benzyl 2,4-diphenylbut-3-ynylcarbamate | 1180001-40-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: benzyl 2,4-diphenylbut-3-ynylcarbamate
• 英文别名: benzyl N-(2,4-diphenylbut-3-ynyl)carbamate
• CAS: 1180001-40-4
• 化学式: C₂₄H₂₁NO₂
• 分子量: 355.436
• InChiKey: JHYRIKGSSDGQDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Benzyl 2-phenylaziridine-1-carboxylate 、 (phenylethynyl)dimethylaluminum 以 hexanes 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 benzyl 2-phenylpropylcarbamate 、 benzyl 2,4-diphenylbut-3-ynylcarbamate
  参考文献：
  名称：

  A practical regioselective ring-opening of activated aziridines with organoalanes

  摘要：

  The regioselective ring-opening of N-protected 2-phenylaziridines is accomplished by the addition of organoalanes in dichloromethane. With this simple method it is possible to introduce alkyl, alkenyl and alkynyl substituents at the benzylic position of the phenylaziridine to give the corresponding beta-phenyl-beta-substituted amines, as useful precursors for intramolecular hydroaminations, in high yields. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.05.081

文献信息

• A practical regioselective ring-opening of activated aziridines with organoalanes
  作者：Ferruccio Bertolini、Simon Woodward、Stefano Crotti、Mauro Pineschi

  DOI：10.1016/j.tetlet.2009.05.081

  日期：2009.8

  The regioselective ring-opening of N-protected 2-phenylaziridines is accomplished by the addition of organoalanes in dichloromethane. With this simple method it is possible to introduce alkyl, alkenyl and alkynyl substituents at the benzylic position of the phenylaziridine to give the corresponding beta-phenyl-beta-substituted amines, as useful precursors for intramolecular hydroaminations, in high yields. (C) 2009 Elsevier Ltd. All rights reserved.