉症，以及皮肤病。
• 2,6-Methano-1,3-benzodiazocines, a process for their preparation and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0335292A2

  公开（公告）日：1989-10-04

  The present invention relates to compounds of the formula I wherein R¹ is hydrogen, loweralkyl, loweralkylcarbonyl, loweralkylaminocarbonyl, cycloalkylaminocarbonyl, loweralkoxycarbonyl, aryloxycarbonyl, or arylaminocarbonyl; R² and R³ are independently hydrogen, loweralkyl, cycloalkylloweralkyl, arylloweralkyl, or loweralkenyl; R⁴ and R⁵ are independently hydrogen or loweralkyl; Y is halogen, loweralkyl, nitro, amino, loweralkylcarbonylamino, arylcarbonylamino, formyl or loweralkylaminocarbonyl; and n is an integer having a value of zero or 1; the geometrical isomers, optical antipodes or pharmaceutically acceptable acid addition salts thereof, and to a process for their preparation. The compound have analgesic acetivities, and can, there­fore, be used as medicaments.

  本发明涉及式 I 的化合物 其中R¹是氢、低级烷基、低级烷基羰基、低级烷基氨基羰基、环烷基氨基羰基、低级烷氧基羰基、芳氧基羰基或芳基氨基羰基；R²和R³独立地是氢、低级烷基、环烷基低级烷基、芳基低级烷基或低级烯基；R⁴和R⁵独立地是氢或低级烷基；Y 是卤素、低级烷基、硝基、氨基、低级烷基羰基氨基、芳基羰基氨基、甲酰基或低级烷基氨基羰基；n 是数值为 0 或 1 的整数；其几何异构体、光学对映异构体或药学上可接受的酸加成盐，以及其制备方法。 这些化合物具有镇痛乙酰活性，因此可用作药物。
• Sen; Chakravarti, Journal of the Indian Chemical Society, 1930, vol. 7, p. 247,249
  作者：Sen、Chakravarti

  DOI：——

  日期：——
• 28. Nitration of m-methoxycinnamic acid
  作者：S. N. Chakravarti、K. Ganapati、S. Aravamudhachari

  DOI：10.1039/jr9380000171

  日期：——