N-[3,5-bis(trifluoromethyl)phenyl]methanesulfonamide | 300561-26-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[3,5-bis(trifluoromethyl)phenyl]methanesulfonamide
• CAS: 300561-26-6
• 化学式: C₉H₇F₆NO₂S
• 分子量: 307.216
• InChiKey: QMZLVQXKUCOKFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  N-[3,5-bis(trifluoromethyl)phenyl]methanesulfonamide 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 丙酮 、 mineral oil 为溶剂， 反应 6.33h， 生成 dithiocarbonic acid S-{2-[methanesulfonyl(3,5-bis(trifluoromethyl)phenyl)amino]-2-oxo-ethyl} ester O-ethyl ester
  参考文献：
  名称：

  芳烃上的脱磺酰基自由基环封闭。苯并ze庚因-2-酮和5-芳基哌啶-2-酮的模块化途径

  摘要：

  N-黄嘌呤乙酰基-N-甲磺酰苯胺的分子间自由基加成到Boc保护的烯丙基胺上的加合物经历闭环反应，失去甲磺酰基，得到苯并ze庚因-2-酮。脱保护并暴露于三乙胺后，这些化合物重排为5-芳基-2-哌啶酮。该方法也代表了在氮杂环庚酮环的氮原子上未被取代的苯并ze庚因-2-酮的有用途径。

  DOI：

  10.1021/ol3005276
• 作为产物：
  描述：

  间二(三氟甲基)苯胺 在 吡啶 、 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 7.0h， 生成 N-[3,5-bis(trifluoromethyl)phenyl]methanesulfonamide
  参考文献：
  名称：

  Studies on Development of Sufficiently Chemoselective N-Acylation Reagents: N-Acyl-N-(2,3,4,5,6-pentafluorophenyl)methanesulfonamides

  摘要：

  A variety of storable N-acyl-N-(2,3,4,5,6-pentafluorophenyl)met (4a-e) prepared from N-2,3,4,5,6-pentafluorophenylmethanesulfonamide (3), have been developed after systematic research on the structure-reactivity relationship and were found to serve as N-acylation reagents exhibiting sufficiently good chemoselectivity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00549-4

文献信息

• DISPERSION OF WATER-INSOLUBLE COLORANT, METHOD OF PRODUCING SUBSTANCE CONTAINING WATER-INSOLUBLE COLORANT, FINE PARTICLES OF WATER-INSOLUBLE COLORANT, DISPERSING AGENT FOR WATER-INSOLUBLE COLORANT, AND RECORDING LIQUID, INK SET, PRINTED ARTICLE, METHOD OF FORMING IMAGE AND IMAGE FORMING APPARATUS USING THE SAME
  申请人：SANO Satoshi

  公开号：US20090246481A1

  公开（公告）日：2009-10-01

  A dispersion of a water-insoluble colorant containing: a medium containing water; fine particles of the water-insoluble colorant; and a polymer compound or a surfactant that includes at least one kind of electron-withdrawing group or group of atoms represented by any one of formulae (I) to (IV) as its hydrophilic part: wherein at least one of X 1 and X 2 represents an electron-withdrawing linking group on the condition that when at least one of X 1 and X 2 is not the linking group, the at least one of X 1 and X 2 represents an electron-withdrawing substituent; R 1 represents a hydrogen atom or a substituent; and M represents a hydrogen atom or a metal atom.

  一种水不溶性着色剂的分散体，包括：含水介质；水不溶性着色剂的细小颗粒；以及聚合物化合物或表面活性剂，其包含至少一种电子吸引基团或由式（I）至（IV）中的任何一种原子团表示的原子团作为其亲水部分：其中X1和X2中至少一个表示电子吸引连接基团，条件是当X1和X2中至少一个不是连接基团时，X1和X2中的至少一个表示电子吸引取代基；R1表示氢原子或取代基；M表示氢原子或金属原子。
• Dispersion of water-insoluble colorant, method of producing substance containing water-insoluble colorant, fine particles of water-insoluble colorant, dispersing agent for water-insoluble colorant, and recording liquid, ink set, printed article, method of forming image and image forming apparatus using the same
  申请人：Fujifilm Corporation

  公开号：EP2110416A2

  公开（公告）日：2009-10-21

  A dispersion of a water-insoluble colorant containing: a medium containing water; fine particles of the water-insoluble colorant; and a polymer compound or a surfactant that includes at least one kind of electron-withdrawing group or group of atoms represented by any one of formulae (I) to (IV) as its hydrophilic part: wherein at least one of X1 and X2 represents an electron-withdrawing linking group on the condition that when at least one of X1 and X2 is not the linking group, the at least one of X1 and X2 represents an electron-withdrawing substituent; R1 represents a hydrogen atom or a substituent; and M represents a hydrogen atom or a metal atom.

  一种水不溶性着色剂的分散液，其中包含：含水介质；水不溶性着色剂的细颗粒；以及聚合物化合物或表面活性剂，其亲水部分包括至少一种由式（I）至（IV）中任一项所代表的抽电子基团或原子团： 其中 X1 和 X2 中至少有一个代表抽电子连接基团，条件是当 X1 和 X2 中至少有一个不是连接基团时，X1 和 X2 中至少有一个代表抽电子取代基；R1 代表氢原子或取代基；M 代表氢原子或金属原子。
• US9274419B2
  申请人：——

  公开号：US9274419B2

  公开（公告）日：2016-03-01
• Desulfonylative Radical Ring Closure onto Aromatics. A Modular Route to Benzazepin-2-ones and 5-Arylpiperidin-2-ones
  作者：Nicolas Charrier、Zhibo Liu、Samir Z. Zard

  DOI：10.1021/ol3005276

  日期：2012.4.20

  ulfanilides to Boc-protected allylamine undergo ring closure with loss of a methanesulfonyl radical to give benzazepin-2-ones. Upon deprotection and exposure to triethylamine, these compounds rearrange into 5-aryl-2-piperidones. This approach also represents a useful route to benzazepin-2-ones unsubstituted on the nitrogen atom of the azepinone ring.

  N-黄嘌呤乙酰基-N-甲磺酰苯胺的分子间自由基加成到Boc保护的烯丙基胺上的加合物经历闭环反应，失去甲磺酰基，得到苯并ze庚因-2-酮。脱保护并暴露于三乙胺后，这些化合物重排为5-芳基-2-哌啶酮。该方法也代表了在氮杂环庚酮环的氮原子上未被取代的苯并ze庚因-2-酮的有用途径。
• Studies on Development of Sufficiently Chemoselective N-Acylation Reagents: N-Acyl-N-(2,3,4,5,6-pentafluorophenyl)methanesulfonamides
  作者：Kazuhiro Kondo、Erika Sekimoto、Junko Nakao、Yasuoki Murakami

  DOI：10.1016/s0040-4020(00)00549-4

  日期：2000.8

  A variety of storable N-acyl-N-(2,3,4,5,6-pentafluorophenyl)met (4a-e) prepared from N-2,3,4,5,6-pentafluorophenylmethanesulfonamide (3), have been developed after systematic research on the structure-reactivity relationship and were found to serve as N-acylation reagents exhibiting sufficiently good chemoselectivity. (C) 2000 Elsevier Science Ltd. All rights reserved.