4-(3-Oxo-1,3-diphenyl-propyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione | 909078-65-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 4-(3-Oxo-1,3-diphenyl-propyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione
• 英文别名: 4-(3-Oxo-1,3-diphenylpropyl)-3,4-dihydro-1H-1-benzazepine-2,5-dione
• CAS: 909078-65-5
• 化学式: C₂₅H₂₁NO₃
• 分子量: 383.447
• InChiKey: VWBKGSBRCKPOCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  63.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(3-Oxo-1,3-diphenyl-propyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione 在 tetraphosphorus decasulfide 、 NH₄Fe(SO)4*12H₂O 、 ammonium acetate 、 sodium hydride 、 碳酸氢钠 、 溶剂黄146 作用下， 以 xylene 为溶剂， 反应 48.26h， 生成 6-benzylamino-2,4-diphenyl-5H-pyrido<3,2-d><1>benzazepine
  参考文献：
  名称：

  吡啶并[3,4- d ]苯并ze庚因的合成†

  摘要：

  报道了新型杂环系统吡啶并[3,4- d ] [1]苯并ze庚因的一些衍生物的合成。因此，吡啶并[3,4 d ] [1]苯并吖庚因-7-酮6用所述迈克尔的环化来制备加合物5硫酸铁铵。6与五硫化二磷反应生成硫内酰胺7，甲基化后与胺反应生成reaction 10。

  DOI：

  10.1002/jhet.5570320319
• 作为产物：
  描述：

  1H-[1]-苯并氮杂卓-2,5(3H,4H)-二酮 、 反式-查耳酮 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以78%的产率得到4-(3-Oxo-1,3-diphenyl-propyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione
  参考文献：
  名称：

  吡啶并[3,4- d ]苯并ze庚因的合成†

  摘要：

  报道了新型杂环系统吡啶并[3,4- d ] [1]苯并ze庚因的一些衍生物的合成。因此，吡啶并[3,4 d ] [1]苯并吖庚因-7-酮6用所述迈克尔的环化来制备加合物5硫酸铁铵。6与五硫化二磷反应生成硫内酰胺7，甲基化后与胺反应生成reaction 10。

  DOI：

  10.1002/jhet.5570320319

文献信息

• <i>d</i>-Fused [1]Benzazepines with Selective in Vitro Antitumor Activity:  Synthesis and Structure−Activity Relationships
  作者：Andreas Link、Conrad Kunick

  DOI：10.1021/jm970675l

  日期：1998.4.1

  The synthesis of novel quinolino[3,2-d][1]benzazepines and pyrido[3,2-d][1]benzazepines is described. The in vitro antitumor activity of the compounds has been tested in the antitumor screening of the National Cancer Institute (NCI). Several 2,4-diarylpyrido[3,2-d][1]benzazepin-6-ones and -thiones turned out to exhibit considerable cytotoxicity for tumor cells. For studies of SAR within these series, substituents were introduced into the aromatic rings of the parent systems. Compounds from the thiolactam series tended to show higher potency than the corresponding lactams. Prominent compounds with noteworthy activity and remarkable selectivity for renal cancer cell lines are the lactams 10c, 10g, and 10h and the corresponding thiolactams 11c, 11g, and 11h. Methylation of the azepine nitrogen leads to complete loss of activity, whereas annelation of a triazolo ring at the lactam site or transformation of the thiolactam function to a thiolactim ether results in decreased antitumor activity and selectivity. Consequently, the secondary lactam or thiolactam structure of the seven-membered ring has to be regarded as essential for selective antitumor activity.
• Synthesis of pyrido[3,4-<i>d</i>] benzazepines
  作者：Conrad Kunick、Andreas Link

  DOI：10.1002/jhet.5570320319

  日期：1995.5

  The synthesis of some derivatives of the novel heterocyclic ring system pyrido[3,4-d][1]benzazepine is reported. Thus, pyrido[3,4-d][1]benzazepin-7-one 6 was prepared by cyclisation of the Michael adduct 5 with ammonium ferric sulfate. Reaction of 6 with phosphorus pentasulfide gave the thiolactam 7, which after methylation and subsequent reaction with amines furnished the amidines 10.

  报道了新型杂环系统吡啶并[3,4- d ] [1]苯并ze庚因的一些衍生物的合成。因此，吡啶并[3,4 d ] [1]苯并吖庚因-7-酮6用所述迈克尔的环化来制备加合物5硫酸铁铵。6与五硫化二磷反应生成硫内酰胺7，甲基化后与胺反应生成reaction 10。